المؤلفون: Southey, Melissa C, Goldgar, David E, Winqvist, Robert, Pylkäs, Katri, Couch, Fergus, Tischkowitz, Marc, Foulkes, William D, Dennis, Joe, Michailidou, Kyriaki, van Rensburg, Elizabeth J, Heikkinen, Tuomas, Nevanlinna, Heli, Hopper, John L, Dörk, Thilo, Claes, Kathleen Bm, Reis-Filho, Jorge, Teo, Zhi Ling, Radice, Paolo, Catucci, Irene, Peterlongo, Paolo, Tsimiklis, Helen, Odefrey, Fabrice A, Dowty, James G, Schmidt, Marjanka K, Broeks, Annegien, Hogervorst, Frans B, Verhoef, Senno, Carpenter, Jane, Clarke, Christine, Scott, Rodney J, Fasching, Peter A, Haeberle, Lothar, Ekici, Arif B, Beckmann, Matthias W, Peto, Julian, Dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Bolla, Manjeet K, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Miller, Nicola, Marme, Federik, Burwinkel, Barbara, Yang, Rongxi, Guénel, Pascal, Truong, Thérèse, Menegaux, Florence, Muir, Kenneth

المصدر: Southey , M C , Goldgar , D E , Winqvist , R , Pylkäs , K , Couch , F , Tischkowitz , M , Foulkes , W D , Dennis , J , Michailidou , K , van Rensburg , E J , Heikkinen , T , Nevanlinna , H , Hopper , J L , Dörk , T , Claes , K B , Reis-Filho , J , Teo , Z L , Radice , P , Catucci , I , Peterlongo , P , Tsimiklis , H , Odefrey , F A , Dowty , ....

مصطلحات موضوعية: Ataxia Telangiectasia Mutated Proteins, Breast Neoplasms, Case-Control Studies, Checkpoint Kinase 2, Fanconi Anemia Complementation Group N Protein, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Mutation, Nuclear Proteins, Ovarian Neoplasms, Prostatic Neoplasms, Risk, Tumor Suppressor Proteins, Journal Article, Multicenter Study

العلاقة: https://research.manchester.ac.uk/en/publications/b545a7d4-850d-4099-960a-7b6e321e0daaTest

الإتاحة: https://doi.org/10.1136/jmedgenet-2016-103839Test
https://research.manchester.ac.uk/en/publications/b545a7d4-850d-4099-960a-7b6e321e0daaTest

المؤلفون: Näslund-Koch, Charlotte, Nordestgaard, Børge G, Bojesen, Stig E

المصدر: Näslund-Koch , C , Nordestgaard , B G & Bojesen , S E 2016 , ' Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2* 1100delC Heterozygotes Estimated From the Copenhagen General Population Study ' , Journal of Clinical Oncology , vol. 34 , no. 11 , pp. 1208-16 . https://doi.org/10.1200/JCO.2015.63.3594Test

مصطلحات موضوعية: Aged, Breast Neoplasms, Checkpoint Kinase 2, Denmark, Female, Genetic Predisposition to Disease, Genotype, Germ-Line Mutation, Heterozygote, Humans, Incidence, Kaplan-Meier Estimate, Middle Aged, Neoplasms, Multiple Primary, Odds Ratio, Registries, Research Design, Risk Assessment, Risk Factors, Surveys and Questionnaires, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't

الإتاحة: https://doi.org/10.1200/JCO.2015.63.3594Test
https://curis.ku.dk/portal/da/publications/increased-risk-for-other-cancers-in-addition-to-breast-cancer-for-chek21100delc-heterozygotes-estimated-from-the-copenhagen-general-population-studyTest(1e524937-d857-4bc7-bdc9-517598c6d2e8).html

المؤلفون: Shaltiel, Indra A., Aprelia, Melinda, Saurin, Adrian T., Chowdhury, Dipanjan, Kops, Geert J. P. L., Voest, Emile E., Medema, Rene H.

