Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study
| العنوان: | Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study |
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| المؤلفون: | Heikki Joensuu, Maija Saxelin, M. Kouri, Tarja Ruotsalainen, A Ollus, Inkeri Elomaa, Pia Österlund, Päivi Valta, Riitta Korpela |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Diarrhea, Male, Lactobacillus rhamnosus GG, Cancer Research, Lactobacillus GG, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Leucovorin, colorectal cancer, Adenocarcinoma, chemotherapy, Galactans, Gastroenterology, Antimetabolite, Mannans, 03 medical and health sciences, 0302 clinical medicine, Bolus (medicine), Internal medicine, Clinical Studies, Antineoplastic Combined Chemotherapy Protocols, Plant Gums, Adjuvant therapy, Humans, Medicine, 5-fluorouracil, Adverse effect, Aged, Neoplasm Staging, 030304 developmental biology, 0303 health sciences, Chemotherapy, Lacticaseibacillus rhamnosus, business.industry, Probiotics, Middle Aged, 3. Good health, Surgery, Regimen, Oncology, Tolerability, 030220 oncology & carcinogenesis, Female, Fluorouracil, Colorectal Neoplasms, business, probiotic |
| الوصف: | 5-Fluorouracil (5-FU)-based chemotherapy is frequently associated with diarrhoea. We compared two 5-FU-based regimens and the effect of Lactobacillus and fibre supplementation on treatment tolerability. Patients diagnosed with colorectal cancer (n=150) were randomly allocated to receive monthly 5-FU and leucovorin bolus injections (the Mayo regimen) or a bimonthly 5-FU bolus plus continuous infusion (the simplified de Gramont regimen) for 24 weeks as postoperative adjuvant therapy. On the basis of random allocation, the study participants did or did not receive Lactobacillus rhamnosus GG supplementation (1-2 x 10(10) per day) and fibre (11 g guar gum per day) during chemotherapy. Patients who received Lactobacillus had less grade 3 or 4 diarrhoea (22 vs 37%, P=0.027), reported less abdominal discomfort, needed less hospital care and had fewer chemotherapy dose reductions due to bowel toxicity. No Lactobacillus-related toxicity was detected. Guar gum supplementation had no influence on chemotherapy tolerability. The simplified de Gramont regimen was associated with fewer grade 3 or 4 adverse effects than the Mayo regimen (45 vs 89%), and with less diarrhoea. We conclude that Lactobacillus GG supplementation is well tolerated and may reduce the frequency of severe diarrhoea and abdominal discomfort related to 5-FU-based chemotherapy. |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328db10b74efdfc07ce3cba0be341240Test https://doi.org/10.1038/sj.bjc.6603990Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....328db10b74efdfc07ce3cba0be341240 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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