نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

1

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

المؤلفون: Rikke V. Grønlund, Harith Rajagopalan, Anastasia Tsakmaki, Jason A. West, David G. Parkes, David Maggs, Philip J. Pedersen, Soumitra S. Ghosh, Gavin A. Bewick

المصدر: PLoS ONE, Vol 16, Iss 3, p e0249239 (2021)
PLoS ONE

مصطلحات موضوعية: Blood Glucose, Male, Physiology, medicine.medical_treatment, Adipose tissue, Biochemistry, Impaired glucose tolerance, Mice, Endocrinology, Glucose Metabolism, Glucagon-Like Peptide 1, Insulin Secretion, Medicine and Health Sciences, Insulin, Glucose Tolerance, Multidisciplinary, Organic Compounds, Fatty Acids, Monosaccharides, Animal Models, Blood Sugar, Body Fluids, Chemistry, Blood, Physiological Parameters, Experimental Organism Systems, Adipose Tissue, Connective Tissue, Physical Sciences, Carbohydrate Metabolism, Medicine, Anatomy, medicine.drug, Research Article, Agonist, medicine.medical_specialty, medicine.drug_class, Science, Carbohydrates, Blood sugar, Mouse Models, Gastric Inhibitory Polypeptide, Carbohydrate metabolism, Diet, High-Fat, Research and Analysis Methods, Glucagon-Like Peptide-1 Receptor, Model Organisms, Internal medicine, medicine, Animals, Amino Acid Sequence, Triglycerides, Diabetic Endocrinology, Liraglutide, business.industry, Body Weight, Organic Chemistry, Antagonist, Chemical Compounds, Biology and Life Sciences, Glucose Tolerance Test, medicine.disease, Hormones, Mice, Inbred C57BL, Glucose, Biological Tissue, Metabolism, ROC Curve, Animal Studies, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af803cc4b7567abdbc98fa4b3b99c5dTest
https://doaj.org/article/0d79c9bba3884a64acb17d2b7e8c1e7bTest

2

Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK-A web service for small-molecule docking

المؤلفون: Pawel Pasznik, Szymon Niewieczerzal, Ewelina Rutkowska, Judyta Cielecka-Piontek, Dorota Latek

المصدر: PLoS ONE, Vol 14, Iss 1, p e0210705 (2019)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, 030204 cardiovascular system & hematology, Pharmacology, Molecular Dynamics, Biochemistry, 0302 clinical medicine, Endocrinology, Computational Chemistry, Medicine and Health Sciences, Receptors, Glucagon, Glucose homeostasis, Drug Interactions, Receptor, Multidisciplinary, Crystallography, Chemistry, Pharmaceutics, Physics, digestive, oral, and skin physiology, Condensed Matter Physics, Type 2 Diabetes, Polytherapy Drug Treatment, Hormone receptor, Physical Sciences, Crystal Structure, Medicine, Gastric inhibitory polypeptide receptor, Research Article, Signal Transduction, Transmembrane Receptors, Endocrine Disorders, Science, Adrenergic beta-Antagonists, Incretin, Molecular Dynamics Simulation, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Drug Therapy, Diabetes Mellitus, Solid State Physics, Humans, G protein-coupled receptor, Biology and Life Sciences, Proteins, Cell Biology, Hormones, 030104 developmental biology, Diabetes Mellitus, Type 2, Docking (molecular), Metabolic Disorders, G Protein Coupled Receptors, Glucagon receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc92176e922245c89eab5f919df625c8Test
https://doaj.org/article/9f66b019196849ba9fee258569c7ae1aTest

3

IA-Lab: A MATLAB framework for efficient microscopy image analysis development, applied to quantifying intracellular transport of internalized peptide-drug conjugate

المؤلفون: Adam Corrigan, Maria Karlsson, Maria Ölwegård-Halvarsson, Jan Wildenhain, Svenja Lünse, Johan Karlsson, Yinhai Wang, Laurent Knerr

