التفاصيل البيبلوغرافية
| العنوان: |
Ifosfamide/Mesna as Salvage Therapy in Platinum Pretreated Ovarian Cancer Patients—Long-Term Results of a Phase II Study. |
| المؤلفون: |
Baur, Martina, Fazeny-Doerner, B., Hudec, M., Sevelda, P., Salzer, H., Dittrich, Christian |
| المصدر: |
Cancer Investigation; 2006, Vol. 24 Issue 1, p22-27, 6p, 2 Charts |
| مصطلحات موضوعية: |
OVARIAN tumors, CANCER in women, CANCER treatment, DRUG therapy, ANTINEOPLASTIC agents, NEUROTOXICOLOGY |
| مستخلص: |
Purpose : Salvage chemotherapy in advanced ovarian cancer is not yet standardized. Patients : Twenty-one consecutive patients progressing on or relapsing after previous platinum-containing treatment were eligible for treatment with ifosfamide 5 g/m 2 infused over a 24-hour period every 3 weeks in a Phase II trial. After an initial bolus of 1 g/m 2 of mesna, mesna was applied at a dosage of 5 g/m 2 concomitantly with ifosfamide followed by additional dosages of 200 mg 3 times at 4-hour intervals after termination of the ifosfamide infusion. Results : The rate of objective responses was 19 percent, with a 95%CI [5.45–41.91 percent]. One patient achieved a pathologic complete remission (pCR) and 3 patients a clinical partial remission (PR). Median time-to-progression was 3 months. One patient was a long-term survivor. Main toxicities according to NCI-CTC included Grade 4 neurotoxicity in one patient, Grade 3 gastrointestinal toxicity in 5 patients, Grade 3 infection in one patient, and Grade 3 and 4 leucopenia in 6 and 2 patients, respectively. Conclusions : Monotherapy with ifosfamide represents an active regimen for salvage chemotherapy in advanced ovarian cancer patients progressing on or relapsing after previous platinum-pretreatment, even yielding a long-term surivor. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
