المؤلفون: Zhiguang Zhou, Yu Liu, Gan Huang, Qing Liu, Jing Zou, Li Qian, Ying Zhou, Yuxiao Zhu, Tao Yang

المصدر: Diabetes & Metabolism Journal, Vol 44, Iss 2, Pp 260-266 (2020)
Diabetes & Metabolism Journal

مصطلحات موضوعية: Adult, Male, endocrine system, Adolescent, endocrine system diseases, autoantibodies, Endocrinology, Diabetes and Metabolism, Glutamate decarboxylase, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, c-peptide, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Islets of Langerhans, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Diabetes mellitus, medicine, Humans, latent autoimmune diabetes in adults, Technology/Devise, Type 1 diabetes, lcsh:RC648-665, biology, business.industry, C-peptide, Autoantibody, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Phenotype, Diabetes Mellitus, Type 2, chemistry, Case-Control Studies, Immunology, biology.protein, glutamate decarboxylase, Female, Original Article, Radiobinding assay, Antibody, business

الوصف: Background: The detection of glutamic acid decarboxylase 65 (GAD65) autoantibodies is essential for the prediction and diag nosis of latent autoimmune diabetes in adults (LADA). The aim of the current study was to compare a newly developed electro chemiluminescence (ECL)-GAD65 antibody assay with the established radiobinding assay, and to explore whether the new assay could be used to define LADA more precisely. Methods: Serum samples were harvested from 141 patients with LADA, 95 with type 1 diabetes mellitus, and 99 with type 2 dia betes mellitus, and tested for GAD65 autoantibodies using both the radiobinding assay and ECL assay. A glutamic acid decarbox ylase antibodies (GADA) competition assay was also performed to assess antibody affinity. Furthermore, the clinical features of these patients were compared. Results: Eighty-eight out of 141 serum samples (62.4%) from LADA patients were GAD65 antibody-positive by ECL assay. Com pared with ECL-GAD65 antibody-negative patients, ECL-GAD65 antibody-positive patients were leaner (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2d9264896b26a9cda74d22d4eb90f4Test
http://e-dmj.org/upload/pdf/dmj-44-260.pdfTest

المؤلفون: Sang-Man Jin, Kyungdo Han, Jae Hyeon Kim, You-Bin Lee, Bongsung Kim, Ji Eun Jun, Seung Eun Lee, Gyuri Kim, Jiyeon Ahn

المصدر: Diabetes & Metabolism Journal
Diabetes & Metabolism Journal, Vol 43, Iss 1, Pp 76-89 (2018)

مصطلحات موضوعية: Adult, Male, endocrine system diseases, Epidemiology, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Diabetes mellitus, Republic of Korea, medicine, Prevalence, Humans, In patient, education, Aged, Metabolic Syndrome, Type 1 diabetes, education.field_of_study, lcsh:RC648-665, Korea, business.industry, Incidence (epidemiology), Incidence, Preventive health, nutritional and metabolic diseases, Diabetes mellitus, type 1, Middle Aged, medicine.disease, National health insurance, Cardiovascular Diseases, Original Article, Female, Metabolic syndrome, business, human activities, Demography

الوصف: Background The prevalence and incidence of type 1 diabetes mellitus (T1DM) in all age groups and the prevalence of metabolic syndrome in patients with T1DM in Korea were estimated. Methods The incidence and prevalence of T1DM between 2007 and 2013 were calculated using the Korean National Health Insurance Service (NHIS) datasets of claims. Clinical characteristics and prevalence of metabolic syndrome in individuals with T1DM between 2009 and 2013 were determined using the database of NHIS preventive health checkups. Results The prevalence of T1DM in Korea between 2007 and 2013 was 0.041% to 0.047%. The annual incidence rate of T1DM in Korea in 2007 to 2013 was 2.73 to 5.02/100,000 people. Although the incidence rate of typical T1DM was highest in teenagers, it remained steady in adults over 30 years of age. In contrast, the incidence rate of atypical T1DM in 2013 was higher in people aged 40 years or older than in younger age groups. Age- and sex-adjusted prevalence of metabolic syndrome in patients with T1DM was 51.65% to 55.06% between 2009 and 2013. Conclusion T1DM may be more common in Korean adults than previously believed. Metabolic syndrome may be a frequent finding in individuals with T1DM in Korea.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff436ed53d194b399c78e250ec8c2376Test
http://europepmc.org/articles/PMC6387882Test

المؤلفون: Seul Gi Yoo, Kyoung Hwa Lee, Kyungdo Han, Yeonju La, Da Eun Kwon, Sang Hoon Han

المصدر: Diabetes & Metabolism Journal

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, endocrine system diseases, Epidemiology, Endocrinology, Diabetes and Metabolism, Population, Cytomegalovirus, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Diabetes mellitus, Republic of Korea, medicine, Humans, Disease, education, Aged, Dyslipidemias, education.field_of_study, Type 1 diabetes, business.industry, Incidence, Incidence (epidemiology), nutritional and metabolic diseases, Type 2 Diabetes Mellitus, Diabetes mellitus, type 2, Odds ratio, Middle Aged, medicine.disease, Case-Control Studies, Cytomegalovirus Infections, Hypertension, Cohort, Kidney Failure, Chronic, Original Article, Female, business, Follow-Up Studies, Cohort study

الوصف: Background: A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated im mune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evalu ated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM). Methods: From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 mil lion, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Diseases and Related-Health Problems 10th Revision (ICD-10) B25 code between 2010 and 2014 after exclusion of patients with T2DM to 2006. The 2,880 control patients without T2DM from 2006 to cohort entry point were selected between 2010 and 2014 by age, sex matching with case group. The subjects without new-onset T2DM were followed until 2015. T2DM, hypertension (HTN), dyslip idemia (DYS), and end-stage renal disease (ESRD) were coded as ICD-10. Results: The frequency of new-onset T2DM in case group was significantly higher than that in control (5.6% vs. 2.2%, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba51e48c27de7e2ef76822aec1cd03efTest
https://doi.org/10.4093/dmj.2018.0167Test