دورية أكاديمية
Patterning and folding of intestinal villi by active mesenchymal dewetting.
| العنوان: | Patterning and folding of intestinal villi by active mesenchymal dewetting. |
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| المؤلفون: | Huycke, Tyler R, Häkkinen, Teemu J, Miyazaki, Hikaru, Srivastava, Vasudha, Barruet, Emilie, McGinnis, Christopher S, Kalantari, Ali, Cornwall-Scoones, Jake, Vaka, Dedeepya, Zhu, Qin, Jo, Hyunil, Oria, Roger, Weaver, Valerie M, DeGrado, William F, Thomson, Matt, Garikipati, Krishna, Boffelli, Dario, Klein, Ophir D, Gartner, Zev J |
| المصدر: | Cell ; ISSN:1097-4172 ; Volume:187 ; Issue:12 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Cahn-Hilliard, active fluids, biophysics, cell adhesion, development, extracellular matrix, morphogenesis, patterning, phase separation, self-organization |
| الوصف: | Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecular and mechanical processes driving villus morphogenesis remain unclear. Here, we identify an active mechanical mechanism that simultaneously patterns and folds the intestinal epithelium to initiate villus formation. At the cellular level, we find that PDGFRA+ subepithelial mesenchymal cells generate myosin II-dependent forces sufficient to produce patterned curvature in neighboring tissue interfaces. This symmetry-breaking process requires altered cell and extracellular matrix interactions that are enabled by matrix metalloproteinase-mediated tissue fluidization. Computational models, together with in vitro and in vivo experiments, revealed that these cellular features manifest at the tissue level as differences in interfacial tensions that promote mesenchymal aggregation and interface bending through a process analogous to the active dewetting of a thin liquid film. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.cell.2024.04.039Test; https://pubmed.ncbi.nlm.nih.gov/38781967Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166531Test/ |
| DOI: | 10.1016/j.cell.2024.04.039 |
| الإتاحة: | https://doi.org/10.1016/j.cell.2024.04.039Test https://pubmed.ncbi.nlm.nih.gov/38781967Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166531Test/ |
| حقوق: | Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.AE573136 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cell.2024.04.039 |
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