Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells-ACHN and A2780/cp cell lines
| العنوان: | Cheminformatics-based selection and synergism of herbal extracts with anticancer agents on drug resistance tumor cells-ACHN and A2780/cp cell lines |
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| المؤلفون: | Mohammad Ali Shokrgozar, Soroush Sardari, Ghazaleh Ghavami |
| المساهمون: | Drug Design and Bioinformatics Unit, Institut Pasteur d'Iran, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Eastern Mediterranean Health Genomics and Biotechnology Network (EMGEN), Eastern Mediterranean Health Genomics and Biotechnology Network, Biotechnology Research Center, Réseau International des Instituts Pasteur (RIIP) |
| المصدر: | Computers in Biology and Medicine Computers in Biology and Medicine, Elsevier, 2011, 41 (8), pp.665-74. ⟨10.1016/j.compbiomed.2011.06.002⟩ |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | MESH: Informatics, Erythrocytes, Informatics, Drug resistance, Pharmacology, Bioinformatics, 030226 pharmacology & pharmacy, MESH: Drug Synergism, 0302 clinical medicine, Medicine, MESH: Animals, Cytotoxicity, MESH: Inhibitory Concentration 50, Ovarian Neoplasms, 0303 health sciences, Drug discovery, Cheminformatics, MESH: Erythrocytes, Drug Synergism, Boraginaceae, MESH: Hemolysis, MESH: Drug Resistance, Neoplasm, Drug Resistance, Multiple, Kidney Neoplasms, 3. Good health, Computer Science Applications, MESH: Ovarian Neoplasms, Anticancer, Herbal extract, MESH: Morus, Female, medicine.drug, MESH: Computational Biology, MESH: Cell Line, Tumor, In silico, MESH: Plant Extracts, MESH: Sheep, Health Informatics, Antineoplastic Agents, Adenocarcinoma, Hemolysis, MESH: Drug Resistance, Multiple, 03 medical and health sciences, MESH: Doxorubicin, Inhibitory Concentration 50, MESH: Musa, Cell Line, Tumor, Animals, Humans, Doxorubicin, 030304 developmental biology, MESH: Humans, Sheep, business.industry, Plant Extracts, MESH: Adenocarcinoma, Synergism, Computational Biology, Musa, Multiple drug resistance, MESH: Boraginaceae, MESH: Cisplatin, Drug Resistance, Neoplasm, Cancer cell, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH: Antineoplastic Agents, Morus, MESH: Kidney Neoplasms, Cisplatin, business, MESH: Female |
| الوصف: | The treatment of cancer usually involves lethal effect on normal body cells as side effects. Cheminformatics methodology can play a significant role in biomed/clinical scientific research. Similarity searching is a standard cheminformatics tool in drug discovery area and database design. In this study, five novel herbal extracts in combination with doxorubicin and cisplatin have been used to sensitize ACHN and A2780/cp cells. These herbal extracts have been selected on the basis of novel cheminformatics methodology and assayed for the first time. The findings confirmed predicted outcomes from the in silico research and the results introduced may bring to use the effects of these herbs in reversing of multidrug resistance (MDR) phenomenon. Highlights? These herbal extracts have been selected on the basis of novel cheminformatics methodology and assayed for the first time. ? Results introduce selectivity effect of extract in inducing cytotoxicity on cancerous cell lines with synergistic effect. ? The findings confirmed that in silico predictions can bring to use the effects of these herbs in reversing of MDR phenomenon. |
| تدمد: | 1879-0534 0010-4825 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee85e504fb7f70374527b2af8762101Test https://pubmed.ncbi.nlm.nih.gov/21752359Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....eee85e504fb7f70374527b2af8762101 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18790534 00104825 |
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