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1دورية أكاديمية
المؤلفون: Benaglio, Paola, Zhu, Han, Okino, Mei Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret K.R., Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A., Sander, Maike, Gaulton, Kyle J.
المساهمون: Department of Pathology, Biosciences, Doctoral Programme in Integrative Life Science, Jussi Taipale / Principal Investigator
مصطلحات موضوعية: 3D chromatin interactions, accessible chromatin, beta cell, CRISPR screen, functional genomics, gene expression, high-throughput reporter assay, human genetics, proinflammatory cytokines, type 1 diabetes, General medicine, internal medicine and other clinical medicine, Biomedicine
وصف الملف: application/pdf
العلاقة: The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S., K.F., K.J.G., and B.R.; and DK105541 to M.S., K.F., and B.R. The work performed in this study was supported by NIH grants DK122607 and DK120429 to K.J.G. and M.S.; DK112155 to M.S. K.F. K.J.G. and B.R.; and DK105541 to M.S. K.F. and B.R. K.J.G. and M.S. conceived of and supervised the study. K.J.G. P.B. H.Z. M.O. and M.S. wrote the manuscript. J.T. and B.R. supervised the design and generation of SNP-SELEX data. K.F. supervised the design of SNP-SELEX and analyses of genomic data. S.P. supervised generation of single-cell data. P.B. performed statistical data analysis of genomic, CRISPR-KO screen, and genetic data; H.Z. performed the CRISPR-KO screen and interpreted the results; M.O. and M.M. performed genomic assays. J.Y. performed the SNP-SELEX assay. P.B. M.O. R.E. E.B. K.K. A.A. J.C. G.W. and J.N. performed bulk and single-cell data analysis. M.O. R.E. J.K. and S.C. performed functional validation experiments. P.B. N.N. Y.Q. A.A. and M.K.D. performed design and analysis of SNP-SELEX data. All authors contributed to and approved of the final version of the manuscript. K.J.G. is a consultant of Genentech and holds stock in Neurocrine Biosciences. B.R. is a consultant of Arima Genomics and a co-founder of Epigenome Technologies. P.B. is an employee of Shoreline Bioscience. N.N. is an employee of Guardant Health. E.B. is an employee and shareholder of Aetion. K.K. is an employee of Cartography Bio. Y.Q. is an employee of Sana Biotechnology. M.D. is an employee and shareholder of Seer. J.C. is an employee and shareholder of Pfizer.; Benaglio , P , Zhu , H , Okino , M L , Yan , J , Elgamal , R , Nariai , N , Beebe , E , Korgaonkar , K , Qiu , Y , Donovan , M K R , Chiou , J , Wang , G , Newsome , J , Kaur , J , Miller , M , Preissl , S , Corban , S , Aylward , A , Taipale , J , Ren , B , Frazer , K A , Sander , M & Gaulton , K J 2022 , ' Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines ' , Cell genomics , vol. 2 , no. 12 , 100214 . https://doi.org/10.1016/j.xgen.2022.100214Test; http://hdl.handle.net/10138/354977Test; c6a62712-0c8b-4078-9442-a6813e9052b5; 85143868567
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المصدر: Life Sciences. (23-24):950-955
مصطلحات موضوعية: Atropine, Male, Pain Threshold, Methiothepin, Receptors, Opioid, mu, Stimulation, Electric Stimulation Therapy, Pharmacology, Serotonergic, General Biochemistry, Genetics and Molecular Biology, Antinociception, Pharmacology, Toxicology and Pharmaceutics(all), Retrosplenial cortex, medicine, Animals, Pain Management, Chromatin structure remodeling (RSC) complex, Tail flick test, General Pharmacology, Toxicology and Pharmaceutics, Rats, Wistar, Receptor, Anterior pretectal nucleus, Cerebral Cortex, biology, Biochemistry, Genetics and Molecular Biology(all), Chemistry, Naloxone, General Medicine, Cobalt, Rats, Disease Models, Animal, Nociception, biology.protein, Incision pain, Neuroscience, Receptors, Serotonin, 5-HT1, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b6888784588517fdab3bbe21a7579eTest