Basophil Activation Test: Old and New Applications in Allergy
| العنوان: | Basophil Activation Test: Old and New Applications in Allergy |
|---|---|
| المؤلفون: | Alexandra F. Santos, Oliver Hemmings, Richard T McKendry, Matthew Kwok |
| المصدر: | Current Allergy and Asthma Reports |
| بيانات النشر: | Springer US, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, Allergy, IgG, medicine.medical_treatment, Immunology, Basophil activation test, Basophil, Basophil degranulation, medicine.disease_cause, Immunoglobulin E, 03 medical and health sciences, 0302 clinical medicine, Immune system, Allergen, Diagnosis, medicine, Immunology and Allergy, biology, business.industry, Immunologic/Diagnostic Tests in Allergy (P Matricardi, Section Editor), Immunotherapy, medicine.disease, Basophil activation, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, biology.protein, IgE, business |
| الوصف: | Purpose of Review The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT. Recent Findings Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. The BAT can also be used for research purposes to explore the mechanisms of allergy and tolerance at the level of the basophil, for instance by manipulating IgE and IgG and their receptors and by studying intracellular signalling cascade in response to allergen. Summary This review covers the applications of the BAT to the clinical management of allergic patients and the increased understanding of the mechanisms of immune response to allergens as well as technological advancements made in recent years. |
| اللغة: | English |
| تدمد: | 1534-6315 1529-7322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162d1afb01b1a1ff582b9852cdfbf8d0Test http://europepmc.org/articles/PMC6244909Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....162d1afb01b1a1ff582b9852cdfbf8d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15346315 15297322 |
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