التفاصيل البيبلوغرافية
| العنوان: |
Hypofibrinogenemia is an independent predictor of hemophagocytic lymphohistiocytosis in children with sepsis. |
| المؤلفون: |
Luo, Xin, Zhou, Chentao, Ji, Cunwei, Lu, Chunmin, Luo, Yasha, Chen, Zhenhui, Zhong, Tianhua, Ye, Ruoting, Zeng, Liwei, Luo, Mingyong |
| المصدر: |
Scientific Reports; 11/18/2023, Vol. 13 Issue 1, p1-6, 6p |
| مصطلحات موضوعية: |
HEMOPHAGOCYTIC lymphohistiocytosis, SEPSIS, ASPARTATE aminotransferase, LACTATE dehydrogenase, REFERENCE values, FEVER |
| مصطلحات جغرافية: |
GUANGDONG Sheng (China) |
| مستخلص: |
Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening condition in children with sepsis. We herein aimed to identify clinical and laboratory predictors of HLH in children with sepsis. We conducted a retrospective study of 568 children with sepsis admitted to Guangdong Women and Children Hospital from January 2019 to June 2022. HLH, while rare (6.34%), proved to be a highly fatal complication (37.14%) in children with sepsis. Children with HLH had higher levels of aspartate aminotransferase, lactate dehydrogenase, triglycerides, and ferritin than children without HLH; conversely, they displayed decreased levels of neutrophils, hemoglobin, platelets, fibrinogen, and albumin. Additionally, the HLH group showed higher rates of prolonged fever (> 10 days), hepatomegaly, and splenomegaly than the non-HLH group. Our retrospective analysis identified hypofibrinogenemia (OR = 0.440, P = 0.024) as an independent predictor for the development of HLH in patients with sepsis. The optimal cutoff value for fibrinogen was found to be < 2.43 g/L. The area under the curve for diagnosing HLH was 0.80 (95% confidence interval: 0.73–0.87, P < 0.0001), with a sensitivity of 72.41% and specificity of 76.27%. Thus, hypofibrinogenemia emerges as a potentially valuable predictor for HLH in children with sepsis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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