Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations
| العنوان: | Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations |
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| المؤلفون: | Sofia D. Merajver, Carlos Murga-Zamalloa, Ernest Adjei, Jessica Bensenhave, Kathy A. Toy, Lisa A. Newman, Kofi K. Gyan, Joseph K. Oppong, Aisha Jibril, Melissa Davis, Baffour Awuah, Celina G. Kleer, Mark J. Hoenerhoff, Barbara Salem, Max S. Wicha, Evelyn Jiagge, George Divine |
| المصدر: | Journal of Global Oncology Journal of Global Oncology, Vol 4, Pp 1-8 (2018) |
| بيانات النشر: | American Society of Clinical Oncology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Adult, Cancer Research, medicine.medical_specialty, medicine.drug_class, Receptor, ErbB-2, Estrogen receptor, Black People, Breast Neoplasms, Triple Negative Breast Neoplasms, lcsh:RC254-282, Ghana, Aldehyde Dehydrogenase 1 Family, White People, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Progesterone receptor, Biomarkers, Tumor, Medicine, Original Report, Humans, Receptor, business.industry, Retinal Dehydrogenase, Middle Aged, medicine.disease, Androgen, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, United States, Androgen receptor, Black or African American, Gene Expression Regulation, Neoplastic, Isoenzymes, 030104 developmental biology, Receptors, Estrogen, Estrogen, Receptors, Androgen, 030220 oncology & carcinogenesis, Female, Ethiopia, business, Receptors, Progesterone |
| الوصف: | Purpose Population-based incidence rates of breast cancers that are negative for estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2/ neu (triple-negative breast cancer [TNBC]) are higher among African American (AA) compared with white American (WA) women, and TNBC prevalence is elevated among selected populations of African patients. The extent to which TNBC risk is related to East African versus West African ancestry, and whether these associations extend to expression of other biomarkers, is uncertain. Methods We used immunohistochemistry to evaluate estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2/ neu, androgen receptor and aldehyde dehydrogenase 1 (ALDH1) expression among WA (n = 153), AA (n = 76), Ethiopian (Eth)/East African (n = 90), and Ghanaian (Gh)/West African (n = 286) patients with breast cancer through an institutional review board–approved international research program. Results Mean age at diagnosis was 43, 49, 60, and 57 years for the Eth, Gh, AA, and WA patients, respectively. TNBC frequency was higher for AA and Gh patients (41% and 54%, respectively) compared with WA and Eth patients (23% and 15%, respectively; P < .001) Frequency of ALDH1 positivity was higher for AA and Gh patients (32% and 36%, respectively) compared with WA and Eth patients (23% and 17%, respectively; P = .007). Significant differences were observed for distribution of androgen receptor positivity: 71%, 55%, 42%, and 50% for the WA, AA, Gh, and Eth patients, respectively ( P = .008). Conclusion Extent of African ancestry seems to be associated with particular breast cancer phenotypes. West African ancestry correlates with increased risk of TNBC and breast cancers that are positive for ALDH1. |
| اللغة: | English |
| تدمد: | 2378-9506 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef99be324c501ceac7221d24a763c4f1Test http://europepmc.org/articles/PMC6818279Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ef99be324c501ceac7221d24a763c4f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23789506 |
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