التفاصيل البيبلوغرافية
| العنوان: |
Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications. |
| المؤلفون: |
Legrand, Matthieu, Ludes, Pierre-Olivier, Massy, Ziad, Rossignol, Patrick, Parenica, Jiri, Park, Jin-Joo, Ishihara, Shiro, AlHabib, Khalid F., Maggioni, Aldo, Miró, Òscar, Sato, Naoki, Cohen-Solal, Alain, Fairman, Enrique, Lassus, Johan, Harjola, Veli-Pekka, Mueller, Christian, Peacock, Franck W., Choi, Dong-Ju, Plaisance, Patrick, Spinar, Jindřich |
| المصدر: |
Clinical Research in Cardiology; Mar2018, Vol. 107 Issue 3, p214-221, 8p |
| مستخلص: |
Background: The interaction between chronic medications on admission and the association between serum potassium level and outcome in patients with acute heart failure (AHF) are unknown.Methods: Observational intercontinental study of patients admitted with AHF. 15954 patients were included from 12 cohorts in 4 continents. Main outcome was 90-day mortality. Clinical presentation (medication use, hemodynamics, comorbidities), demographic, echocardiographic, and biochemical data on admission were recorded prospectively in each cohort, with prospective adjudication of outcomes.Results: Positive and negative linear relationships between 90-day mortality and sK+ above 4.5 mmol/L (hyperkalemia) and below 3.5 mmol/L (hypo-kalemia) were observed. Hazard ratio for death was 1.46 [1.34–1.58] for hyperkalemia and 1.22 [1.06–1.40] for hypokalemia. In a fully adjusted model, only hyperkalemia remained associated with mortality (HR 1.03 [1.02–1.04] for each 0.1 mmol/l change of sK+ above 4.5 mmol/L). Interaction tests revealed that the association between hyperkalemia and outcome was significantly affected by chronic medications. The association between hyperkalemia and mortality was absent for patients treated with beta blockers and in those with preserved renal function.Conclusions: In patients with AHF, sK+ > 4.5 mmol/L appears to be associated with 90-day mortality. B-blockers have potentially a protective effect in the setting of hyperkalemia. [ABSTRACT FROM AUTHOR] |
|
Copyright of Clinical Research in Cardiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
