Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors
| العنوان: | Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors |
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| المؤلفون: | Martine Dubois, Florence Joly, Janette L. Vardy, M.B. de Ruiter, Gordon Winocur, Tim A. Ahles, Laure Tron, Marie Lange, Hélène Castel |
| المساهمون: | CASTEL, Hélène, Centre de recherche clinique [CHU Caen] (CRC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme Cancer et Cognition, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Ligue Nationale Contre le Cancer (LNCC)-Cancéropole Nord-Ouest, Service d'Oncologie médicale [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), University of New South Wales [Sydney] (UNSW), Memorial Sloane Kettering Cancer Center [New York], Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Rotman Research Institute at the Baycrest Centre (RRI), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Normandie Université (NU)-Normandie Université (NU)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Ann Oncol Annals of Oncology Annals of Oncology, 2019, 30 (2), pp.1925-1940. ⟨10.1093/annonc/mdz410⟩ Annals of Oncology, Elsevier, 2019, 30 (2), pp.1925-1940. ⟨10.1093/annonc/mdz410⟩ |
| بيانات النشر: | Oxford University Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Neurogenesis, Reviews, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antineoplastic Agents, Disease, Catechol O-Methyltransferase, [SCCO]Cognitive science, 03 medical and health sciences, 0302 clinical medicine, Apolipoproteins E, Cognition, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cancer Survivors, Internal medicine, Neoplasms, medicine, Humans, Cognitive Dysfunction, Cognitive rehabilitation therapy, Exercise, Polymorphism, Genetic, business.industry, Brain-Derived Neurotrophic Factor, Neuropsychology, Cancer, [SCCO] Cognitive science, Hematology, Executive functions, medicine.disease, Chemotherapy regimen, Cognitive training, 3. Good health, [SDV] Life Sciences [q-bio], 030104 developmental biology, 030220 oncology & carcinogenesis, Quality of Life, Cytokines, business |
| الوصف: | Background Advances in diagnostic and therapeutic strategies in oncology have significantly increased the chance of survival of cancer patients, even those with metastatic disease. However, cancer-related cognitive impairment (CRCI) is frequently reported in patients treated for non-central nervous system cancers, particularly during and after chemotherapy. Design This review provides an update of the state of the art based on PubMed searches between 2012 and March 2019 on ‘cognition’, ‘cancer’, ‘antineoplastic agents’ or ‘chemotherapy’. It includes the most recent clinical, imaging and pre-clinical data and reports management strategies of CRCI. Results Evidence obtained primarily from studies on breast cancer patients highlight memory, processing speed, attention and executive functions as the most cognitive domains impaired post-chemotherapy. Recent investigations established that other cancer treatments, such as hormone therapies and targeted therapies, can also induce cognitive deficits. Knowledge regarding predisposing factors, biological markers or brain functions associated with CRCI has improved. Factors such as age and genetic polymorphisms of apolipoprotein E, catechol-O-methyltransferase and BDNF may predispose individuals to a higher risk of cognitive impairment. Poor performance on neuropsychological tests were associated with volume reduction in grey matter, less connectivity and activation after chemotherapy. In animals, hippocampus-based memory and executive functions, mediated by the frontal lobes, were shown to be particularly susceptible to the effects of chemotherapy. It involves altered neurogenesis, mitochondrial dysfunction or brain cytokine response. An important next step is to identify strategies for managing cognitive difficulties, with primary studies to assess cognitive training and physical exercise regimens. Conclusions CRCI is not limited to chemotherapy. A multidisciplinary approach has improved our knowledge of the complex mechanisms involved. Nowadays, studies evaluating cognitive rehabilitation programmes are encouraged to help patients cope with cognitive difficulties and improve quality of life during and after cancer. |
| اللغة: | English |
| تدمد: | 0923-7534 1569-8041 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167f32eca9e66a3e121a2af89f8d53f0Test https://europepmc.org/articles/PMC8109411Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....167f32eca9e66a3e121a2af89f8d53f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237534 15698041 |
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