المصدر: Shaltiel , I A , Aprelia , M , Saurin , A T , Chowdhury , D , Kops , G J P L , Voest , E E & Medema , R H 2014 , ' Distinct phosphatases antagonize the p53 response in different phases of the cell cycle ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 111 , no. 20 , pp. 7313-7318 . https://doi.org/10.1073/pnas.1322021111Test

مصطلحات موضوعية: Cell Cycle, Checkpoint Kinase 2, Cyclin B1, DNA, DNA Damage, Fibroblasts, G1 Phase, G2 Phase, Gene Expression Regulation, Neoplastic, Humans, Luminescent Proteins, Mutation, Phosphoprotein Phosphatases, Phosphorylation, Protein Structure, Tertiary, Retinal Pigment Epithelium, Telomerase, Tumor Suppressor Protein p53, p38 Mitogen-Activated Protein Kinases

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b0b0ed0b-67fb-4f80-8ef0-fe675648649cTest

الإتاحة: https://doi.org/10.1073/pnas.1322021111Test
https://discovery.dundee.ac.uk/en/publications/b0b0ed0b-67fb-4f80-8ef0-fe675648649cTest
https://discovery.dundee.ac.uk/ws/files/8814190/PNAS_2014_Shaltiel_7313_8.pdfTest
http://www.scopus.com/inward/record.url?scp=84901044583&partnerID=8YFLogxKTest
http://www.pnas.org/site/aboutpnas/rightperm.xhtmlTest
http://www.pnas.org/content/111/20/7313Test

المؤلفون: Muranen, Taru A, Blomqvist, Carl, Dörk, Thilo, Jakubowska, Anna, Heikkilä, Päivi, Fagerholm, Rainer, Greco, Dario, Aittomäki, Kristiina, Bojesen, Stig E, Shah, Mitul, Dunning, Alison M, Rhenius, Valerie, Hall, Per, Czene, Kamila, Brand, Judith S, Darabi, Hatef, Chang-Claude, Jenny, Rudolph, Anja, Nordestgaard, Børge G, Couch, Fergus J, Hart, Steven N, Figueroa, Jonine, García-Closas, Montserrat, Fasching, Peter A, Beckmann, Matthias W, Li, Jingmei, Liu, Jianjun, Andrulis, Irene L, Winqvist, Robert, Pylkäs, Katri, Mannermaa, Arto, Kataja, Vesa, Lindblom, Annika, Margolin, Sara, Lubinski, Jan, Dubrowinskaja, Natalia, Bolla, Manjeet K, Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Easton, Douglas F, Pharoah, Paul D P, Schmidt, Marjanka K, Nevanlinna, Heli

المصدر: Muranen , T A , Blomqvist , C , Dörk , T , Jakubowska , A , Heikkilä , P , Fagerholm , R , Greco , D , Aittomäki , K , Bojesen , S E , Shah , M , Dunning , A M , Rhenius , V , Hall , P , Czene , K , Brand , J S , Darabi , H , Chang-Claude , J , Rudolph , A , Nordestgaard , B G , Couch , F J , Hart , S N , Figueroa , J , García-Closas , M , ....

مصطلحات موضوعية: Amino Acid Substitution, Biomarkers, Tumor, Breast Neoplasms, Checkpoint Kinase 2, Cluster Analysis, Codon, Europe, Female, Gene Expression Profiling, Genetic Association Studies, Heterozygote, Humans, Mutation, Missense, Neoplasm Grading, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Transcriptome, Journal Article, Research Support, N.I.H., Extramural, Non-U.S. Gov't, U.S. Gov't, Non-P.H.S

العلاقة: https://research-information.bris.ac.uk/en/publications/b8d2586d-5e32-44ec-9316-af94a9d35ac1Test

الإتاحة: https://doi.org/10.1186/s13058-016-0758-5Test
https://hdl.handle.net/1983/b8d2586d-5e32-44ec-9316-af94a9d35ac1Test
https://research-information.bris.ac.uk/en/publications/b8d2586d-5e32-44ec-9316-af94a9d35ac1Test

المؤلفون: Lawrenson, Kate, Iversen, Edwin S, Tyrer, Jonathan, Weber, Rachel Palmieri, Concannon, Patrick, Hazelett, Dennis J, Li, Qiyuan, Marks, Jeffrey R, Berchuck, Andrew, Lee, Janet M, Aben, Katja K H, Anton-Culver, Hoda, Antonenkova, Natalia, Bandera, Elisa V, Bean, Yukie, Beckmann, Matthias W, Bisogna, Maria, Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A, Brooks-Wilson, Angela, Bruinsma, Fiona, Butzow, Ralf, Campbell, Ian G, Carty, Karen, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Chen, Ann, Chen, Zhihua, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Cybulski, Cezary, Plisiecka-Halasa, Joanna, Dennis, Joe, Dicks, Ed, Doherty, Jennifer A, Dörk, Thilo, du Bois, Andreas, Eccles, Diana, Easton, Douglas T, Edwards, Robert P, Eilber, Ursula, Ekici, Arif B, Fasching, Peter A, Fridley, Brooke L, Gao, Yu-Tang, Gentry-Maharaj, Aleksandra, Hogdall, Claus, Kjaer, Susanne Kruger

