دورية أكاديمية
Change in PSA velocity is a predictor of overall survival in men with biochemically-recurrent prostate cancer treated with nonhormonal agents: combined analysis of four phase-2 trials.
| العنوان: | Change in PSA velocity is a predictor of overall survival in men with biochemically-recurrent prostate cancer treated with nonhormonal agents: combined analysis of four phase-2 trials. |
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| المؤلفون: | Suzman, D L, Zhou, X C, Zahurak, M L, Lin, Jianqing, MD, Antonarakis, E S |
| المصدر: | Kimmel Cancer Center Faculty Papers |
| بيانات النشر: | Jefferson Digital Commons |
| سنة النشر: | 2015 |
| المجموعة: | Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
| مصطلحات موضوعية: | Kimmel Cancer Center, Thomas Jefferson University Hospital, adult, age, androgen deprivation therapy, Article, biochemically recurrent prostate cancer, cancer hormone therapy, cancer screening, cancer survival, controlled study, follow up, Gleason score, human, major clinical study, male, oncological parameters, outcome assessment, overall survival, phase 1 clinical trial, phase 2 clinical trial, prediction, prostate cancer, PSA doubling time, PSA slope, PSA velocity, randomized controlled trial, retrospective study, Oncology |
| الوصف: | BACKGROUND: Multiple phase-2 trials in men with biochemically-recurrent prostate cancer (BRPC) have assessed the impact of nonhormonal agents on PSA kinetics. We have previously demonstrated that changes in PSA kinetics correlate with metastasis-free survival; however, it is unknown whether these changes also correlate with overall survival (OS). METHODS: We performed a combined retrospective analysis of 146 men with BRPC treated on phase-2 trials using one of four investigational drugs: lenalidomide (n=60), marimastat (n=39), ATN-224 (n=22) and imatinib (n=25). We examined factors influencing OS, including within-subject changes in PSA kinetics (PSA slope, PSA doubling time and PSA velocity), before and 6 months after treatment initiation. RESULTS: After a median follow-up of 83.1 months, 49 of 146 men had died. In univariate Cox regression analysis, two factors were associated with OS: baseline PSA velocity and change in PSA velocity on therapy. In a landmark multivariable model, stratified by study (which controlled for age, Gleason score, type of local therapy and use of androgen-deprivation therapy prior to metastases), baseline PSA velocity and increase in PSA velocity on therapy remained independent predictors of OS. Median OS for men with an increase in PSA velocity on treatment was 115.4 months and was not reached for men with a decrease in PSA velocity (hazard ratio=0.47, 95% confidence interval 0.25-0.88; P=0.02). CONCLUSIONS: This hypothesis-generating study suggests that within-subject changes in PSA velocity after initiation of nonhormonal therapy may correlate with OS in men with BRPC. If validated in prospective trials, change in PSA velocity may represent a reasonable intermediate end point for screening new agents in these patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://jdc.jefferson.edu/kimmelccfp/54Test; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323734Test/ |
| الإتاحة: | https://jdc.jefferson.edu/kimmelccfp/54Test http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323734Test/ |
| رقم الانضمام: | edsbas.667DD220 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |