Association between thyroid cancer and epidermal growth factor receptor mutation in female with nonsmall cell lung cancer
| العنوان: | Association between thyroid cancer and epidermal growth factor receptor mutation in female with nonsmall cell lung cancer |
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| المؤلفون: | Chang-Min Choi, Hye-Ryoun Kim, Joon Seon Song, Cheol Hyeon Kim, Im Il Na, Jae Soo Koh, Hee Jong Baek, Seo Yun Kim, Jae Cheol Lee |
| المصدر: | Annals of Thoracic Medicine, Vol 12, Iss 1, Pp 36-41 (2017) Annals of Thoracic Medicine |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, Oncology, endocrine system, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, endocrine system diseases, medicine.disease_cause, 03 medical and health sciences, nonsmall cell lung carcinoma, 0302 clinical medicine, Internal medicine, Medicine, Epidermal growth factor receptor, Family history, Lung cancer, Thyroid cancer, Thyroid neoplasm, lcsh:RC705-779, biology, business.industry, Cancer, Retrospective cohort study, lcsh:Diseases of the respiratory system, medicine.disease, 030104 developmental biology, female, lcsh:RC666-701, 030220 oncology & carcinogenesis, biology.protein, Adenocarcinoma, Original Article, Surgery, Cardiology and Cardiovascular Medicine, business, thyroid neoplasm |
| الوصف: | BACKGROUND: The aim of this study was to investigate the association between epidermal growth factor receptor (EGFR) mutation and thyroid cancer in female patients with nonsmall-cell lung cancer (NSCLC). METHODS: In a retrospective study, we examined 835 female patients who were diagnosed with NSCLC and underwent an EGFR mutation test between June 2003 and August 2013. The associations of EGFR mutation with thyroid cancer and a family history of thyroid cancer were evaluated using logistic regression models. RESULTS: EGFR mutation was found in 378 of 835 patients. In addition to adenocarcinoma (P < 0.001), EGFR mutations were positively associated with a personal history of thyroid cancer (5.8% versus 2.6%; P = 0.020), while showing a trend toward inverse association with a personal history of nonthyroid cancer (5.8% vs. 9.0%; P = 0.086). Likewise, the incidence of EGFR mutations was associated with a family history of thyroid cancer (2.9% vs. 0.9%; P = 0.028), while showing a trend toward inverse association with a family history of nonthyroid cancer (27.8% vs. 33.7%; P = 0.066). Multivariate logistic regression showed that the incidence of EGFR mutations was different in women with thyroid or nonthyroid cancer (P = 0.035) and in women with a family history of thyroid or nonthyroid cancer (P = 0.023). CONCLUSIONS: Our data suggest that thyroid cancer and a family history of thyroid cancer are associated with EGFR-mutated NSCLC in female patients. The differences in the incidence of thyroid cancer and a family history of thyroid cancer by EGFR mutational status provide new insight into pathogenesis of this genetic change. |
| اللغة: | English |
| تدمد: | 1998-3557 1817-1737 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b0bb8856e5c927feb5bf19e1edebc7Test http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2017;volume=12;issue=1;spage=36;epage=41;aulast=KimTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e8b0bb8856e5c927feb5bf19e1edebc7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983557 18171737 |
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