Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery
| العنوان: | Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery |
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| المؤلفون: | Hyun Beom Song, Won Jong Kim, Jeong Hun Kim, Hyung Woo Choi, Yonghwi Kim, Kimoon Kim, Ji-Hoon Kim, Jinhwan Kim |
| المصدر: | ACS Nano. 10:4199-4208 |
| بيانات النشر: | American Chemical Society (ACS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Chemistry, General Engineering, General Physics and Astronomy, Light irradiation, Nanoparticle, Nanotechnology, 02 engineering and technology, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Nitric oxide, chemistry.chemical_compound, Coating, Reagent, engineering, Light induced, General Materials Science, 0210 nano-technology, Mesoporous material, No release |
| الوصف: | We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery. |
| تدمد: | 1936-086X 1936-0851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d29f159807902502248bcfae7c97a5Test https://doi.org/10.1021/acsnano.5b07483Test |
| رقم الانضمام: | edsair.doi.dedup.....f7d29f159807902502248bcfae7c97a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936086X 19360851 |
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