Multisystem Langerhans cell histiocytosis in an adult non‐smoker treated with steroid therapy
| العنوان: | Multisystem Langerhans cell histiocytosis in an adult non‐smoker treated with steroid therapy |
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| المؤلفون: | Takashi Ogura, Koji Okudera, Haruka Ito, Yukio Kakuta, Masaru Ito, Takeshi Kaneko |
| المصدر: | Respirology Case Reports, Vol 8, Iss 6, Pp n/a-n/a (2020) Respirology Case Reports |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Exacerbation, Case Report, Computed tomography, Case Reports, 03 medical and health sciences, 0302 clinical medicine, Langerhans cell histiocytosis, medicine, lcsh:RC705-779, Lung, medicine.diagnostic_test, business.industry, Oral mucosal lesions, transbronchial lung cryobiopsy, lcsh:Diseases of the respiratory system, medicine.disease, Corticosteroid therapy, Submandibular gland, Pneumonia, medicine.anatomical_structure, Steroid therapy, 030228 respiratory system, 030220 oncology & carcinogenesis, non‐smoker, business |
| الوصف: | We describe the case of a 29‐year‐old female non‐smoker who was treated with steroid therapy for a subacute exacerbation of multisystem Langerhans cell histiocytosis (MS‐LCH) with worsening lung, skin, and oral mucosal lesions. The patient developed pneumonia, and computed tomography (CT) showed multiple thin‐walled cavities. Transbronchial lung cryobiopsy (TBLC) specimens revealed Langerhans cells, which were positive for CD1a and S‐100 expression. Similar histological findings were detected in the submandibular gland, skin, and tooth. On the basis of these findings, the patient was diagnosed with MS‐LCH and subsequently treated with steroid therapy. From the literature review, case reports of non‐smokers with pulmonary lesions that worsened and required treatment are rare. Almost all cases recurred and needed additional treatment. This case study contributes to our understanding of the potential role of steroid therapy in MS‐LCH treatment. Additionally, TBLC is a novel, potentially safer, diagnostic tool that has not been previously described for LCH. Multisystem Langerhans cell histiocytosis in an adult non‐smoker treated with steroid therapy for a subacute exacerbation: a case report and review of the literature. |
| تدمد: | 2051-3380 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a8a356990d870cf5561c52cc3fc136Test https://doi.org/10.1002/rcr2.603Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....92a8a356990d870cf5561c52cc3fc136 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20513380 |
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