نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

المساهمون: Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 37, Iss, Pp 100991-(2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Acylation, GLP-1RA, glucagon-like peptide-1 receptor agonist, Pharmacology, 0601 Biochemistry and Cell Biology, law.invention, Mice, 0302 clinical medicine, n.c., not calculable, law, Glucagon-Like Peptide 1, Receptors, Glucagon, Receptor, TR-FRET, time-resolved Förster resonance energy transfer, Trafficking, Chemistry, Type 2 diabetes, Ligand (biochemistry), Glucagon-like peptide-1, 3. Good health, cAMP, cyclic adenosine monophosphate, FITC, fluorescein isothiocyanate, Signal Transduction, lcsh:Internal medicine, PBS, phosphate-buffered saline, 030209 endocrinology & metabolism, T2D, type 2 diabetes, AUC, area under curve, Brief Communication, SEM, standard error of the mean, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Pharmacokinetics, Confocal microscopy, In vivo, Potency, Animals, Humans, HTRF, homogenous time-resolved fluorescence, lcsh:RC31-1245, HBSS, Hank's buffered salt solution, Molecular Biology, Biased signalling, Dose-Response Relationship, Drug, Exendin-4, Cell Biology, DIO, diet-induced obesity, LC/MSMS, liquid chromatography/tandem mass spectrometry, 0606 Physiology, Peptide Fragments, 030104 developmental biology, Glucose, HEK293 Cells, Exenatide, Blood sugar regulation, BSA, bovine serum albumin, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eea458e3c27345ef8e319b61a8f529fTest
https://pubmed.ncbi.nlm.nih.gov/32278079Test

5

Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice

المؤلفون: James L. Trevaskis, Anthony Celeste, Michelle L. Boland, Sarah Will, Silvia Guionaud, Stephanie Oldham, Peter Ravn, Hani A. Jouihan

المصدر: Molecular Metabolism, Vol 6, Iss 11, Pp 1360-1370 (2017)
Molecular Metabolism

مصطلحات موضوعية: Liver Cirrhosis, Male, 0301 basic medicine, Steatosis, Mice, Obese, Receptors, Cytoplasmic and Nuclear, Mice, Random Allocation, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, AST, aspartate transaminase, Fibrosis, Medicine, Receptor, NASH, Obeticholic acid, OCA, obeticholic acid, BA, bile acid, Original Article, 030211 gastroenterology & hepatology, NASH, nonalcoholic steatohepatitis, Agonist, lcsh:Internal medicine, medicine.medical_specialty, Combination therapy, ALT, alanine transaminase, medicine.drug_class, Chenodeoxycholic Acid, digestive system, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Internal medicine, Weight Loss, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, Glucagon-like peptide 1 receptor, AMLN, Amylin liver NASH diet, OCA, FXR, farnesoid-X receptor, business.industry, Cell Biology, medicine.disease, digestive system diseases, LFD, low-fat diet, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, NAFLD, nonalcoholic fatty liver disease, Metabolic syndrome, GLP-1, business, GLP-1R, glucagon-like peptide-1 receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b193f9352937859ce0b26d1f29cca9Test
https://doi.org/10.1016/j.molmet.2017.09.001Test

6

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

المؤلفون: Alan G. Watts, Klaus G. Pettersen, Puck N. Norell, Angelica Pignalosa, Wolfgang Langhans, Graciela Sanchez-Watts, Dubravka Vrdoljak, Jean-Philippe Krieger, Scott E. Kanoski, Matthew R. Hayes, Shin J. Lee, Alyssa M. Cortella

المصدر: Molecular Metabolism
Molecular Metabolism, 11
Molecular Metabolism, Vol 11, Iss, Pp 33-46 (2018)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, lcsh:Internal medicine, endocrine system, Hypothalamus, Neuropeptide, Adipose tissue, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, 03 medical and health sciences, Adipose Tissue, Brown, Glucagon-Like Peptide 1, Internal medicine, Brown adipose tissue, medicine, Animals, Neuropeptide Y, Obesity, GABAergic Neurons, lcsh:RC31-1245, Molecular Biology, Sympathetic nerve, Uncoupling Protein 1, Adiposity, Chemistry, Lipogenesis, digestive, oral, and skin physiology, Thermogenesis, Cell Biology, Neuropeptide Y receptor, Thermogenin, Rats, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Exenatide, Original Article, Insulin Resistance, hormones, hormone substitutes, and hormone antagonists, Signal Transduction

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5c374da17a143c0bac08f1de04f7a9Test
http://europepmc.org/articles/PMC6001878Test

7

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

المؤلفون: Maria Lucey, Stavroula Bitsi, Alejandra Tomas, David J. Hodson, Roxana-Maria Rujan, Ivan R. Corrêa, Giuseppe Deganutti, Christopher A. Reynolds, Fiona B. Ashford, Emma Rose McGlone, Stephen R. Bloom, Phil Pickford, Tricia Tan, James Minnion, Ben Jones, Bryn M. Owen

المساهمون: Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes, British Society for Neuroendocrinology

