المؤلفون: Schütz-Fuhrmann, Ingrid, Rami-Merhar, Birgit, Fröhlich-Reiterer, Elke, Hofer, Sabine E, Tauschmann, Martin, Mader, Julia K, Resl, Michael, Kautzky-Willer, Alexandra, Winhofer-Stöckl, Yvonne, Laimer, Markus, Zlamal-Fortunat, Sandra, Weitgasser, Raimund

المصدر: Schütz-Fuhrmann, Ingrid; Rami-Merhar, Birgit; Fröhlich-Reiterer, Elke; Hofer, Sabine E; Tauschmann, Martin; Mader, Julia K; Resl, Michael; Kautzky-Willer, Alexandra; Winhofer-Stöckl, Yvonne; Laimer, Markus; Zlamal-Fortunat, Sandra; Weitgasser, Raimund (2023). [Insulin pump therapy and continuous glucose monitoring]. Wiener klinische Wochenschrift, 135(Suppl 1), pp. 53-61. Springer-Verlag 10.1007/s00508-023-02165-9 <http://dx.doi.org/10.1007/s00508-023-02165-9Test>

مصطلحات موضوعية: 610 Medicine & health, 610 Medizin und Gesundheit

الوصف: This Guideline represents the recommendations of the Austrian Diabetes Association (ÖDG) on the use of diabetes technology (insulin pump therapy; continuous glucose monitoring, CGM; hybrid closed-loop systems, HCL; diabetes apps) and access to these technological innovations for people with diabetes mellitus based on current scientific evidence.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294dec3193f1e63f93a6465a225d027dTest
https://boris.unibe.ch/182012/1/s00508-023-02165-9.pdfTest

المؤلفون: Alwan, Heba, Ware, Julia, Boughton, Charlotte K, Wilinska, Malgorzata E, Allen, Janet M, Lakshman, Rama, Nwokolo, Munachiso, Hartnell, Sara, Bally, Lia, De Beaufort, Carine, Besser, Rachel EJ, Campbell, Fiona M, Davis, Nikki, Denvir, Louise, Evans, Mark L, Fröhlich-Reiterer, Elke, Ghatak, Atrayee, Hofer, Sabine E, Kapellen, Thomas M, Leelarathna, Lalantha, Mader, Julia K, Narendran, Parth, Rami-Mehrar, Birgit, Tauschmann, Martin, Thabit, Hood, Thankamony, Ajay, Hovorka, Roman

المساهمون: Alwan, Heba [0000-0001-5516-6022], Ware, Julia [0000-0002-4497-0979], Boughton, Charlotte K [0000-0003-3272-9544], Lakshman, Rama [0000-0002-4341-1307], Bally, Lia [0000-0003-1993-7672], Besser, Rachel EJ [0000-0002-4645-6324], Mader, Julia K [0000-0001-7854-4233], Apollo - University of Cambridge Repository

المصدر: Alwan, Heba; Ware, Julia; Boughton, Charlotte K; Wilinska, Malgorzata; Allen, Janet M; Lakshman, Rama; Nwokolo, Munachiso; Hartnell, Sara; Bally, Lia; de Beaufort, Carine; Besser, Rachel Elizabeth Jane; Campbell, Fiona; Davis, Nikki; Denver, Louise; Evants, Mark L; Fröhlich-Reiterer, Elke; Ghatak, Atrayee; Hofer, Sabine E; Kapellen, Thomas M; Leelarathna, Lalantha; ... (2023). Time spent in hypoglycemia according to age and time-of-day: Observations during closed-loop insulin delivery. Diabetes technology & therapeutics, 25(7), pp. 485-491. Mary Ann Liebert 10.1089/dia.2023.0061 <http://dx.doi.org/10.1089/dia.2023.0061Test>

مصطلحات موضوعية: Adult, Blood Glucose, Adolescent, Endocrinology, Diabetes and Metabolism, Artificial pancreas, 610 Medicine & health, Young Adult, Insulin pump therapy, Endocrinology, Insulin Infusion Systems, 360 Social problems & social services, Insulin, Regular, Human, Humans, Insulin, Hypoglycemic Agents, Closed-loop insulin delivery, Child, Aged, Retrospective Studies, Cross-Over Studies, Middle Aged, Hypoglycemia, Medical Laboratory Technology, Type 1 diabetes, Diabetes Mellitus, Type 1, Treatment Outcome, Child, Preschool, Randomized trial

