التفاصيل البيبلوغرافية
| العنوان: |
Systematic Evaluation of Endothelin 1 Measurement Relative to Traditional and Modern Biomarkers for Clinical Assessment and Prognosis in Patients With Chronic Systolic Heart Failure: Serial Measurement and Multimarker Testing. |
| المؤلفون: |
Gaggin, Hanna K., Truong, Quynh A., Gandhi, Parul U., Motiwala, Shweta R., Belcher, Arianna M., Weiner, Rory B., Baggish, Aaron L., Januzzi Jr., James L., Januzzi, James L Jr |
| المصدر: |
American Journal of Clinical Pathology; 2017, Vol. 147 Issue 5, p461-472, 12p, 4 Charts, 4 Graphs |
| مصطلحات موضوعية: |
PREPROENDOTHELIN, HEART failure, PROGNOSIS, CHRONIC diseases, COMPARATIVE studies, ECHOCARDIOGRAPHY, ENDOTHELINS, HEART diseases, IMMUNOASSAY, RESEARCH methodology, MEDICAL cooperation, PEPTIDE hormones, PEPTIDES, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, PROPORTIONAL hazards models |
| مستخلص: |
Objectives: To define the role of single or serial measurement of endothelin 1 (ET-1) for prognostication beyond traditional and modern markers of risk in heart failure (HF).Methods: In total, 115 patients with chronic systolic HF were followed for 10 months. Clinical assessment and ET-1, N-terminal pro-B-type natriuretic peptide (NT-proBNP), highly sensitive troponin I (hsTnI), soluble ST2 (sST2), and galectin 3 were measured at each visit.Results: Elevated ET-1 was associated with worse HF, lower right ventricular function, higher pulmonary pressure, and higher left atrial volume index despite similar left ventricular function. ET-1 correlated with angiotensin-converting enzyme inhibitor use. A model containing traditional risk factors, ET-1, NT-proBNP, hsTnI, and sST2 best predicted cardiovascular events, and ET-1 improved reclassification. In an adjusted time-integrated model, percent time spent with ET-1 of 5.90 pg/mL or less was predictive of fewer cardiovascular events (odds ratio, 0.75; 95% confidence interval, 0.62-0.91). ET-1 reduction over time was associated with a lower rate of cardiovascular events compared with increasing or stable ET-1 (24.4% vs 50.0%).Conclusions: ET-1 may be a unique predictor of HF prognosis, complementing other biomarkers in a multimarker profile. Serial measurement of ET-1 may provide additional prognostic information. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
