-
1Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes
المؤلفون: Clare Megson, Anna E. Long, Isabel V. Wilson, F. Susan Wong, Rachel J Aitken, Stephanie J. Hanna, Kathleen M Gillespie, Joanne Boldison
المصدر: Diabetologia
Boldison, J, Long, A E, Aitken, R J, Wilson, I V, Hanna, S, Wong, F S & Gillespie, K M 2022, ' Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes ', Diabetologia, vol. 65, no. 2, pp. 343-355 . https://doi.org/10.1007/s00125-021-05595-0Testمصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, autoantibodies, Endocrinology, Diabetes and Metabolism, T cell, Peripheral blood mononuclear cell, T-Lymphocytes, Regulatory, regulatory T cells, Article, Flow cytometry, Memory T Cells, Diabetes mellitus, Glucocorticoid-Induced TNFR-Related Protein, Internal Medicine, medicine, Humans, CD134, IL-2 receptor, Lymphocyte Count, Autoantibodies, Aged, Type 1 diabetes, medicine.diagnostic_test, business.industry, Autoantibody, Regulatory T cells, Middle Aged, medicine.disease, Flow Cytometry, CD4+ T cells, Slow progression, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Immunology, Female, business, Follow-Up Studies
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460b8482e2433313b173be3da48524a8Test
http://europepmc.org/articles/PMC8741669Test -
2
المؤلفون: Martin Haupt-Jorgensen, Karsten Buschard, Flemming Pociot, Kristina Pedersen, Knut Dahl-Jørgensen, Ivan C. Gerling, Simranjeet Kaur, Lars Krogvold
المصدر: Diabetologia
Pedersen, K, Haupt-Jorgensen, M, Krogvold, L, Kaur, S, Gerling, I C, Pociot, F, Dahl-Jørgensen, K & Buschard, K 2021, ' Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes : potential contribution to dysregulation of innate antiviral immunity ', Diabetologia, vol. 64, no. 8, pp. 1805-1815 . https://doi.org/10.1007/s00125-021-05469-5Testمصطلحات موضوعية: Adult, Male, 0301 basic medicine, Ribonuclease L, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Disease, Type 2 diabetes, Biology, Interferon α, RNase L, Type 1 interferon, Antiviral Agents, Polymorphism, Single Nucleotide, Article, Virus, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal Medicine, Genetic predisposition, medicine, Humans, Genetic Predisposition to Disease, RNA, Messenger, Gene, Type 1 diabetes, Oligoribonucleotides, Adenine Nucleotides, RNA-Binding Proteins, medicine.disease, Immunity, Innate, Toll-like receptor 7, Diabetes Mellitus, Type 1, 030104 developmental biology, Gene Expression Regulation, Virus Diseases, Immunology, 2′-5′A pathway, 2′-5′ Oligoadenylate synthetase, Female, Genome-Wide Association Study
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7c11e2de9bab5e6655271157f4e1c3Test
https://doi.org/10.1007/s00125-021-05469-5Test -
3
المؤلفون: Carmella Evans-Molina, Clive Wasserfall, Megan T Legge, Eleni Beli, Craig A. Beam, Ryan Silk, Kieran M. Mcgrail, Linda A. DiMeglio, Mark A. Atkinson, Stephanie Woerner, Maria B. Grant
المصدر: Diabetologia
Beam, C A, Beli, E, Wasserfall, C H, Woerner, S E, Legge, M T, Evans-Molina, C, McGrail, K M, Silk, R, Grant, M B, Atkinson, M A & DiMeglio, L A 2021, ' Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes ', Diabetologia . https://doi.org/10.1007/s00125-021-05468-6Testمصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Circadian clock, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Mice, 0302 clinical medicine, Cytotoxic T cell, education.field_of_study, B-Lymphocytes, Immune cells, Flow Cytometry, Circadian Rhythm, Cytokine, Type 1 diabetes, Female, Adult, Adolescent, Period (gene), Population, Biology, Chronobiology Disorders, circadian ryhtms, Article, 03 medical and health sciences, Clinical, Young Adult, Immune system, SDG 3 - Good Health and Well-being, Circadian Clocks, Internal Medicine, medicine, Animals, Humans, Circadian rhythms, Circadian rhythm, Lymphocyte Count, education, Interleukin-6, Dendritic Cells, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Diabetes Mellitus, Type 1, Immune System, Immunology, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304384a2a7eb86434e13bd1acc63ddbTest