الوصف: Objective: We aimed to assess whether percentage of time spent in hypoglycemia during closed-loop insulin delivery differs by age group and time of day. Methods: We retrospectively analyzed data from hybrid closed-loop studies involving young children (2-7 years), children and adolescents (8-18 years), adults (19-59 years), and older adults (≥60 years) with type 1 diabetes. Main outcome was time spent in hypoglycemia

وصف الملف: application/pdf; application/msword

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665cf80fd5b3ea682b7b5b1871053e76Test

المؤلفون: Hood, Korey K, Garcia-Willingham, Natasha, Hanes, Sarah, Tanenbaum, Molly L, Ware, Julia, Boughton, Charlotte K, Allen, Janet M, Wilinska, Malgorzata E, Tauschmann, Martin, Denvir, Louise, Thankamony, Ajay, Campbell, Fiona, Wadwa, R Paul, Buckingham, Bruce A, Davis, Nikki, DiMeglio, Linda A, Mauras, Nelly, Besser, Rachel EJ, Ghatak, Atrayee, Weinzimer, Stuart A, Fox, D Steven, Kanapka, Lauren, Kollman, Craig, Sibayan, Judy, Beck, Roy W, Hovorka, Roman, DAN05 Consortium

المساهمون: Hood, Korey K [0000-0001-5730-7749], Boughton, Charlotte K [0000-0003-3272-9544], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Blood Glucose, Parents, Diabetes Mellitus, Type 1, Treatment Outcome, Insulin Infusion Systems, Adolescent, Blood Glucose Self-Monitoring, Quality of Life, Humans, Insulin, Hypoglycemic Agents, Child

الوصف: AIM: To examine changes in the lived experience of type 1 diabetes after use of hybrid closed loop (CL), including the CamAPS FX CL system. MATERIALS AND METHODS: The primary study was conducted as an open-label, single-period, randomized, parallel design contrasting CL versus insulin pump (with or without continuous glucose monitoring). Participants were asked to complete patient-reported outcomes before starting CL and 3 and 6 months later. Surveys assessed diabetes distress, hypoglycaemia concerns and quality of life. Qualitative focus group data were collected at the completion of the study. RESULTS: In this sample of 98 youth (age range 6-18, mean age 12.7 ± 2.8 years) and their parents, CL use was not associated with psychosocial benefits overall. However, the subgroup (n = 12) using the CamAPS FX system showed modest improvements in quality of life and parent distress, reinforced by both survey (p < .05) and focus group responses. There were no negative effects of CL use reported by study participants. CONCLUSIONS: Closed loop use via the CamAPS FX system was associated with modest improvements in aspects of the lived experience of managing type 1 diabetes in youth and their families. Further refinements of the system may optimize the user experience.

وصف الملف: application/pdf; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33d752d25f167dc45d9af12213c2d09Test

المؤلفون: Ware, Julia, Allen, Janet M, Boughton, Charlotte K, Wilinska, Malgorzata E, Hartnell, Sara, Thankamony, Ajay, Carine de Beaufort, Carine, Schierloh, Ulrike, Froehlich- Reiterer, Elke, Mader, Julia K, Kapellen, Thomas M, Rami-Merhar, Birgit, Tauschmann, Martin, Nagl, Katrin, Hofer, Sabine E, Campbell, Fiona, Yong, James, Hood, Korey, Lawton, Julia, Roze, Stephane, Sibayan, Judy, Bocchino, Laura, Kollman, Craig, Hovorka, Roman

