دورية أكاديمية
CRISPR-Cas9 Utility in Genome Engineering
| العنوان: | CRISPR-Cas9 Utility in Genome Engineering |
|---|---|
| المؤلفون: | Michelle Rene McCullers |
| المصدر: | The Owl, Vol 6, Iss 1 (2016) |
| بيانات النشر: | Florida State Open Publishing, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Social Sciences LCC:Science LCC:Fine Arts |
| مصطلحات موضوعية: | epigenetics, macrosatellite, FSHD, gene regulation, Social Sciences, Science, Fine Arts |
| الوصف: | The field of genomic engineering and manipulation has made great strides in recent years in the developing techniques to alter the genome to alleviate disease by flexing control on an epigenetic scale. Facioscapulohumeral muscular dystrophy (FSHD) poses a series of points in its pathophysiology to examine the utility of these manipulation techniques. This paper specifically focuses on how three approaches can be applied to ultimately stop the expression of the full length double homeobox 4 DUX4 gene transcript which is thought to be responsible for the upper body muscular atrophy exhibited in most FSHD cases. With this information, we can surmise what the future holds in terms of our thoughts on the purpose of repetitive DNA, the role of epigenetics in disease, and how to apply new genetic engineering techniques in creative ways. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2693-5759 2693-5783 |
| العلاقة: | https://journals.flvc.org/owl/article/view/87222Test; https://doaj.org/toc/2693-5759Test; https://doaj.org/toc/2693-5783Test |
| الوصول الحر: | https://doaj.org/article/f363dad94d9e44d98b29059df6c6f1beTest |
| رقم الانضمام: | edsdoj.f363dad94d9e44d98b29059df6c6f1be |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 26935759 26935783 |
|---|