دورية أكاديمية
COVID-19 and its impact on the cardiovascular system
| العنوان: | COVID-19 and its impact on the cardiovascular system |
|---|---|
| المؤلفون: | Mikhail, G, Khawaja, SA, Mohan, P, Jabbour, R, Bampouri, T, Bowsher, G, Hassan, AMM, Huq, F, Baghdasaryan, L, Wang, B, Sethi, A, Sen, S, Petraco, R, Ruparelia, N, Nijjer, S, Malik, IS, Foale, R, Bellamy, M, Kooner, J, Rana, BS, Cole, G, Sutaria, N, Kanaganayagam, G, Nihoyannopoulos, P, Fox, K, Plymen, CM, Pabari, P, Howard, L, Davies, R, Hajoi, G, Lo Giudice, F, Kanagaratnam, P, Anderson, J, Chukwuemeka, A, Khamis, R, Varnava, A, Baker, CSR, Francis, D, Asaria, P, Al-Lamee, R |
| المساهمون: | National Institute for Health Research, British Heart Foundation, Imperial College Healthcare NHS Trust- BRC Funding |
| المصدر: | 9 ; 1 |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, myocarditis, myocardial disease, acute coronary syndrome, arrhythmias, cardiac |
| الوصف: | Objectives: The clinical impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has varied across countries with varying cardiovascular manifestations. We review the cardiac presentations, in-hospital outcomes and development of cardiovascular complications in the initial cohort of SARS-CoV-2 positive patients at Imperial College Healthcare NHS Trust, United Kingdom. Methods: We retrospectively analysed 498 COVID-19 positive adult admissions to our institute from 7th March to 7th April 2020. Patient data was collected for baseline demographics, co-morbidities and in-hospital outcomes, especially relating to cardiovascular intervention. Results: Mean age was 67.4±16.1 years and 62.2%(n=310) were male. 64.1%(n=319) of our cohort had underlying cardiovascular disease (CVD) with 53.4%(n=266) having hypertension. 43.2%(n=215) developed acute myocardial injury. Mortality was significantly increased in those patients with myocardial injury (47.4% vs 18.4%,p<0.001). Only 4 COVID-19 patients had invasive coronary angiography,2 underwent percutaneous coronary intervention and 1 required a permanent pacemaker implantation. 7.0%(n=35) of patients had an inpatient echocardiogram. Acute myocardial injury (OR 2.39,1.31-4.40,p=0.005) and history of hypertension (OR 1.88 ,1.01-3.55,p=0.049) approximately doubled the odds of in-hospital mortality in patients admitted with COVID-19 after other variables had been controlled for. Conclusion: Hypertension, pre-existing CVD and acute myocardial injury were associated with increased in-hospital mortality in our cohort of COVID-19 patients. However, only a low number of patients required invasive cardiac intervention. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2053-3624 |
| العلاقة: | Open Heart; http://hdl.handle.net/10044/1/86254Test; RDB02 79560; FS/17/16/32560; RDB02 |
| DOI: | 10.1136/openhrt-2020-001472 |
| الإتاحة: | https://doi.org/10.1136/openhrt-2020-001472Test http://hdl.handle.net/10044/1/86254Test |
| حقوق: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0Test/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0Test/. ; http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.7515B659 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20533624 |
|---|---|
| DOI: | 10.1136/openhrt-2020-001472 |