المصدر: PLoS ONE, Vol 14, Iss 8, p e0220627 (2019)
PLoS ONE

مصطلحات موضوعية: Fluorescence-lifetime imaging microscopy, Computer science, Biochemistry, Intracellular Receptors, 0302 clinical medicine, Software, Software Design, Microscopy, Image Processing, Computer-Assisted, Medicine and Health Sciences, Molecular Targeted Therapy, MATLAB, computer.programming_language, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, Organic Compounds, Pharmaceutics, Transferrin, Software Engineering, Small molecule, Toolbox, Chemistry, 030220 oncology & carcinogenesis, Physical Sciences, Drug delivery, Engineering and Technology, Medicine, Software design, Algorithms, Research Article, Biotechnology, Signal Transduction, Computer and Information Sciences, Imaging Techniques, Science, Bioengineering, Image processing, Image Analysis, Research and Analysis Methods, Glucagon-Like Peptide-1 Receptor, Image (mathematics), Computer Software, 03 medical and health sciences, Fluorescence Imaging, Code (cryptography), Humans, 030304 developmental biology, Software Tools, business.industry, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Biological Transport, Cell Biology, Workflow, chemistry, Small Molecules, Peptides, Drug Delivery, Software engineering, business, computer, Intracellular transport

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c337c97e4bbe9071837be8696c583732Test
https://doi.org/10.1371/journal.pone.0220627Test

4

Exendin-4 Upregulates Adiponectin Level in Adipocytes via Sirt1/Foxo-1 Signaling Pathway

المؤلفون: Ping An, Wenhua Yan, Ting Li, Hua Zheng, Yiming Mu, Anping Wang, Bao-An Wang

المصدر: PLoS ONE, Vol 12, Iss 1, p e0169469 (2017)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Physiology, medicine.medical_treatment, Peptide Hormones, lcsh:Medicine, FOXO1, Biochemistry, Fats, Mice, 0302 clinical medicine, Endocrinology, Sirtuin 1, Animal Cells, Immune Physiology, Adipocytes, Medicine and Health Sciences, Insulin, Small interfering RNAs, Enzyme-Linked Immunoassays, Receptor, lcsh:Science, Connective Tissue Cells, Innate Immune System, Multidisciplinary, Chemistry, Forkhead Box Protein O1, digestive, oral, and skin physiology, Lipids, Up-Regulation, Nucleic acids, Adipose Tissue, Connective Tissue, Cytokines, Adiponectin, Signal transduction, Cellular Types, Anatomy, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Research Article, Agonist, medicine.medical_specialty, endocrine system, medicine.drug_class, Endocrine Disorders, Immunology, Research and Analysis Methods, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Insulin resistance, Downregulation and upregulation, Adipokines, Internal medicine, 3T3-L1 Cells, medicine, Genetics, Diabetes Mellitus, Animals, Non-coding RNA, Immunoassays, Nutrition, Diabetic Endocrinology, Venoms, lcsh:R, Biology and Life Sciences, Cell Biology, Molecular Development, medicine.disease, Hormones, Gene regulation, Diet, 030104 developmental biology, Biological Tissue, Immune System, Metabolic Disorders, Immunologic Techniques, Exenatide, RNA, lcsh:Q, Gene expression, Peptides, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4131f6af8b699303a110940323ca63a8Test
http://europepmc.org/articles/PMC5266308?pdf=renderTest

5

Drug-induced diabetes type 2: In silico study involving class B GPCRs

المؤلفون: Szymon Niewieczerzal, Ewelina Rutkowska, Dorota Latek, Judyta Cielecka-Piontek