http://europepmc.org/articles/PMC8245361Test -
4
المؤلفون: Heikki Hyöty, Santosh Lamichhane, Jorma Ilonen, Partho Sen, Jorma Toppari, Tuomas Lindeman, Matej Orešič, Esko Kemppainen, Riitta Veijola, María Asunción López-Bascón, Tuukka Rönkkö, Mikael Knip, Tuulia Hyötyläinen, Alex M. Dickens
المساهمون: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University, HUS Children and Adolescents, Children's Hospital, Research Programs Unit, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine
المصدر: Diabetologia
مصطلحات موضوعية: Male, 0301 basic medicine, PREDICTION, Endocrinology, Diabetes and Metabolism, CHILDHOOD, Autoimmunity, ACTIVATION, Transcriptome, 0302 clinical medicine, Longitudinal Studies, RISK, Aged, 80 and over, Sisätaudit - Internal medicine, Middle Aged, 3. Good health, Type 1 diabetes, Disease Progression, Female, Birth cohort, Adult, FEASIBILITY, Genotype, 030209 endocrinology & metabolism, Ceramides, Peripheral blood mononuclear cell, Article, Islets of Langerhans, Young Adult, 03 medical and health sciences, Metabolomics, Immune system, INFLAMMATION, Lipidomics, Internal Medicine, medicine, Humans, Aged, Autoantibodies, Sphingolipids, business.industry, Sphingolipid metabolism, Autoantibody, Lipid metabolism, Lipid Metabolism, medicine.disease, MICROBIOME, Diabetes Mellitus, Type 1, 030104 developmental biology, Genome-scale metabolic modelling, Peripheral blood mononuclear cells, ANTIBODIES, Immunology, Leukocytes, Mononuclear, 3111 Biomedicine, ISLET AUTOANTIBODIES, business
وصف الملف: application/pdf; fulltext; 1017–1031
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8db141e75e5dead62b6ef2f2c63a3dTest
https://doi.org/10.1007/s00125-020-05107-6Test -
5
المؤلفون: Vittorio Krogh, Rudolf Kaaks, Yvonne T. van der Schouw, Gianluca Severi, Eva Ardanaz, Marc J. Gunter, Tilman Kühn, Nicholas J. Wareham, Timothy J. Key, Francesca Mancini, Carlotta Sacerdote, María José Sánchez, Heiner Boeing, Annemieke M.W. Spijkerman, Peter M. Nilsson, Guy Fagherazzi, Miren Dorronsoro, María Dolores Chirlaque, Kay-Tee Khaw, Olov Rolandsson, Stephen J. Sharp, Salvatore Panico, Domenico Palli, Nita G. Forouhi, Christiane S. Hampe, Claudia Langenberg, Kim Overvad, Rosario Tumino, Elio Riboli
المساهمون: Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), LSHM_CT_2006_037197 N∫ 6236 National Institutes of Health, NIH: DK26190 Compagnia di San Paolo Kræftens Bekæmpelse, DCS German Cancer Research Center, DKFZ Medical Research Council, MRC: MC_UU_12015/1, MC_UU_12015/5, MR/N003284/1 Cancer Research UK, CRUK World Cancer Research Fund, WCRF Bundesministerium für Bildung und Forschung, BMBF Västerbotten Läns Landsting Ministerie van Volksgezondheid, Welzijn en Sport, VWS Agentschap NL: IGE05012 Vetenskapsrådet, VR Umeå Universitet Bundesministerium für Forschung und Technologie, BMFT Deutsche Krebshilfe Bundesministerium für Bildung und Frauen, BMBF Stichting Diabetes Onderzoek Nederland NIHR Imperial Biomedical Research Centre, BRC NIHR Cambridge Biomedical Research Centre: IS-BRC-1215-20014, O. Rolandsson: The Västerboten County Council, M. Dorronsoro: We thank the participants of the Spanish EPIC cohort for their contribution to the study as well as to the team of trained nurses who participated in the recruitment, R. Kaaks: German Cancer Aid, German