المصدر: Lawrenson , K , Iversen , E S , Tyrer , J , Weber , R P , Concannon , P , Hazelett , D J , Li , Q , Marks , J R , Berchuck , A , Lee , J M , Aben , K K H , Anton-Culver , H , Antonenkova , N , Bandera , E V , Bean , Y , Beckmann , M W , Bisogna , M , Bjorge , L , Bogdanova , N , Brinton , L A , Brooks-Wilson , A , Bruinsma , F , Butzow ....

مصطلحات موضوعية: Case-Control Studies, Checkpoint Kinase 2, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors

الإتاحة: https://doi.org/10.1093/carcin/bgv138Test
https://curis.ku.dk/portal/da/publications/common-variants-at-the-chek2-gene-locus-and-risk-of-epithelial-ovarian-cancerTest(29451e19-d612-4712-9c64-bca957e564bd).html

المؤلفون: Bilde, Anders, von Buchwald, Christian, Dabelsteen, Erik, Therkildsen, Marianne Hamilton, Dabelsteen, Sally

المصدر: Bilde , A , von Buchwald , C , Dabelsteen , E , Therkildsen , M H & Dabelsteen , S 2009 , ' Molecular markers in the surgical margin of oral carcinomas ' , Journal of Oral Pathology & Medicine , vol. 38 , no. 1 , pp. 72-8 . https://doi.org/10.1111/j.1600-0714.2008.00715.xTest

مصطلحات موضوعية: Adult, Aged, Basement Membrane, Carcinoma, Squamous Cell, Cell Adhesion Molecules, Cell Aging, Cell Nucleus, Cell Transformation, Neoplastic, Checkpoint Kinase 2, Cyclin-Dependent Kinase Inhibitor p16, Cytoplasm, DNA Replication, Epithelium, Female, Fibronectins, Humans, Immunohistochemistry, Male, Middle Aged, Mouth Mucosa, Mouth Neoplasms, Neoplasm Invasiveness, Neoplasm Staging, Protein-Serine-Threonine Kinases, Stromal Cells, Tumor Markers, Biological, Tumor Suppressor Protein p14ARF

الإتاحة: https://doi.org/10.1111/j.1600-0714.2008.00715.xTest
https://curis.ku.dk/portal/da/publications/molecular-markers-in-the-surgical-margin-of-oral-carcinomasTest(d0554fff-639d-4c31-91a8-272b00fc5f65).html

المؤلفون: Rickmyre, Jamie L, Dasgupta, Shamik, Ooi, Danny Liang-Yee, Keel, Jessica, Lee, Ethan, Kirschner, Marc W, Waddell, Scott, Lee, Laura A

المصدر: Rickmyre , J L , Dasgupta , S , Ooi , D L-Y , Keel , J , Lee , E , Kirschner , M W , Waddell , S & Lee , L A 2007 , ' The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo ' , Journal of Cell Science , vol. 120 , no. Pt 20 , pp. 3565-77 . https://doi.org/10.1242/jcs.016626Test

مصطلحات موضوعية: Animals, Cell Cycle, Cell Cycle Proteins/genetics, Checkpoint Kinase 1, Checkpoint Kinase 2, Chromatin/metabolism, Drosophila Proteins/genetics, Drosophila melanogaster/cytology, Embryo, Nonmammalian/cytology, Genes, Insect, Genomic Instability, Mitosis, Mushroom Bodies/cytology, Mutation, Protein Kinases/metabolism, Protein-Serine-Threonine Kinases/genetics

الإتاحة: https://doi.org/10.1242/jcs.016626Test
https://hdl.handle.net/1983/08d34b61-42ec-4af1-8d81-de848293374dTest
https://research-information.bris.ac.uk/en/publications/08d34b61-42ec-4af1-8d81-de848293374dTest

المؤلفون: Bartkova, Jirina, Horejsí, Zuzana, Koed, Karen, Krämer, Alwin, Tort, Frederic, Zieger, Karsten, Guldberg, Per, Sehested, Maxwell, Nesland, Jahn M, Lukas, Claudia, Ørntoft, Torben, Lukas, Jiri, Bartek, Jiri

