مورد إلكتروني
Fetal rat hearts do not display acute cardiotoxicity in response to maternal Doxorubicin treatment.
| العنوان: | Fetal rat hearts do not display acute cardiotoxicity in response to maternal Doxorubicin treatment. |
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| المصدر: | The Journal of Pharmacology and Experimental Therapeutics, Vol. 346, no.3, p. 362-369 (2013) |
| بيانات النشر: | American Society for Pharmacology and Experimental Therapeutics 2013 |
| تفاصيل مُضافة: | UCL - (SLuc) Service d'obstétrique Mhallem Gziri, Mina Pokreisz, Peter De Vos, Rita Verbeken, Eric Debiève, Frédéric Mertens, Luc Janssens, Stefan P Amant, Frédéric |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Anthracyclines are used to treat cancers during the second and third trimester of pregnancy. The chemotherapeutic effect of anthracyclines is associated with a dose- and time-dependent cardiotoxicity that is well described for infants and adults. However, data regarding fetal anthracycline-related cardiotoxicity after administration of chemotherapeutics during pregnancy are limited. In this study, we analyzed the acute effect of doxorubicin, an anthracycline derivative, on fetal and maternal rat myocardium. We injected 10 or 20 mg/kg i.v. doxorubicin to pregnant Wistar rats at day 18 of pregnancy; age-matched pregnant rats injected with physiologic saline served as controls. Maternal echocardiography and fetal Doppler scanning were performed before the injection and before sacrifice. Cesarean operation was performed at day 19 or 20, and maternal and fetal blood samples and heart biopsies were collected to measure apoptosis, the impact on cell proliferation, and structural cardiac damage. Acute maternal cardiotoxicity is associated with loss of body weight, moderately deteriorated left ventricular function, induction of apoptosis, and a decrease in cell turnover. Despite a 30% lower fetal body weight and elevated plasma B-type natriuretic peptide concentrations after doxorubicin administration, the fetal hearts had intact microstructure, an unaltered number of apoptotic cells, and preserved cell proliferation compared with controls. Our study suggests that acute treatment using anthracyclines during pregnancy impairs maternal cardiac function, whereas fetal hearts are protected. |
| مصطلحات الفهرس: | Animals, Female, Fetal Heart, Heart Diseases, In Situ Nick-End Labeling, Injections, Intravenous, Maternal-Fetal Exchange, Myocardium, Myosins, Organ Size, Pregnancy, Antibiotics, Antineoplastic, RNA, Rats, Rats, Wistar, Transcription, Genetic, Apoptosis, Atrial Natriuretic Factor, Body Weight, Cell Proliferation, DNA Fragmentation, Doxorubicin, Echocardiography, info:eu-repo/semantics/article |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UCDLC oai:dial.uclouvain.be:boreal:163326 boreal:163326 info:doi/10.1124/jpet.113.205419 info:pmid/23792410 urn:ISSN:0022-3565 urn:EISSN:1521-0103 1130478165 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1130478165 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |