دورية
Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD
| العنوان: | Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD |
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| المؤلفون: | Bullen, Alexander L., Ascher, Simon B., Scherzer, Rebecca, Garimella, Pranav S., Katz, Ronit, Hallan, Stein I., Cheung, Alfred K., Raphael, Kalani L., Estrella, Michelle M., Jotwani, Vasantha K., Malhotra, Rakesh, Seegmiller, Jesse C., Shlipak, Michael G., Ix, Joachim H. |
| المصدر: | Journal of the American Society of Nephrology; October 2022, Vol. 33 Issue: 10 p1915-1926, 12p |
| مستخلص: | SPRINT demonstrated in individuals with hypertension and high cardiovascular disease (CVD) risk that intensive BP lowering was associated with decreased risk of CVD events and all-cause mortality. However, it was also associated with increased risk of adverse events (AEs), particularly among those with CKD. Thus, the ability to identify individuals at higher risk for these AEs is paramount. We used ten novel endogenous markers to evaluate the association between tubular secretion and elevated risk of AEs. We found that lower tubular secretion was associated with higher risk of AEs, independent of eGFR and albuminuria. Assessment of kidney tubule health, including tubular secretion, may provide new opportunities to understand the kidney?s role in adverse health outcomes. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 10466673 15333450 |
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| DOI: | 10.1681/ASN.2022010117 |