Ministry of Research (BMBF), K. T. Khaw: Medical Research Council UK, Cancer Research UK, T. Kühn: German Cancer Aid, German Cancer Research Center (DKFZ), German Federal Ministry of Education and Research (BMBF), S. Panico: Compagnia di San Paolo, A. M. W. Spijkerman: EPIC Bilthoven and Utrecht acknowledge the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), Statistics Netherlands (the Netherlands), EPIC Ragusa acknowledges for their participation blood donors of AVIS-Ragusa (local blood donors association), Y. T. van der Schouw: EPIC Bilthoven and Utrecht acknowledge the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), Dutch ZON (Zorg Onderzoek Nederland), WCRF, Statistics Netherland, E. Riboli: Imperial College Biomedical Research Centre., Open access funding provided by Umea University. Funding for the InterAct project was provided by the EU FP6 Programme (grant number LSHM_CT_2006_037197). The autoantibody measurement was funded by Västerbotten County Council and Umeå University, Sweden (OR), the National Institutes of Health (DK26190) (CSH) and the Medical Research Council (MC_UU_12015/1) (NJW). OR: the Västerbotten County Council, Umeå University, MDC: Health Research Fund (FIS) of the Spanish Ministry of Health, Murcia Regional Government (N∫ 6236), EA: the Health Research Fund (FIS) of the Spanish Ministry of Health and Navarre Regional Government, RK: German Cancer Aid, the German Ministry of Research (BMBF), TJK: Cancer Research UK, KTK: the Medical Research Council UK, Cancer Research UK, PMN: the Swedish Research Council, KO: the Danish Cancer Society, SP: Compagnia di San Paolo, AMWS: the Dutch Ministry of Public Health, Welfare and Sports (VWS), the Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands, RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government, AMWS: LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), YTvdS: verification of diabetes cases was additionally funded by NL Agency grant IGE05012 and an Incentive Grant from the Board of the UMC Utrecht, LK Research Funds, Dutch Prevention Funds, NGF: MRC core support (MC_UU_12015/5), NIHR Cambridge Biomedical Research Centre (IS-BRC-1215-20014). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Acknowledgements, We thank all EPIC participants and staff for their contribution to this study. We thank N. Kerrison (MRC Epidemiology Unit, Cambridge, UK) for managing the data and the laboratory team at the MRC Epidemiology Unit, Cambridge for managing the blood samples for the EPIC-InterAct project. We thank the participants of the Spanish EPIC cohort for their contribution to the study as well as the team of trained nurses who participated in the recruitment. O. Rolandsson: The V?sterboten County Council, T. K?hn: German Cancer Aid, German Cancer Research Center (DKFZ), German Federal Ministry of Education and Research (BMBF), E. Riboli: Imperial College Biomedical Research Centre. Some of the data were presented as an abstract at the 54th EASD Annual Meeting in 2018., Rolandsson, Olov [0000-0002-1341-6828], Apollo - University of Cambridge Repository
المصدر: Rolandsson, O, Hampe, C S, Sharp, S J, Ardanaz, E, Boeing, H, Fagherazzi, G, Mancini, F R, Nilsson, P M, Overvad, K, Chirlaque, M-D, Dorronsoro, M, Gunter, M J, Kaaks, R, Key, T J, Khaw, K-T, Krogh, V, Kühn, T, Palli, D, Panico, S, Sacerdote, C, Sánchez, M-J, Severi, G, Spijkerman, A M W, Tumino, R, van der Schouw, Y T, Riboli, E, Forouhi, N G, Langenberg, C & Wareham, N J 2020, ' Autoimmunity plays a role in the onset of diabetes after 40 years of age ', Diabetologia, vol. 63, no. 2, pp. 266-277 . https://doi.org/10.1007/s00125-019-05016-3Test
Diabetologia
