دورية أكاديمية
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.
| العنوان: | The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. |
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| المؤلفون: | Gambarte Tudela, Julian Alberto, Capmany, Anahi, Romao, Maryse, Quintero, Cristian Andres, Miserey Lenkei, Stephanie, Raposo, Graça, Goud, Bruno, Damiani, Maria Elena |
| بيانات النشر: | Company of Biologists |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | CHLAMYDIA TRACHOMATIS, RAB PROTEINS, MULTIVESICULAR BODIES, PATHOGEN-HOST CELL INTERACTION, IPID TRANSPORT, https://purl.org/becyt/ford/1.6Test, https://purl.org/becyt/ford/1Test |
| الوصف: | Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport. These bacteria hijack Rab6-, Rab11- and Rab14-controlled trafficking pathways to acquire sphingomyelin from the Golgi apparatus. Another important source of sphingolipids, phospholipids and cholesterol are multivesicular bodies (MVBs). Despite their participation in chlamydial inclusion development and bacterial replication, the molecular mechanisms mediating MVBs-inclusion interaction remain unknown. In the present study, we demonstrate that Rab39a labels a subset of late endocytic vesicles -mainly MVBs- that move along microtubules. Moreover, Rab39a is actively recruited to chlamydial inclusions throughout the pathogen life cycle by a bacterial-driven process and depending on its GTP/GDP binding state. Interestingly, Rab39a participates in the delivery of MVB and host sphingolipids to maturing chlamydial inclusions thereby promoting inclusion growth and bacterial development. Altogether, our findings indicate that Rab39a favours chlamydial replication and infectivity. This is the first report showing a late endocytic Rab GTPase involved in chlamydial infection development. ; Fil: Gambarte Tudela, Julian Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina ; Fil: Capmany, Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina ; Fil: Romao, Maryse. Institute Curie; Francia ; Fil: Quintero, Cristian Andres. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0021-9533 1477-9137 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/http://jcs.biologists.org/content/128/16/3068Test; http://hdl.handle.net/11336/41303Test; Gambarte Tudela, Julian Alberto; Capmany, Anahi; Romao, Maryse; Quintero, Cristian Andres; Miserey Lenkei, Stephanie; et al.; The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.; Company of Biologists; Journal of Cell Science; 128; 16; 8-2015; 3068-3081; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1242/jcs.170092Test http://hdl.handle.net/11336/41303Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/arTest/ |
| رقم الانضمام: | edsbas.1D9FDC6A |
| قاعدة البيانات: | BASE |
| تدمد: | 00219533 14779137 |
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