المصدر: Bartkova , J , Horejsí , Z , Koed , K , Krämer , A , Tort , F , Zieger , K , Guldberg , P , Sehested , M , Nesland , J M , Lukas , C , Ørntoft , T , Lukas , J & Bartek , J 2005 , ' DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis ' , Nature , vol. 434 , no. 7035 , pp. 864-70 . https://doi.org/10.1038/nature03482Test

مصطلحات موضوعية: Allelic Imbalance/genetics, Cell Cycle, Cell Cycle Proteins/genetics, Cell Line, Tumor, Cell Transformation, Neoplastic/genetics, Checkpoint Kinase 2, Cyclin E/genetics, DNA Damage/genetics, DNA-Binding Proteins/genetics, E2F Transcription Factors, Enzyme Activation, Genes, p53/genetics, Genomic Instability, Humans, Mutation/genetics, Neoplasms/enzymology, Oncogenes/genetics, Phosphorylation, Polymorphism, Single Nucleotide/genetics, Protein-Serine-Threonine Kinases/metabolism, Signal Transduction, Transcription Factors/genetics, Urinary Bladder Neoplasms/enzymology, cdc25 Phosphatases/genetics

الإتاحة: https://doi.org/10.1038/nature03482Test
https://curis.ku.dk/portal/da/publications/dna-damage-response-as-a-candidate-anticancer-barrier-in-early-human-tumorigenesisTest(0e454ad1-4c14-4f67-8d60-192386f5b6fd).html

المؤلفون: Lomonosov, Mikhail, Anand, Shubha, Sangrithi, Mahesh, Davies, Rachel, Venkitaraman, Ashok R

المصدر: Lomonosov , M , Anand , S , Sangrithi , M , Davies , R & Venkitaraman , A R 2003 , ' Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein ' , Genes & Development , vol. 17 , no. 24 , pp. 3017-22 . https://doi.org/10.1101/gad.279003Test

مصطلحات موضوعية: Animals, BRCA2 Protein/physiology, Breast Neoplasms/genetics, Cell Cycle/physiology, Cells, Cultured, Checkpoint Kinase 2, DNA/chemistry, DNA Damage, DNA Repair/genetics, DNA Replication, Disease Susceptibility, Electrophoresis, Gel, Two-Dimensional, Enzyme Inhibitors/pharmacology, Female, Fibroblasts/metabolism, Hydroxyurea/pharmacology, Mice, Knockout, Phosphorylation, Protein-Serine-Threonine Kinases/metabolism, Replication Origin

العلاقة: https://research-portal.st-andrews.ac.uk/en/researchoutput/stabilization-of-stalled-dna-replication-forks-by-the-brca2-breast-cancer-susceptibility-proteinTest(7d104d1c-75db-4c44-bb18-f39a623b7c08).html

الإتاحة: https://doi.org/10.1101/gad.279003Test
https://research-portal.st-andrews.ac.uk/en/researchoutput/stabilization-of-stalled-dna-replication-forks-by-the-brca2-breast-cancer-susceptibility-proteinTest(7d104d1c-75db-4c44-bb18-f39a623b7c08).html

المؤلفون: Lomonosov, Mikhail, Anand, Shubha, Sangrithi, Mahesh, Davies, Rachel, Venkitaraman, Ashok R

المصدر: Lomonosov , M , Anand , S , Sangrithi , M , Davies , R & Venkitaraman , A R 2003 , ' Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein ' , Genes & Development , vol. 17 , no. 24 , pp. 3017-22 . https://doi.org/10.1101/gad.279003Test

مصطلحات موضوعية: Animals, BRCA2 Protein/physiology, Breast Neoplasms/genetics, Cell Cycle/physiology, Cells, Cultured, Checkpoint Kinase 2, DNA/chemistry, DNA Damage, DNA Repair/genetics, DNA Replication, Disease Susceptibility, Electrophoresis, Gel, Two-Dimensional, Enzyme Inhibitors/pharmacology, Female, Fibroblasts/metabolism, Hydroxyurea/pharmacology, Mice, Knockout, Phosphorylation, Protein-Serine-Threonine Kinases/metabolism, Replication Origin

الإتاحة: https://doi.org/10.1101/gad.279003Test
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/stabilization-of-stalled-dna-replication-forks-by-the-brca2-breast-cancer-susceptibility-proteinTest(7d104d1c-75db-4c44-bb18-f39a623b7c08).html