نتائج البحث

1

CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes

المؤلفون: Mark Harris, Ranjeny Thomas, Martin J. Hessner, Rhonda Geoffrey, Anne-Sophie Bergot, Breanna Lam, Kerry Buchanan, Elisavet Serti, Rosita Moya, Alessandra Mandelli, Irene Gotuzzo, Manuela Battaglia, Joanna D. Davies, Aditi Narsale, Benedetta Pessina, Gian Maria Giamporcaro, TingTing Lu

المصدر: JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Oncology, Autoimmune diseases, medicine.medical_treatment, Cell, Autoimmunity, medicine.disease_cause, 0302 clinical medicine, T-Lymphocyte Subsets, IL-2 receptor, Child, education.field_of_study, Diabetes, General Medicine, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, Disease Progression, Medicine, Female, Immunotherapy, Research Article, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Population, Immunology, T cells, Alefacept, Interleukin-7 Receptor alpha Subunit, Young Adult, 03 medical and health sciences, Diabetes mellitus, Internal medicine, medicine, Humans, education, Proportional Hazards Models, Type 1 diabetes, business.industry, Interleukin-2 Receptor alpha Subunit, Infant, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Multivariate Analysis, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ca9272dda4aa45bece327b8ae55f8Test
https://doaj.org/article/20ba8c4ce6b4454ea7c69dca229e3557Test

2

Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

المصدر: JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Cancer immunotherapy, Brain cancer, Mice, 0302 clinical medicine, 5'-Nucleotidase, Immune Checkpoint Inhibitors, Cells, Cultured, Brain Neoplasms, Apyrase, Glioma, General Medicine, Middle Aged, Isocitrate Dehydrogenase, Oncology, 030220 oncology & carcinogenesis, Medicine, Female, Immunosuppressive Agents, Research Article, medicine.drug, Adult, IDH1, Receptor, Adenosine A2A, Immunology, 03 medical and health sciences, Immune system, Downregulation and upregulation, Antigens, CD, Cell Line, Tumor, medicine, Animals, Humans, Aged, business.industry, Therapeutic effect, medicine.disease, Adenosine, Adenosine receptor, Mice, Inbred C57BL, 030104 developmental biology, Cancer research, Neoplasm Grading, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b7362d1d0c19278cd2192b48b6dbf5Test
https://doi.org/10.1172/jci.insight.134386Test

3

Regulation of glycolysis and the Warburg effect in wound healing

المؤلفون: Dalia Barayan, Abdikarim Abdullahi, Christopher Auger, Roohi Vinaik, Marc G. Jeschke

المصدر: JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, Inflammasomes, Mice, 0302 clinical medicine, Keloid, Glycolysis, skin and connective tissue diseases, Skin, Mice, Knockout, Glucose metabolism, Glucose Transporter Type 1, Anti-Inflammatory Agents, Non-Steroidal, Inflammasome, General Medicine, Middle Aged, Warburg effect, 3. Good health, 030220 oncology & carcinogenesis, Medicine, Female, Inflammation Mediators, medicine.symptom, Burns, Research Article, medicine.drug, Adult, Pyruvate Kinase, Inflammation, Therapeutics, 03 medical and health sciences, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Wound Healing, business.industry, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Anaerobic glycolysis, Case-Control Studies, Cancer research, Wound healing, business, Pyruvate kinase, Naphthoquinones

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df55c86a285b8b6069855b42530f20bbTest
https://doi.org/10.1172/jci.insight.138949Test

4

Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia

المساهمون: UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition

المصدر: JCI Insight, Vol. 5, no. 2, p. e134221 (2020)
JCI Insight
JCI insight

مصطلحات موضوعية: Male, 0301 basic medicine, Mitochondrion, Mice, Endocrinology, 0302 clinical medicine, Glucagon-Like Peptide 1, Cerebellum, Ganglia, Spinal, Insulin-Secreting Cells, Iron-Binding Proteins, Insulin, Glucose homeostasis, Gene Knock-In Techniques, Mice, Knockout, biology, Diabetes, Neurodegeneration, Brain, General Medicine, Middle Aged, Sciences bio-médicales et agricoles, Mitochondria, 3. Good health, 030220 oncology & carcinogenesis, Female, medicine.symptom, Research Article, medicine.drug, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Ataxia, Adolescent, Iron, Incretin, Neuroscience, Neuroprotection, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Aged, business.industry, medicine.disease, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Gene Expression Regulation, Friedreich Ataxia, Frataxin, biology.protein, Exenatide, Reactive Oxygen Species, Trinucleotide Repeat Expansion, business

وصف الملف: 2 full-text file(s): application/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b200b55a913111fdc37f52ecd11c1aTest
https://hdl.handle.net/2078Test.1/225377

5

IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation

المؤلفون: Deborah A. Meyers, Matthew S. Godwin, Annette T. Hastie, Chad Steele, Sadis Matalon, Jonathan P. Blackburn, Zhihong Yu, Jaleesa M. Garth, MaryJane Jones, Kristen M. Reeder