المصدر: PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0208892 (2019)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, Protein Structure, Secondary, Endocrinology, 0302 clinical medicine, Medicine and Health Sciences, Receptors, Glucagon, Glucose homeostasis, Receptor, Crystallography, Multidisciplinary, Organic Compounds, Pharmaceutics, Physics, Monosaccharides, digestive, oral, and skin physiology, Drugs, Condensed Matter Physics, Chemistry, Hormone receptor, Physical Sciences, Crystal Structure, Medicine, Research Article, Signal Transduction, Transmembrane Receptors, Endocrine Disorders, Science, Carbohydrates, Incretin, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Adverse Reactions, Drug Therapy, Diabetes Mellitus, medicine, Solid State Physics, Animals, Humans, G protein-coupled receptor, business.industry, Insulin, Organic Chemistry, Statins, Chemical Compounds, Biology and Life Sciences, Proteins, Cell Biology, Hormones, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, Metabolic Disorders, G Protein Coupled Receptors, business, Glucagon receptor, Hormone

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72286c3ba73ccc7cd65f21f5ceb42f3Test
https://doi.org/10.1371/journal.pone.0208892Test

6

Proteomic analysis of INS-1 rat insulinoma cells: ER stress effects and the protective role of exenatide, a GLP-1 receptor agonist

المؤلفون: Kong-Joo Lee, Jin-Hwan Cho, Jae-Jin Lee, Moon-Ho Son, Mi Kyung Kim

المصدر: PLoS ONE, Vol 10, Iss 3, p e0120536 (2015)
PLoS ONE
PLOS ONE(10): 3

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d615464d4cd81c2f3e25f2ed6882caTest
http://europepmc.org/articles/PMC4368701?pdf=renderTest

7

Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids

المؤلفون: David G. Parkes, Chengzao Sun, Christopher J. Soares, Odile Esther Levy, Bruce Forood, James L. Trevaskis, Carrie Wittmer, Swati Gupta, Krystyna Tatarkiewicz, Michael R. Hanley, Carolyn M. Jodka, Diane Y. Lewis, Christine M. Mack, Soumitra S. Ghosh, Lawrence J. D'souza, Bronislava Gedulin

المصدر: PLoS ONE, Vol 8, Iss 10, p e78154 (2013)
PLoS ONE

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e705f92b184e49f551ea4bff50e90f1eTest
http://europepmc.org/articles/PMC3805588?pdf=renderTest

8

Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor

المؤلفون: Gary B. Willars, Jing Lu, Naichang Li

المصدر: PLoS ONE, Vol 7, Iss 10, p e47936 (2012)
PLoS ONE

مصطلحات موضوعية: Metabolite, Gene Expression, lcsh:Medicine, Signal transduction, Pharmacology, Mitogenic Signaling, chemistry.chemical_compound, Molecular cell biology, Signal Initiation, Glucagon-Like Peptide 1, Receptors, Glucagon, Insulin, Signaling in Cellular Processes, Membrane Receptor Signaling, Sulfones, Extracellular Signal-Regulated MAP Kinases, Receptor, lcsh:Science, Biotransformation, Second Messenger System, Multidisciplinary, Mechanisms of Signal Transduction, digestive, oral, and skin physiology, Signaling cascades, Signaling in Selected Disciplines, Hormone Receptor Signaling, Biochemistry, Calcium signaling cascade, Transmembrane Signaling, hormones, hormone substitutes, and hormone antagonists, Research Article, Agonist, endocrine system, MAPK signaling cascades, Allosteric modulator, medicine.drug_class, Adenylyl Cyclase Signaling Pathway, Allosteric regulation, Biology, Transfection, Signaling Pathways, Partial agonist, Glucagon-Like Peptide-1 Receptor, Cell Line, Allosteric Regulation, Quinoxalines, Calcium-Mediated Signal Transduction, medicine, Animals, Humans, Calcium Signaling, Adenylyl cyclase signaling cascade, Glucagon-like peptide 1 receptor, lcsh:R, Adenosine Monophosphate, Peptide Fragments, Rats, G-Protein Signaling, chemistry, Calcium, lcsh:Q, Peptides, Intestinal L Cells, Endocrinological Signaling