Diabetologia, Springer Verlag, 2020, 63 (2), pp.266-277. ⟨10.1007/s00125-019-05016-3⟩
Diabetologia, 63, 266. Springer Verlagمصطلحات موضوعية: Male, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Autoimmunity, Type 2 diabetes, medicine.disease_cause, LADA, Endocrinology, Autoantibody, 0302 clinical medicine, POPULATION, RISK, 0303 health sciences, Glutamate Decarboxylase, ANTIBODY POSITIVITY, GAD, Middle Aged, Phenotype, Genetic risk score, Pathophysiology, 3. Good health, Diabetes and Metabolism, Type 1 diabetes, Endokrinologi och diabetes, Female, Life Sciences & Biomedicine, Adult, 030209 endocrinology & metabolism, Endocrinology and Diabetes, Antibodies, Article, 1117 Public Health and Health Services, Endocrinology & Metabolism, 03 medical and health sciences, GLUTAMIC-ACID DECARBOXYLASE, Insulin resistance, Diabetes mellitus, Internal Medicine, medicine, Humans, TYPE-1, Aged, 030304 developmental biology, Science & Technology, business.industry, RECOGNITION, 1103 Clinical Sciences, ADULTS, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Incident diabetes, Case-Control Studies, Immunology, 1114 Paediatrics and Reproductive Medicine, AUTOANTIBODIES, indident diabetes, business
وصف الملف: application/pdf; text/xml; image/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46551c110c8a2c18bb7e24b7c5c12882Test
https://doi.org/10.1007/s00125-019-05016-3Test -
6
المؤلفون: Shuang Jia, Mary L. Kaldunski, Yi-Guang Chen, Carla J. Greenbaum, Martin J. Hessner, Rhonda Geoffrey, Pippa Simpson, Susanne M. Cabrera, Aniko Szabo, Samuel Engle, Cate Speake
المصدر: Diabetologia
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Therapeutic response, Adolescent, Endocrinology, Diabetes and Metabolism, Period (gene), T cell, Inflammation, Kaplan-Meier Estimate, Honeymoon, Article, Abatacept, Young Adult, 03 medical and health sciences, Partial remission, Insulin Secretion, Gene expression, Internal Medicine, medicine, Humans, Child, Gene, CTLA4-Ig, Type 1 diabetes, Innate immune system, business.industry, Biomarker, Flow Cytometry, medicine.disease, Immunity, Innate, Disease heterogeneity, 3. Good health, Diabetes Mellitus, Type 1, 030104 developmental biology, medicine.anatomical_structure, Immunology, Leukocytes, Mononuclear, Biomarker (medicine), Female, medicine.symptom, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba9afb59a0e49614e23af054dcbe267Test
https://doi.org/10.1007/s00125-018-4708-xTest -
7
المؤلفون: Reeta Rintamäki, Jorma Ilonen, Ahmad M. Gazali, Mikael Knip, Riitta Veijola, Tuure Kinnunen, Kirsti Näntö-Salonen, Anna-Mari Schroderus, Jussi Pihlajamäki, Jorma Toppari
المساهمون: Tampere University, Clinical Medicine, Department of Paediatrics, HUS Children and Adolescents, Children's Hospital, Research Programs Unit, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine
المصدر: Diabetologia
مصطلحات موضوعية: 0301 basic medicine, Male, Endocrinology, Diabetes and Metabolism, LOCI, PROGRESSION, CHILDREN, Autoimmunity, SUSCEPTIBILITY, medicine.disease_cause, 0302 clinical medicine, Immunophenotyping, Mucosal immunity, 3123 Gynaecology and paediatrics, Cells, Cultured, RISK, 318 Medical biotechnology, medicine.diagnostic_test, biology, CORRELATE, Flow Cytometry, medicine.anatomical_structure, Type 1 diabetes, Female, Human, Adult, T cell, CD3, T cells, MAIT cells, Mucosal associated invariant T cell, 3121 Internal medicine, Mucosal-Associated Invariant T Cells, Article, Flow cytometry, 03 medical and health sciences, Diabetes mellitus, Internal Medicine, medicine, Humans, business.industry, medicine.disease, TRENDS, Immunity, Innate, MICROBIOTA COMPOSITION, 030104 developmental biology, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 3121 General medicine, internal medicine and other clinical medicine, Immunology, biology.protein, Natural Killer T-Cells, business, 030215 immunology
