التفاصيل البيبلوغرافية
| العنوان: |
Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment. |
| المؤلفون: |
Park, Min Hee1,2,3, Baek, Bosung1,4, Jin, Hee Kyung1,4 hkjin@knu.ac.kr, Bae, Jae-sung1,2,3 jsbae@knu.ac.kr |
| المصدر: |
Animal Cells & Systems. Oct2018, Vol. 22 Issue 5, p281-288. 8p. |
| مصطلحات موضوعية: |
*NEUROPEPTIDE Y, *PEPTIDES, *CANCER chemotherapy, *BONE marrow, *HEMATOPOIETIC stem cells, *CISPLATIN |
| مستخلص: |
Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy. [ABSTRACT FROM AUTHOR] |
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