التفاصيل البيبلوغرافية
| العنوان: |
The Time Course of Pulmonary Function Tests in COPD Patients with Different Levels of Blood Eosinophils. |
| المؤلفون: |
Rogliani, Paola, Puxeddu, Ermanno, Ciaprini, Chiara, Ora, Josuel, Onorato, Angelo, Pezzuto, Gabriella, Calzetta, Luigino, Cazzola, Mario |
| المصدر: |
BioMed Research International; 10/16/2016, Vol. 2016, p1-7, 7p |
| مصطلحات موضوعية: |
CONFIDENCE intervals, EOSINOPHILS, OBSTRUCTIVE lung diseases, SCIENTIFIC observation, PROBABILITY theory, REGRESSION analysis, RESEARCH funding, RESPIRATORY measurements, PULMONARY function tests, SPIROMETRY, T-test (Statistics), TIME, VITAL capacity (Respiration), RETROSPECTIVE studies, DISEASE progression, DATA analysis software, DESCRIPTIVE statistics |
| مصطلحات جغرافية: |
ITALY |
| مستخلص: |
Only very few studies have investigated the influence of eosinophils on the functional progression of COPD. We aimed at retrospectively analyzing the trend of pulmonary function tests over time in patients with COPD according to two baseline blood eosinophil cell count strata (<2% [EOS−] and ≥2% [EOS+]). We used the last 9-year data present in the database of our outpatient clinic and selected only those who had two blood counts that would guarantee the stability of the value of eosinophils and serial spirometry for 4 consecutive years. The analysis of the time course of the spirometric variables analysed showed differences in FEV1 and FVC decline between the subjects of the EOS− group and those of the EOS+ group. The integrated evaluation of our results suggests that the different level of blood eosinophils in the two groups may have influenced independently the time course of the pulmonary function tests and identify two subgroups of subjects with specific disease characteristics: the hyperinflator and the rapid decliner, respectively. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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