المصدر: Ware, J, Allen, J M, Boughton, C K, Wilinska, M E, Hartnell, S, Thankamony, A, Carine de Beaufort, C, Schierloh, U, Froehlich-Reiterer, E, Mader, J K, Kapellen, T M, Rami-Merhar, B, Tauschmann, M, Nagl, K, Hofer, S E, Campbell, F, Yong, J, Hood, K, Lawton, J, Roze, S, Sibayan, J, Bocchino, L, Kollman, C & Hovorka, R 2022, ' A Randomized Closed-loop Trial in Very Young Children with Type 1 Diabetes ', New England Journal of Medicine, vol. 386, no. 3, pp. 209-219 . https://doi.org/10.1056/NEJMoa2111673Test

الوصف: BACKGROUND The possible advantage of hybrid closed-loop therapy (i.e., artificial pancreas) over sensor-augmented pump therapy in very young children with type 1 diabetes is unclear. METHODS In this multicenter, randomized, crossover trial, we recruited children 1 to 7 years of age with type 1 diabetes who were receiving insulin-pump therapy at seven centers across Austria, Germany, Luxembourg, and the United Kingdom. Participants received treatment in two 16-week periods, in random order, in which the closed-loop system was compared with sensor-augmented pump therapy (control). The primary end point was the between-treatment difference in the percentage of time that the sensor glucose measurement was in the target range (70 to 180 mg per deciliter) during each 16-week period. The analysis was conducted according to the intention-to-treat principle. Key secondary end points included the percentage of time spent in a hyperglycemic state (glucose level, >180 mg per deciliter), the glycated hemoglobin level, the mean sensor glucose level, and the percentage of time spent in a hypoglycemic state (glucose level

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______3094::2177e3c0a709e7d3965d0c292cb8f9d1Test
https://hdl.handle.net/20.500.11820/012d54a2-7396-4e27-8f6d-7ca46164194fTest

المؤلفون: Tauschmann, Martin, Schwandt, Anke, von Sengbusch, Simone, Holl, Reinhard W., Prinz, Nicole, Becker, Marianne, Biester, Torben, Hess, Melanie, Holder, Martin, Karges, Beate Maria, Näke, Andrea, Kuss, Oliver

المصدر: Pediatric diabetes 23(3), 330-340 (2022). doi:10.1111/pedi.13320

مصطلحات موضوعية: Glycated Hemoglobin, Male, Adolescent, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, Body Mass Index, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Pediatrics, Perinatology and Child Health, Internal Medicine, Humans, Hypoglycemic Agents, Insulin, Female, BMI, CSII, DPV, GBMT, TDD, children and adolescents with type 1 diabetes, diabetes, insulin pump, longitudinal patterns, multi trajectory modeling, trajectories of HbA1c, type 1 diabetes

الوصف: Pediatric diabetes 23(3), 330-340 (2022). doi:10.1111/pedi.13320
Published by Wiley-Blackwell, Oxford [u.a.]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d432473c7502a69f77f41bec31842c7Test
https://publications.rwth-aachen.de/record/889488Test

المؤلفون: De Beaufort, Carine, Pit-Ten Cate, Ineke, Schierloh, Ulrike, Cohen, Nathan, Boughton, Charlotte, Tauschmann, Martin, Allen, Janet M., Nagl, Katrin, Fritsch, Maria, Yong, James, Metcalfe, Emily, Schaeffer, Dominique, Fichelle, Muriel, Thiele, Alena G., Abt, Daniela, Faninger, Kerstin, Mader, Julia K., Slegtenhorst, Sonja, Ashcroft, Nicole, Wilinska, Malgorzata E., Sibayan, Judy, Kollman, Craig, Hofer, Sabine E., Frohlich-Reiterer, Elke, Kapellen, Thomas, Acerini, Carlo, Campbell, Fiona, Rami-Merhar, Birgit, Hovorka, Roman

المصدر: info:eu-repo/grantAgreement/EC/H2020/731560

مصطلحات موضوعية: Very young children, Endocrinology, metabolism & nutrition [D06] [Human health sciences], Type 1 Diabetes, Hypoglycemia fear, child behavior, sleepiness, Parental well-being, Endocrinologie, métabolisme & nutrition [D06] [Sciences de la santé humaine]

