Post‐mastectomy surveillance of BRCA1 / BRCA 2 mutation carriers: Outcomes from a specialized clinic for high‐risk breast cancer patients
| العنوان: | Post‐mastectomy surveillance of BRCA1 / BRCA 2 mutation carriers: Outcomes from a specialized clinic for high‐risk breast cancer patients |
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| المؤلفون: | Osnat Halshtok, Nayroz Kanana, Renata Faermann, Eitan Friedman, Noam Nissan, Meirav A Ben David, Eyal Klang, Dov Zippel, Orit Kaidar-Person, Mohammad Yassin, David Samoocha, Yael Yagil, Miri Sklair Levy, Anat Shalmon, Michael Gotlieb, Tima Davidson, Dana Madorsky Feldman |
| المساهمون: | RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie |
| المصدر: | Breast journal, 27(5), 441-447. Wiley-Blackwell |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Heterozygote, medicine.medical_specialty, endocrine system diseases, Breast imaging, medicine.medical_treatment, Genes, BRCA2, surveillance scheme, Breast Neoplasms, Disease, Asymptomatic, 030218 nuclear medicine & medical imaging, breast cancer risk, 03 medical and health sciences, brca1, 0302 clinical medicine, Breast cancer, Post mastectomy, risk‐, Internal Medicine, Humans, Medicine, skin and connective tissue diseases, mri, Retrospective Studies, BRCA2 Protein, BRCA2 mutation carriers, BRCA1 Protein, business.industry, mastectomy, reducing surgery, Retrospective cohort study, medicine.disease, Surgery, Oncology, 030220 oncology & carcinogenesis, Mutation, Mutation (genetic algorithm), Female, medicine.symptom, business, Mastectomy |
| الوصف: | Female BRCA1/BRCA2 mutation carriers may elect bilateral risk-reducing mastectomy. There is a paucity of data on yield of imaging surveillance after risk-reducing mastectomy. This retrospective study focused on female BRCA1/BRCA2 mutation carriers who underwent bilateral mastectomy either as primary preventative, or as secondary preventative, after breast cancer diagnosis. All participants underwent breast imaging at 6- to 12-month intervals after mastectomy. Data on subsequent breast cancer diagnosis and timing were collected and compared between the groups. Overall, 184 female mutation carriers (134 BRCA1, 45 BRCA2, 5 both BRCA genes) underwent bilateral mastectomy after initial breast cancer diagnosis, between April 1, 2009 and August 31, 2018. During a mean follow-up of 6.2 +/- 4.2 years, 13 (7.06%) were diagnosed with breast cancer; 12 ipsilateral (range: 0.4-28.8 years) and 1 contralateral breast cancer, 15.9 years after surgery. On the contrary, among asymptomatic BRCA1 (n = 40) and BRCA2 (n = 13) mutation carriers who underwent primary risk-reducing mastectomy (mean age at surgery 39.5 +/- 8.4 years); none has developed breast cancer after a mean follow-up of 5.4 +/- 3.4 years. BRCA1/BRCA2 mutation carriers with prior disease who underwent risk-reducing mastectomy after breast cancer diagnosis are still prone for developing ipsi or contralateral breast cancer, and therefore may benefit from continues clinical and imaging surveillance, unlike BRCA1/BRCA2 mutation carriers who undergo primary preventative bilateral mastectomy. |
| تدمد: | 1524-4741 1075-122X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05621115b7d4c5694c6a4b9e15433a9fTest https://doi.org/10.1111/tbj.14190Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....05621115b7d4c5694c6a4b9e15433a9f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244741 1075122X |
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