التفاصيل البيبلوغرافية
| العنوان: |
Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk |
| المؤلفون: |
Carina Conzelmann, Min Zou, Rüdiger Groß, Mirja Harms, Annika Röcker, Christian U. Riedel, Jan Münch, Janis A. Müller |
| المصدر: |
Viruses; Volume 11; Issue 7; Pages: 591 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
zika virus, breast milk, transmission, breastfeeding |
| جغرافية الموضوع: |
agris |
| الوصف: |
Zika virus (ZIKV) causes congenital neurologic birth defects, notably microcephaly, and has been associated with other serious complications in adults. The virus has been detected in human breast milk and possible transmissions via breastfeeding have been reported. Breast milk is rich in nutrients and bio-active substances that might directly affect viral infectivity. Thus, here, we analyzed the effect of human breast milk on ZIKV infection. We observed that fresh human breast milk had no effect on ZIKV, but found that upon storage, milk effectively suppressed infection. The antiviral activity is present in the fat-containing cream fraction of milk and results in the destruction of the structural integrity of viral particles, thereby abrogating infectivity. The release of the factor is time dependent but varies with donors and incubation temperatures. The viral titer of milk that was spiked with ZIKV decreased considerably upon storage at 37 °C for 8 h, was lost entirely after 2 days of 4 °C storage, but was not affected at −20 °C. This suggests that cold storage of milk inactivates ZIKV and that the antiviral factor in milk may also be generated upon breastfeeding and limit this transmission route of ZIKV. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Animal Viruses; https://dx.doi.org/10.3390/v11070591Test |
| DOI: |
10.3390/v11070591 |
| الإتاحة: |
https://doi.org/10.3390/v11070591Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.97C9C504 |
| قاعدة البيانات: |
BASE |
