التفاصيل البيبلوغرافية
| العنوان: |
Expansion of highly interferon‐responsive T cells in early‐onset Alzheimer's disease |
| المؤلفون: |
Sirkis, Daniel W., Warly Solsberg, Caroline, Johnson, Taylor P., Bonham, Luke W., Oddi, Alexis P., Geier, Ethan G., Miller, Bruce L., Rabinovici, Gil D., Yokoyama, Jennifer S. |
| المساهمون: |
Rainwater Charitable Foundation, Alzheimer's Association, Global Brain Health Institute, Avid Radiopharmaceuticals, GE Healthcare, Genentech |
| المصدر: |
Alzheimer's & Dementia ; ISSN 1552-5260 1552-5279 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
INTRODUCTION Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early‐onset Alzheimer's disease (EOAD). METHODS We examined single‐cell RNA‐sequencing (scRNA‐seq) data from peripheral blood mononuclear cells (PBMCs) and droplet digital polymerase chain reaction (ddPCR) data from CD4 T cells from participants with EOAD and clinically normal controls. RESULTS We analyzed PBMCs from 16 individuals by scRNA‐seq and discovered increased interferon signaling‐associated gene (ISAG) expression and striking expansion of antiviral‐like ISAG hi T cells in EOAD. Isolating CD4 T cells from 19 individuals, including four cases analyzed by scRNA‐seq, we confirmed increased expression of ISAG hi marker genes. Publicly available cerebrospinal fluid leukocyte scRNA‐seq data from late‐onset mild cognitive impairment and AD also revealed increased expression of interferon‐response genes. DISCUSSION Antiviral‐like ISAG hi T cells are expanded in EOAD. Additional research into these cells and the role of heightened peripheral IFN signaling in neurodegeneration is warranted. Highlights Interferon‐responsive T cells expanded in early‐onset Alzheimer's disease (AD). Increased interferon‐associated gene expression present in early‐ and late‐onset AD. Peripheral immune changes in T and NK cells driven by females with early‐onset AD. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/alz.13892 |
| الإتاحة: |
https://doi.org/10.1002/alz.13892Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.4851C8DE |
| قاعدة البيانات: |
BASE |
