دورية أكاديمية
Real world effectiveness of standard of care triple therapy versus two-drug combinations for treatment of people living with HIV
| العنوان: | Real world effectiveness of standard of care triple therapy versus two-drug combinations for treatment of people living with HIV |
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| المؤلفون: | Teira, Ramón, Diaz-Cuervo, Helena, Aragão, Filipa, Marguet, Sophie, de la Fuente, Belén, Muñoz, Maria Jose, Ribera Pascuet, Esteve |
| المساهمون: | Institut Català de la Salut, Teira R Hospital de Sierrallana, Torrelavega, Spain. Diaz-Cuervo H Gilead Sciences, Medical Affairs, Stockley Park HEOR, Spain. Aragão F Maple Health Group, New York, New York, United States of America. NOVA National School of Public Health, Public Health Research Centre, Universidade NOVA de Lisboa, Lisboa, Portugal. Marguet S Amaris Consulting, Health Economics and Market Access (HEMA), Levallois-Perret, France. de la Fuente B Hospital de Cabueñes, Gijón, Spain. Muñoz MJ Hospital de Basurto, Bilbao, Spain. Ribera E Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Persones seropositives, Medicaments - Administració, Medicaments - Eficàcia, ORGANISMS::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Drug Therapy, Combination, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome, ORGANISMOS::virus::virus ARN::Retroviridae::Lentivirus::Lentivirus de los primates::VIH, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::farmacoterapia combinada, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento |
| الوصف: | Teràpia antiretroviral; Diagnòstic i gestió del VIH; Teràpia amb inhibidors de la proteasa ; Terapia antirretroviral; Diagnóstico y gestión del VIH; Terapia con inhibidores de la proteasa ; Antiretroviral therapy; HIV diagnosis and management; Protease inhibitor therapy ; Background Since 1996, the standard of care (SOC) therapy for HIV treatment has consisted of a backbone of two nucleoside analogue reverse transcriptase inhibitors (NRTI) paired with a third agent. Use of two-drug combinations (2DC) has been considered for selected patients to avoid toxicities associated with the use of NRTIs. This study aimed to compare the real-world outcomes of integrase strand transfer inhibitor (INSTI)-containing triple therapy (TT) to dolutegravir- (DTG) and/or boosted protease inhibitor (bPI)-based 2DC in a large Spanish cohort of HIV patients. Methods A retrospective analysis was performed using data from the VACH cohort, a prospective multicentre Spanish cohort of adult HIV patients. All treatment experienced patients initiating a TT of an INSTI combined with two NRTIs or a 2DC-containing DTG and/or a bPI between 01/01/2012 and 01/06/2017 were included. The unit of analysis was patient-regimens. The overall sample analysis was complemented with two sub-analyses. The first sub-analysis focused on patients treated with a backbone plus DTG compared to those treated with DTG+ one other antiretroviral. The second sub-analysis focused on patients with HIV RNA<50 copies/mL at baseline, irrespective of the regimen used. The following endpoints were assessed: time to discontinuation for any reason, time to switch due to virologic failure, and time to switch due to toxicity (reasons for discontinuation according to clinician report in the database). Time-to-event analyses were conducted using Kaplan–Meier survival curves and Cox regression models. Results Overall 7,481 patients were included in the analysis, contributing to 9,243 patient-regimens. Patient characteristics at baseline differed among groups, with the 2DC group ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | PLoS ONE;16(4); https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249515Test; Teira R, Diaz-Cuervo H, Aragão F, Marguet S, de la Fuente B, Muñoz MJ, et al. Real world effectiveness of standard of care triple therapy versus two-drug combinations for treatment of people living with HIV. PLoS One. 2021 Apr 8;16(4):e0249515.; https://hdl.handle.net/11351/5980Test |
| DOI: | 10.1371/journal.pone.0249515 |
| الإتاحة: | https://doi.org/10.1371/journal.pone.0249515Test https://hdl.handle.net/11351/5980Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9FDAFAD9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0249515 |