High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER
| العنوان: | High Incidence of Distant Metastasis Is Associated With Histopathological Subtype of Pediatric Papillary Thyroid Cancer - a Retrospective Analysis Based on SEER |
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| المؤلفون: | Dalin Zhang, Ting Zhang, Ping Zhang, Mengsu Cao, Liang Shao, Jiapeng Huang, Hao Zhang, Zhihong Wang, Chengzhou Lv, Wei Sun, Wenwu Dong, Jingzhe Xiang, Xue Zeng, Zhiqiang Gui, Liang He |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Carcinoma, Papillary, Follicular, Logistic regression, Diseases of the endocrine glands. Clinical endocrinology, Papillary thyroid cancer, Thyroid carcinoma, Endocrinology, distant metastasis, Risk Factors, pediatrics - children, CPTC, Internal medicine, medicine, Humans, Thyroid Neoplasms, Child, Retrospective Studies, Original Research, Receiver operating characteristic, business.industry, Mortality rate, Incidence (epidemiology), Incidence, histopathological subtype, Distant metastasis, medicine.disease, RC648-665, Carcinoma, Papillary, SEER, Logistic Models, Thyroid Cancer, Papillary, Lymphatic Metastasis, Propensity score matching, FVPTC, Thyroidectomy, Female, papillary thyroid carcinoma (PCT), business |
| الوصف: | ObjectiveChildren with papillary thyroid cancer (PTC) have a higher invasive rate and distant metastasis rate, but the mortality rate is lower with unknown reasons. The majority of PTC cases comprise classical papillary thyroid carcinoma (CPTC) and follicular variant papillary thyroid carcinoma (FVPTC). This study aimed to determine the relationship between histopathological subtype and rate of distant metastasis and investigate factors influencing distant metastasis in pediatric PTC.MethodsA total of 102,981 PTC patients were recruited from SEER registry, 2004-2015. Proportion of distant metastasis between children (≤18 years) and adults with different histopathological subtypes was compared by propensity score matching. The cut-off age for distant metastasis in children was calculated by receiver operating characteristic (ROC) curve, and the risk factors for distant metastasis in pediatric patients were analyzed by logistic regression models.ResultsAmong the 1,484 children and 101,497 adults included in the study, the incidence of CPTC patients with distant metastasis in children was higher than that in adults (p18 years) (both pp=0.006). There was no difference between the proportion of CPTC and FVPTC with distant metastasis in adolescents (17-18 years) and adults. Logistic regression models revealed that extrathyroidal extension, lymph node metastasis and CPTC histopathological subtype were risk factors for distant metastasis in young children aged 2 -16 years.ConclusionsIn CPTC, the incidence of distant metastasis in young children (2-16 years) was significantly higher than that in adolescents (17-18 years) and adults (>18 years). In patients with distant metastasis aged 2-16 years, the proportion of CPTC was higer than that of FVPTC. Extrathyroidal extension, lymph node metastasis, and CPTC histopathological subtype were risk factors for distant metastasis in young children aged 2-16 years. |
| تدمد: | 1664-2392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146ca2263d1280f5d6bfb103f01f3ef5Test https://pubmed.ncbi.nlm.nih.gov/34858334Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....146ca2263d1280f5d6bfb103f01f3ef5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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