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5731c368ffb44887923ed9185c564fTest
http://europepmc.org/articles/PMC3477139?pdf=renderTest

9

GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice

المؤلفون: Karyn O'neil, Vedrana Stojanovic-Susulic, Janine J. Geerling, Kristen Picha, Patrick C.N. Rensen, Janny P. Schröder-van der Elst, Louis M. Havekes, Edwin T. Parlevliet, Tatiana Ort, Hanno Pijl, Johannes A. Romijn, Yanan Wang

المصدر: PLoS ONE, Vol 7, Iss 11, p e49152 (2012)
PLoS ONE, 11, 7
PLoS ONE, 7(11)
PLoS ONE

مصطلحات موضوعية: Apolipoprotein E, Blood Glucose, Male, Very low-density lipoprotein, Anatomy and Physiology, Apolipoprotein B, Mouse, Apolipoprotein E3, Gene Expression, Biomedical Innovation, Biochemistry, chemistry.chemical_compound, Mice, Endocrinology, Life, Glucagon-Like Peptide 1, Receptors, Glucagon, Insulin, Homeostasis, Multidisciplinary, biology, Liver Diseases, Fatty liver, Fatty Acids, Animal Models, Lipids, Liver, Lipogenesis, Medicine, lipids (amino acids, peptides, and proteins), EELS - Earth, Environmental and Life Sciences, MHR - Metabolic Health Research, Healthy Living, Research Article, medicine.medical_specialty, Lipoproteins, Animal Types, Science, Mice, Transgenic, Endocrine System, Gastroenterology and Hepatology, Glucagon-Like Peptide-1 Receptor, Glycerides, Molecular Genetics, Model Organisms, Internal medicine, medicine, Animals, Laboratory Animals, Obesity, Biology, Apolipoproteins B, Dyslipidemias, Nutrition, Diabetic Endocrinology, Triglyceride, Endocrine Physiology, Venoms, Proteins, Computational Biology, nutritional and metabolic diseases, Diabetes Mellitus Type 2, medicine.disease, Lipid Metabolism, Fatty Liver, Apolipoproteins, chemistry, Diabetes Mellitus, Type 2, biology.protein, Exenatide, Veterinary Science, Steatosis, Peptides, Physiological Processes, Lipoprotein

وصف الملف: application/x-www-form-urlencoded; charset=utf-8; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d388b05cc4253f1ecb4feb5ea8c1cd4dTest
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133675/pdf/?tool=EBITest

10

Glucagon-Like Peptide-1 Receptor Ligand Interactions: Structural Cross Talk between Ligands and the Extracellular Domain

المؤلفون: Graham M. West, Aaron D. Showalter, Bruce D. Pascal, Patrick R. Griffin, Kyle W. Sloop, Francis S. Willard

المصدر: PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e105683 (2014)

مصطلحات موضوعية: Proteomics, Agonist, endocrine system, medicine.drug_class, Molecular Sequence Data, Biophysics, lcsh:Medicine, Peptide, Crystallography, X-Ray, Ligands, Biochemistry, Protein Chemistry, Glucagon-Like Peptide-1 Receptor, Small Molecule Libraries, Protein structure, Receptors, Glucagon, Extracellular, medicine, Amino Acid Sequence, Biomacromolecule-Ligand Interactions, lcsh:Science, Receptor, G protein-coupled receptor, chemistry.chemical_classification, Multidisciplinary, Venoms, lcsh:R, digestive, oral, and skin physiology, Biology and Life Sciences, Deuterium Exchange Measurement, Ligand (biochemistry), Protein Structure, Tertiary, chemistry, Exenatide, lcsh:Q, Peptides, hormones, hormone substitutes, and hormone antagonists, Research Article, Binding domain

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edab5ee39620f7bf5e53aa63c233aa0Test
https://doi.org/10.1371/journal.pone.0105683Test

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