Food allergy severity predictions based on cellular in vitro tests
| العنوان: | Food allergy severity predictions based on cellular in vitro tests |
|---|---|
| المؤلفون: | Betul Buyuktiryaki, Alexandra F. Santos |
| المصدر: | Expert Review of Molecular Diagnostics. 20:679-691 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Risk, 0301 basic medicine, Arachis, Peanut allergy, Antibody Affinity, Basophil Degranulation Test, macromolecular substances, In Vitro Techniques, Immunoglobulin E, Severity of Illness Index, Cell Degranulation, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Antibody Specificity, Food allergy, Genetics, medicine, Humans, Nuts, Mast Cells, Child, Anaphylaxis, Molecular Biology, Skin Tests, biology, business.industry, musculoskeletal, neural, and ocular physiology, digestive, oral, and skin physiology, Allergens, medicine.disease, Basophils, 030104 developmental biology, nervous system, 030220 oncology & carcinogenesis, Immunology, biology.protein, Molecular Medicine, Milk Hypersensitivity, business, Food Hypersensitivity |
| الوصف: | Food allergy is increasing in prevalence and the severity of allergic reactions is unpredictable. Identifying food-allergic patients at high risk of severe reactions would allow us to offer a personalized and improved management for these patients.We review the evidence for using the levels of specific IgE, the nature of the allergen, and cellular tests to identify patients at high risk of developing severe allergic reactions to foods.The evidence about whether the quantity of allergen-specific IgE reflects the severity of allergic reactions to foods is conflicting, with some positive and some negative studies. For some foods, specific IgE to individual components (e.g. Ara h 2 in peanut) can provide additional information. However, more important than the quantity of IgE is possibly the quality of IgE, which can be captured by individual measurements of affinity/avidity, diversity, and specific activity, but is best measured overall using the basophil and mast cell activation tests, which assess the function of IgE in its ability to induce cell activation, degranulation, and mediator release. Biomarkers look at a single aspect of the allergic response and should be interpreted in the broader clinical context for each individual patient assessed. |
| تدمد: | 1744-8352 1473-7159 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca47f841b8ac1e3cce2663c905590dcTest https://doi.org/10.1080/14737159.2020.1782192Test |
| رقم الانضمام: | edsair.doi.dedup.....9ca47f841b8ac1e3cce2663c905590dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448352 14737159 |
|---|