الوصف: Background: Type 1 diabetes in young children is a heavy parental burden. As part of pilot phase of the KIDSAP01 study, we conducted a baseline assessment in parents to study the association between hypoglycemia fear, parental wellbeing and child behavior. Methods: All parents were invited to fill in baseline questionnaires: hypoglycemia fear survey (HFS), WHO-5, Epworth Sleepiness Scale and Strength and Difficulties Questionnaire (SDQ). Results: 24 children (median age: 5-year, range 1-7 years, 63% male, mean diabetes duration: 3 ± 1.7 years) participated. 23/24 parents filled out the questionnaires. We found a higher score for the hypoglycemia fear behavior 33.9 ± 5.6 compared to hypoglycemia worry 34.6 ± 12.2. Median WHO-5 score was 16 (8 - 22) with poor well-being in two parents. Median daytime sleepiness score was high in five parents (>10). For six children a high total behavioral difficulty score (>16) was reported. Pro social behavior score was lower than normal in six children (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______2658::0ef5a06763e2ac7f7d72d1b72dcd0301Test
http://orbilu.uni.lu/handle/10993/47811Test

المؤلفون: KidsAP Consortium, Fuchs, Julia, Allen, Janet M, Boughton, Charlotte K, Wilinska, Malgorzata E, Thankamony, Ajay, de Beaufort, Carine, Campbell, Fiona, Yong, James, Fröhlich-Reiterer, Elke, Mader, Julia K, Hofer, Sabine E, Kapellen, Thomas M, Rami-Merhar, Birgit, Tauschmann, Martin, Hood, Korey, Kimbell, Barbara, Lawton, Julia, Roze, Stephane, Sibayan, Judy, Cohen, Nathan, Hovorka, Roman, Schierloh, Ulrike

المساهمون: Fuchs, Julia [0000-0002-4497-0979], Boughton, Charlotte K [0000-0003-3272-9544], Apollo - University of Cambridge Repository, Clinical sciences

المصدر: BMJ Open
2021, ' Assessing the efficacy, safety and utility of closed-loop insulin delivery compared to sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study) : an open-label, multi-centre, multi-national, randomised crossover study protocol ', BMJ Open . https://doi.org/10.1136/bmjopen-2020-042790Test

مصطلحات موضوعية: Insulin pump, Blood Glucose, medicine.medical_specialty, Luxembourg, Diabetes Mellitus, Type 1/drug therapy, diabetes & endocrinology, Hypoglycemic Agents/therapeutic use, 030209 endocrinology & metabolism, paediatrics, 03 medical and health sciences, 0302 clinical medicine, Insulin Infusion Systems, Quality of life, Diabetes management, medicine, Clinical endpoint, Humans, Hypoglycemic Agents, Insulin, Multicenter Studies as Topic, 030212 general & internal medicine, Child, Randomized Controlled Trials as Topic, Protocol (science), Research ethics, Type 1 diabetes, Cross-Over Studies, business.industry, general diabetes, Blood Glucose Self-Monitoring, Infant, General Medicine, medicine.disease, Crossover study, 3. Good health, Diabetes and Endocrinology, Diabetes Mellitus, Type 1, Treatment Outcome, Insulin/therapeutic use, Austria, Child, Preschool, Physical therapy, Quality of Life, business, paediatric endocrinology

الوصف: IntroductionDiabetes management in very young children remains challenging. Glycaemic targets are achieved at the expense of high parental diabetes management burden and frequent hypoglycaemia, impacting quality of life for the whole family. Our objective is to assess whether automated insulin delivery can improve glycaemic control and alleviate the burden of diabetes management in this particular age group.Methods and analysisThe study adopts an open-label, multinational, multicentre, randomised, crossover design and aims to randomise 72 children aged 1–7 years with type 1 diabetes on insulin pump therapy. Following screening, participants will receive training on study insulin pump and study continuous glucose monitoring devices. Participants will be randomised to 16-week use of the hybrid closed-loop system (intervention period) or to 16-week use of sensor-augmented pump therapy (control period) with 1–4 weeks washout period before crossing over to the other arm. The order of the two study periods will be random. The primary endpoint is the between-group difference in time spent in the target glucose range from 3.9 to 10.0 mmol/L based on sensor glucose readings during the 16-week study periods. Analyses will be conducted on an intention-to-treat basis. Key secondary endpoints are between group differences in time spent above and below target glucose range, glycated haemoglobin and average sensor glucose. Participants’ and caregivers’ experiences will be evaluated using questionnaires and qualitative interviews, and sleep quality will be assessed. A health economic analysis will be performed.Ethics and disseminationEthics approval has been obtained from Cambridge East Research Ethics Committee (UK), Ethics Committees of the University of Innsbruck, the University of Vienna and the University of Graz (Austria), Ethics Committee of the Medical Faculty of the University of Leipzig (Germany) and Comité National d’Ethique de Recherche (Luxembourg). The results will be disseminated by peer-reviewed publications and conference presentations.Trial registration numberNCT03784027.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2bcd942c2af450531403bce7871134Test

