SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS
| العنوان: | SWIMMING EXERCISE STIMULATES NEURO-GENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS |
|---|---|
| المؤلفون: | Chae, C-H, Jung, S-L, An, S-H, Park, B-Y, Kim, T-W, Wang, S-W, Kim, J-H, Lee, H-C, Kim, H-T |
| المصدر: | Biology of Sport |
| بيانات النشر: | Institute of Sport in Warsaw, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | rats, physical training, nervous system, neurotrophic factors, olfactory bulb, brain, Original Article, progenitor cells |
| الوصف: | In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and 6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2’-deoxyuridine-5’-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6; p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB. |
| اللغة: | English |
| تدمد: | 2083-1862 0860-021X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::32504f6a49bb0ff30151cb9d143e3bb4Test http://europepmc.org/articles/PMC4296841Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........32504f6a49bb0ff30151cb9d143e3bb4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20831862 0860021X |
|---|