المصدر: JCI Insight. 4

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Allergy, Interleukin-1beta, Atopy, Mice, 03 medical and health sciences, 0302 clinical medicine, Interleukin-1alpha, Hypersensitivity, medicine, Animals, Humans, Asthma, Anakinra, medicine.diagnostic_test, business.industry, Fungi, Sputum, General Medicine, medicine.disease, respiratory tract diseases, Mice, Inbred C57BL, Interleukin 1 Receptor Antagonist Protein, 030104 developmental biology, Bronchoalveolar lavage, Bronchial hyperresponsiveness, 030220 oncology & carcinogenesis, Immunology, Female, Methacholine, Bronchial Hyperreactivity, medicine.symptom, business, Bronchoalveolar Lavage Fluid, Signal Transduction, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a375742536967c364aca7c4763e546f8Test
https://doi.org/10.1172/jci.insight.129055Test

6

Human adipose beiging in response to cold and mirabegron

المؤلفون: Brian S. Finlin, Hasiyet Memetimin, Caroline M. Alexander, Kelly A. Jones, Zachary R. Johnson, Amy L. Confides, Philip A. Kern, Esther E. Dupont-Versteegden, Patrick G. Sullivan, Beibei Zhu, Philip M. Westgate, Hemendra J. Vekaria, Brianna D. Harfmann, Ildiko Kasza

المصدر: JCI Insight. 3

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Biopsy, Subcutaneous Fat, Adipose tissue, Adrenergic beta-3 Receptor Agonists, White adipose tissue, Mitochondrion, 03 medical and health sciences, Internal medicine, Phenomenon, medicine, Humans, Obesity, Uncoupling Protein 1, business.industry, nutritional and metabolic diseases, Membrane Proteins, Thermogenesis, General Medicine, Adipose Tissue, Beige, Middle Aged, Lipid Metabolism, Beige Adipocytes, Thermogenin, Cold Temperature, Thiazoles, 030104 developmental biology, Endocrinology, Immunohistochemistry, lipids (amino acids, peptides, and proteins), Acetanilides, Female, Clinical Medicine, Energy Metabolism, Mirabegron, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81db1a72f964bbdbb3913524706d8099Test
https://doi.org/10.1172/jci.insight.121510Test

7

Follicular helper T cell signature in type 1 diabetes

المؤلفون: Partheepan Narendran, Kesley Attridge, Lucy S. K. Walker, Chun Jing Wang, Lukasz Wardzinski, Louise E. Clough, Sapna Patel, Frank Heuts, Rupert Kenefeck, Tauseef Kapadi, Miranda Rosenthal, Masahiro Ono, David M. Sansom, Alexandros Kogimtzis

المصدر: Journal of Clinical Investigation. 125:292-303

مصطلحات موضوعية: Adult, Male, Receptors, CXCR5, Interleukin 2, Cellular differentiation, T cell, Mice, Transgenic, Human leukocyte antigen, Biology, Lymphocyte Activation, Autoantigens, 03 medical and health sciences, Interleukin 21, 0302 clinical medicine, medicine, Animals, Humans, Cytotoxic T cell, IL-2 receptor, Pancreas, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, Interleukins, T-Lymphocytes, Helper-Inducer, General Medicine, Up-Regulation, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Case-Control Studies, T cell differentiation, Immunology, Interleukin-2, Female, Lymph Nodes, Transcriptome, Immunologic Memory, Research Article, 030215 immunology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd17746e98f6767d1745f32ff8ac3631Test
https://doi.org/10.1172/jci76238Test

8

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

المساهمون: University of Zurich

المصدر: The Journal of clinical investigation

مصطلحات موضوعية: Kidney Glomerulus, Gene Dosage, 030232 urology & nephrology, 2700 General Medicine, mTORC1, urologic and male genital diseases, mTORC2, 10052 Institute of Physiology, Podocyte, Diabetic nephropathy, Mice, 0302 clinical medicine, 10035 Clinic for Nephrology, Diabetic Nephropathies, Mice, Knockout, Mice, Inbred ICR, 0303 health sciences, Podocytes, TOR Serine-Threonine Kinases, General Medicine, Glomerular Hypertrophy, female genital diseases and pregnancy complications, 3. Good health, Proteinuria, medicine.anatomical_structure, Disease Progression, Research Article, medicine.drug, Adult, medicine.medical_specialty, 610 Medicine & health, Mice, Transgenic, Mechanistic Target of Rapamycin Complex 1, Biology, Diabetes Mellitus, Experimental, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Genetic Predisposition to Disease, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, 030304 developmental biology, Sirolimus, urogenital system, Nephrosis, Lipoid, Proteins, Glomerulosclerosis, Regulatory-Associated Protein of mTOR, medicine.disease, Mice, Inbred C57BL, Rapamycin-Insensitive Companion of mTOR Protein, Endocrinology, Multiprotein Complexes, Trans-Activators, Commentary, 570 Life sciences, biology, Carrier Proteins, Transcription Factors

وصف الملف: application/pdf; JCI-Gödel-2011.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a86224537edb7a43f7fa7111588b9aTest
https://doi.org/10.1172/jci44774Test

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