المؤلفون: Musolino, Gianluca, Dovc, Klemen, Boughton, Charlotte K, Tauschmann, Martin, Allen, Janet M, Nagl, Katrin, Fritsch, Maria, Yong, James, Metcalfe, Emily, Schaeffer, Dominique, Fichelle, Muriel, Schierloh, Ulrike, Thiele, Alena G, Abt, Daniela, Kojzar, Harald, Mader, Julia K, Slegtenhorst, Sonja, Ashcroft, Nicole, Wilinska, Malgorzata E, Sibayan, Judy, Cohen, Nathan, Kollman, Craig, Hofer, Sabine E, Fröhlich-Reiterer, Elke, Kapellen, Thomas M, Acerini, Carlo L, De Beaufort, Carine, Campbell, Fiona, Rami-Merhar, Birgit, Hovorka, Roman, Kidsap Consortium

المساهمون: Musolino, Gianluca [0000-0002-4313-2834], Dovc, Klemen [0000-0001-9201-2145], Nagl, Katrin [0000-0001-6489-9068], Schierloh, Ulrike [0000-0002-7644-4818], Hofer, Sabine E [0000-0001-6778-0062], Acerini, Carlo L [0000-0003-2121-5871], Rami-Merhar, Birgit [0000-0001-5575-5222], Hovorka, Roman [0000-0003-2901-461X], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Blood Glucose, Male, Parents, Cross-Over Studies, type 1 diabetes, artificial pancreas, Blood Glucose Self-Monitoring, Infant, Circadian Rhythm, very young children, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Caregivers, Cost of Illness, Child, Preschool, Surveys and Questionnaires, Quality of Life, closed-loop insulin delivery, Humans, Insulin, Family, Female, Child

الوصف: OBJECTIVE: To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day-and-night hybrid closed-loop insulin delivery. METHODS: Parents/caregivers of 20 children aged 1 to 7 years with type 1 diabetes completed a closed-loop experience survey following two 3-week periods of unrestricted day-and-night hybrid closed-loop insulin therapy using Cambridge FlorenceM system at home. Benefits, limitations, and improvements of closed-loop technology were explored. RESULTS: Responders reported reduced burden of diabetes management, less time spent managing diabetes, and improved quality of sleep with closed-loop. Ninety percent of the responders felt less worried about their child's glucose control using closed-loop. Size of study devices, battery performance and connectivity issues were identified as areas for improvement. Parents/caregivers wished for more options to input information to the system such as temporary glucose targets. CONCLUSIONS: Parents/caregivers of very young children reported important quality of life benefits associated with using closed-loop, supporting adoption of this technology in this population.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c340e47d5f378d6f422cc9ed6a8654Test
https://www.repository.cam.ac.uk/handle/1810/293236Test

المؤلفون: Ruan, Yue, Willemsen, Ruben H, Wilinska, Malgorzata E, Tauschmann, Martin, Dunger, David B, Hovorka, Roman

المساهمون: Ruan, Yue [0000-0003-3498-2543], Dunger, David B [0000-0002-2566-9304], Hovorka, Roman [0000-0003-2901-461X], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Blood Glucose, Glycated Hemoglobin, Male, Adolescent, C-Peptide, type 1 diabetes, Postprandial Period, Diagnostic Techniques, Endocrine, Diabetes Mellitus, Type 1, mixed-meal tolerance test, Area Under Curve, Insulin-Secreting Cells, Insulin Secretion, Feasibility Studies, Humans, Female, beta-cell secretion, Child, Meals