وصف الملف: fulltext; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6eed56f74cec1b6a065454ac09a925Test
https://pubmed.ncbi.nlm.nih.gov/32880687Test -
8
المؤلفون: Alexia Carré, Etienne Larger, Roberto Mallone, Sarah J. Richardson
المصدر: Diabetologia
مصطلحات موضوعية: 0301 basic medicine, Endotype, T-Lymphocytes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Autoimmunity, Review, CD8-Positive T-Lymphocytes, medicine.disease_cause, Mice, 0302 clinical medicine, Medicine, Age of Onset, 16. Peace & justice, 3. Good health, HLA, medicine.anatomical_structure, Immunotherapy, Islets, Adult, Adolescent, T cell, T cells, 030209 endocrinology & metabolism, Human leukocyte antigen, Islets of Langerhans, Young Adult, 03 medical and health sciences, Antigen, Internal Medicine, Animals, Humans, Genetic Predisposition to Disease, Pancreas, Autoantibodies, business.industry, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Beta cells, Endotypes, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Immunology, business, Insulitis, CD8
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798c96d19de623ce065102bd09c6ebddTest
-
9
المؤلفون: Craig A. Beam, Johnny Ludvigsson, Kevan C. Herold, Colleen MacCallum, Jerry P. Palmer, Diane K. Wherrett
المصدر: Diabetologia. 60:43-49
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Bayesian probability, 030209 endocrinology & metabolism, Placebo, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, Humans, Insulin, 030212 general & internal medicine, Child, Vaccines, Type 1 diabetes, Glutamate Decarboxylase, business.industry, Bayes Theorem, Middle Aged, medicine.disease, Clinical trial, Vaccination, Diabetes Mellitus, Type 1, Meta-analysis, Immunology, Female, business, Expected loss
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c011f637d406d9cfe7e1d2407ca06478Test
https://doi.org/10.1007/s00125-016-4122Test-1 -
10
المؤلفون: Lutgart Overbergh, Hannelie Korf, Bart Vaes, Conny Gysemans, Peter Sterkendries, Chantal Mathieu, Harry Heimberg, Gunter Leuckx, João Paulo Monteiro Carvalho Mori da Cunha, Gabriela Bomfim-Ferreira
المساهمون: Pathology/molecular and cellular medicine, Beta Cell Neogenesis
المصدر: Diabetologia
مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, endocrine system diseases, Endocrinology, Diabetes and Metabolism, chemistry.chemical_compound, 0302 clinical medicine, Stem Cells/cytology, Cells, Cultured, geography.geographical_feature_category, Stem Cells, Diabetes Mellitus, Type 1/physiopathology, Middle Aged, Islet, Vascular endothelial growth factor, medicine.anatomical_structure, Type 1 diabetes, Diabetes Mellitus, Experimental/physiopathology, Female, Islets of Langerhans/metabolism, Stem cell, Blood vessel, Adult, endocrine system, Stem Cell Transplantation/methods, Revascularisation, Neovascularization, Physiologic, Biology, Article, Diabetes Mellitus, Experimental, Andrology, 03 medical and health sciences, Islets of Langerhans, Diabetes mellitus, Internal Medicine, medicine, Animals, Humans, Progenitor cell, geography, Pancreatic islets, Neovascularization, Physiologic/physiology, medicine.disease, Transplantation, Mice, Inbred C57BL, Blood Glucose/physiology, Disease Models, Animal, 030104 developmental biology, Diabetes Mellitus, Type 1, chemistry, Immunology, 030217 neurology & neurosurgery, Stem Cell Transplantation
وصف الملف: Print-Electronic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd0848bad81ed436ba63625592f1b09Test
http://europepmc.org/articles/PMC6518081Test