المصدر: Molecular Metabolism, Vol 51, Iss, Pp 101242-(2021)
Molecular Metabolism

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Pharmacology, 0601 Biochemistry and Cell Biology, Biased agonism, Mice, chemistry.chemical_compound, 0302 clinical medicine, Receptors, Glucagon, Functional selectivity, Glucose homeostasis, Internal medicine, Cells, Cultured, Partial agonism, beta-Arrestin 2, Oxyntomodulin, Original Article, medicine.drug, Agonist, medicine.drug_class, Primary Cell Culture, 030209 endocrinology & metabolism, Partial agonist, Glucagon-Like Peptide-1 Receptor, Islets of Langerhans, 03 medical and health sciences, Downregulation and upregulation, Weight Loss, medicine, Animals, Humans, Hypoglycemic Agents, Molecular Biology, β-arrestin, Liraglutide, Cell Biology, 0606 Physiology, Glucagon, RC31-1245, Rats, Disease Models, Animal, HEK293 Cells, 030104 developmental biology, Diabetes Mellitus, Type 2, chemistry, Hepatocytes, Peptides, GLP-1, Glucagon receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936d765d0c32a8bfff7f69a1a7ee38bcTest
https://doi.org/10.1016/j.molmet.2021.101242Test

8

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

المؤلفون: Andreas Ludwig, Xiemin Cao, Alexandra Mighiu, Scott P. Heximer, M. Golam Kabir, Randy J. Seeley, Erin E. Mulvihill, Daniel J. Drucker, Hangjun Zhang, John R. Ussher, Brent A. McLean, Laurie L. Baggio

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 11, Pp 1339-1349 (2017)

مصطلحات موضوعية: Male, 0301 basic medicine, Chronotropic, lcsh:Internal medicine, endocrine system, medicine.medical_specialty, Heart rate, 030209 endocrinology & metabolism, Propranolol, Autonomic Nervous System, Glucagon-Like Peptide-1 Receptor, Mice, 03 medical and health sciences, Lixisenatide, chemistry.chemical_compound, 0302 clinical medicine, Glucagon-Like Peptide 1, Internal medicine, medicine, Animals, lcsh:RC31-1245, Molecular Biology, Liraglutide, Sinoatrial node, business.industry, Diabetes, digestive, oral, and skin physiology, Cell Biology, Cardiovascular disease, 3. Good health, Mice, Inbred C57BL, Autonomic nervous system, Atropine, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Original Article, Peptides, GLP-1, business, Cardiac, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e284da5ec9643fddb4983c72727de4a6Test
https://doi.org/10.1016/j.molmet.2017.08.010Test

9

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

المساهمون: Mokrosinski, Jacek [0000-0001-5008-0457], Reimann, Frank [0000-0001-9399-6377], Gribble, Fiona [0000-0002-4232-2898], Apollo - University of Cambridge Repository

المصدر: Rudenko, O, Shang, J, Munk, A, Ekberg, J P, Petersen, N, Engelstoft, M S, Egerod, K L, Hjorth, S A, Wu, M, Feng, Y, Zhou, Y-P, Mokrosinski, J, Thams, P, Reimann, F, Gribble, F, Rehfeld, J F, Holst, J J, Treebak, J T, Howard, A D & Schwartz, T W 2019, ' The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones ', Molecular Metabolism, vol. 19, pp. 49-64 . https://doi.org/10.1016/j.molmet.2018.10.012Test

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_treatment, Mice, Obese, Enteroendocrine cell, Glucose homeostasis, Trp, Receptors, G-Protein-Coupled, chemistry.chemical_compound, Mice, 0302 clinical medicine, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Receptors, Glucagon, Insulin, Mice, Knockout, Glycogen, Chemistry, Tryptophan, medicine.anatomical_structure, hormones, hormone substitutes, and hormone antagonists, Agonist, endocrine system, medicine.medical_specialty, G-protein-coupled receptor, GPR142, medicine.drug_class, 030209 endocrinology & metabolism, Glucagon, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Amino Acids, Aromatic, Islets of Langerhans, Receptor-Interacting Protein Serine-Threonine Kinase 2, Internal medicine, medicine, Animals, Amino acid sensing, Molecular Biology, Pancreatic islets, Cell Biology, Rats, Rats, Zucker, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Glucose, Glucagon-Secreting Cells, Hormone

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f1db027dfe484c01950af736ab3092Test
https://pubmed.ncbi.nlm.nih.gov/30472415Test

10

Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites

المؤلفون: Elvar Theodorsson, Bhavik Anil Patel, Thue W. Schwartz, Mari L. Lund, Maja S. Engelstoft, Kristoffer L. Egerod, Oksana Dmytriyeva

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 11, Iss, Pp 70-83 (2018)
Lund, M L, Egerod, K L, Engelstoft, M S, Dmytriyeva, O, Theodorsson, E, Patel, B A & Schwartz, T W 2018, ' Enterochromaffin 5-HT cells-A major target for GLP-1 and gut microbial metabolites ', Molecular Metabolism, vol. 11, pp. 70-83 . https://doi.org/10.1016/j.molmet.2018.03.004Test

مصطلحات موضوعية: 0301 basic medicine, Male, lcsh:Internal medicine, Serotonin, Metabolite GPCR, Nutrient sensing, Gut microbiota, Gut hormone, Enteroendocrine, Afferent vagal nerves, Enteroendocrine cell, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Mice, Glucagon-Like Peptide 1, Free fatty acid receptor 1, medicine, Enterochromaffin Cells, Animals, lcsh:RC31-1245, Receptor, Molecular Biology, Cells, Cultured, biology, Chemistry, Fatty Acids, Biochemistry and Molecular Biology, Chromogranin A, Cell Biology, G protein-coupled bile acid receptor, Small intestine, Gastrointestinal Microbiome, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Biochemistry, Enterochromaffin cell, biology.protein, Original Article, Biokemi och molekylärbiologi, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ba59cfd5a42c2d75a88f87dd8f0691Test
https://pubmed.ncbi.nlm.nih.gov/29576437Test

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