Efficacy of interleukin-6 in combination with D-dimer in predicting early poor postoperative prognosis after acute stanford type a aortic dissection
| العنوان: | Efficacy of interleukin-6 in combination with D-dimer in predicting early poor postoperative prognosis after acute stanford type a aortic dissection |
|---|---|
| المؤلفون: | Xian-Biao Xie, Jia-Hui Li, Linfeng Xie, Liang-Wan Chen, Zhihuang Qiu, Qingsong Wu, Liang Liang Yan, Yue Shen |
| المصدر: | Journal of Cardiothoracic Surgery Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Acute Stanford a aortic dissection, 030204 cardiovascular system & hematology, Logistic regression, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Odds Ratio, 030212 general & internal medicine, Postoperative Period, Aortic dissection, Prognostic factor, Area under the curve, General Medicine, Middle Aged, Prognosis, Cardiothoracic surgery, Female, Cardiology and Cardiovascular Medicine, Research Article, Pulmonary and Respiratory Medicine, medicine.medical_specialty, China, lcsh:Surgery, Predictive value, Sensitivity and Specificity, lcsh:RD78.3-87.3, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, D-dimer, medicine, Humans, Retrospective Studies, Creatinine, Aortic Aneurysm, Thoracic, business.industry, Interleukin-6, Odds ratio, lcsh:RD1-811, medicine.disease, Confidence interval, Aortic Dissection, chemistry, ROC Curve, lcsh:Anesthesiology, Surgery, business, Biomarkers |
| الوصف: | Background We studied early poor postoperative prognosis in acute Stanford type A aortic dissection (ATAAD) patients and investigated the predictive effect of interleukin-6 (IL-6) combined with D-dimer in the early poor postoperative prognosis after ATAAD. Methods Data on 141 ATAAD patients, who underwent emergency surgery between January 2018 and December 2018 at our hospital, were studied. We analyzed early postoperative prognosis using two patient groups. Patients with good prognosis were included in group A and those with poor prognosis were in group B. Univariate logistic and multivariable logistic regression analysis were performed for poor early postoperative prognosis. Results Preoperative IL-6 level was lower (57.8 ± 39.0 vs 211.0 ± 153.7 pg/mL, p p 108 pg/mL (area under the curve: AUC = 0.901) and D-dimer > 14.0 μg/mL (AUC = 0.817). Univariate logistic regression analysis showed that IL-6 > 108 pg/mL, D-dimer > 14.0 μg/mL, prothrombin time > 15 s, creatinine > 135 mmol/mL, and operation time > 306 min for ATAAD appeared to be early postoperative risk factors of poor prognosis. Multivariable logistic regression analysis showed that IL-6 > 108 pg/mL and D-dimer > 14.0 μg/mL were early postoperative risk factors for poor prognosis after ATAAD, and the odds ratios (ORs) of IL-6 > 108 pg/mL and D-dimer > 14.0 μg/mL were 24.937 (6.837, 90.931) and 18.757 (5.094, 69.075), respectively. When IL-6 was > 108 pg/mL (AUC = 0.901), the sensitivity and specificity of predicting early postoperative prognosis after ATAAD were 79.4 and 89.7%, respectively (95% confidence interval [CI] 0.839 to 0.963). When D-dimer was > 14.0 g/mL (AUC = 0.817), the sensitivity and specificity were 82.4 and 84.1%, respectively (95% CI 0.731 to 0.903). When combined with D-dimer (AUC = 0.936) (95% CI 0.793 to 0.979), the AUC values were more predictive than those for the individual marker. Conclusion IL-6 > 108 pg/mL and D-dimer > 14.0 μg/mL is of high predictive value for the assessment of early poor postoperative prognosis after ATAAD. And IL-6 > 108 pg/mL in combination with D-dimer > 14.0 μg/mL is of higher predictive value. |
| اللغة: | English |
| تدمد: | 1749-8090 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d3fffd9def2063304a136e4e356802Test http://europepmc.org/articles/PMC7364558Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....66d3fffd9def2063304a136e4e356802 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17498090 |
|---|