الوصف: AIMS: Residual beta-cell secretion in type 1 diabetes is commonly assessed by area-under-curve of plasma C-peptide concentration (AUCCpep ) following mixed-meal tolerance test (MMTT). We aimed to investigate alternative measures of beta-cell responsiveness. METHODS: We analyzed data from 32 youth (age 7 to 17 years) undergoing MMTT within 6 months of type 1 diabetes diagnosis. We related AUCCpep with (a) validated mechanistic index of postprandial beta-cell responsiveness MI accounting for glucose level during MMTT, and (b) pragmatic marker calculated as baseline plasma C-peptide concentration corrected for baseline plasma glucose concentration. RESULTS: Postprandial responsiveness MI was correlated with age and BMI SDS (Rs = 0.66 and 0.44, P < 0.01 and P < 0.05) and was more correlated with glycated hemoglobin than AUCCpep (Rs = 0.79, P = 0.04). The pragmatic marker was highly correlated with AUCCpep (Rs = 0.94, P < 0.01). CONCLUSIONS: Postprandial responsiveness MI may be more relevant to glucose control than AUCCpep . Baseline C-peptide corrected for baseline glucose appears to be a suitable surrogate of AUCCpep if MMTT is not performed.

وصف الملف: application/msword

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6b3ad4ea484a957fb16e0fab543ee3Test
https://www.repository.cam.ac.uk/handle/1810/288800Test

المؤلفون: Dovc, Klemen, Boughton, Charlotte, Tauschmann, Martin, Thabit, Hood, Bally, Lia, Allen, Janet M, Acerini, Carlo L, Arnolds, Sabine, De Beaufort, Carine, Bergenstal, Richard M, Campbell, Fiona, Criego, Amy, Dunger, David B, Elleri, Daniella, Evans, Mark L, Fröhlich-Reiterer, Elke, Hofer, Sabine, Kapellen, Thomas, Leelarathna, Lalantha, Pieber, Thomas R, Rami-Merhar, Birgit, Shah, Viral N, Sibayan, Judy, Wilinska, Malgorzata E, Hovorka, Roman, APCam11, AP@Home

المساهمون: Bally, Lia [0000-0003-1993-7672], Bergenstal, Richard M [0000-0002-9050-5584], Campbell, Fiona [0000-0002-7618-6759], Dunger, David B [0000-0002-2566-9304], Leelarathna, Lalantha [0000-0001-9602-1962], Shah, Viral N [0000-0002-3827-7107], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Adult, Blood Glucose, Male, Cross-Over Studies, Adolescent, Dose-Response Relationship, Drug, Blood Glucose Self-Monitoring, Age Factors, Individuality, Infant, Middle Aged, Young Adult, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Child, Preschool, Humans, Hypoglycemic Agents, Insulin, Multicenter Studies as Topic, Female, Child, Aged, Randomized Controlled Trials as Topic, Retrospective Studies

الوصف: OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, n = 20), children (7-12 years, n = 21), adolescents (13-17 years, n = 15), and adults (>18 years, n = 58) with type 1 diabetes. The coefficient of variation quantified variability of insulin needs during 3 weeks of unrestricted-living hybrid closed-loop use. RESULTS: Data from 2,365 nights and 2,367 days in 114 participants were analyzed. The coefficient of variation of insulin delivery was higher in young children compared with adults (mean difference at nighttime 10.7 percentage points [95% CI 2.9-18.4], P = 0.003; daytime 6.4 percentage points [95% CI 2.0-10.9], P = 0.002) and compared with adolescents (mean difference at nighttime 10.2 percentage points [95% CI 0.0-20.4], P = 0.049; daytime 7.0 percentage points [95% CI 1.1-12.8], P = 0.014). CONCLUSIONS: Diabetes management in young children is complicated by higher variability in insulin requirements, supporting fast-track clinical practice adoption of closed-loop in this vulnerable population.

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c530b3756203ddef6fb242288c84ecTest