التفاصيل البيبلوغرافية
| العنوان: |
Hypothalamic ventromedial COUP-TFII protects against hypoglycemia-associated autonomic failure. |
| المؤلفون: |
Sabra-Makke, Lina, Maritan, Micol, Planchais, Julien, Boutant, Marie, Pégorier, Jean-Paul, Even, Patrick C., Vasseur-Cognet, Mireille, Bossard, Pascale |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America; 3/12/2013, Vol. 110 Issue 11, p4333-4338, 6p |
| مصطلحات موضوعية: |
HYPOTHALAMUS, HYPOGLYCEMIA, DYSAUTONOMIA, OVALBUMINS, TRANSCRIPTION factors |
| مستخلص: |
The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its function in different organs such as the endocrine pancreas, adipose tissue, skeletal muscle, and liver. Recently we have demonstrated that COUP-TFII expression in the hypothalamus is restricted to a subpopulation of neurons expressing the steroidogenic factor 1 transcription factor, known to play a crucial role in glucose homeostasis. To understand the functional significance of COUP-TFII expression in the steroidogenic factor 1 neurons, we generated hypothalamic ventromedial nucleus-specific COUP-TFII KO mice using the cyclization recombination/locus of X-overP1 technology. The heterozygous mutant mice display insulin hypersensitivity and a leaner phenotype associated with increased energy expenditure and similar food intake. These mutant mice also present a defective counterregulation to hypoglycemia with altered glucagon secretion. Moreover, the mutant mice are more likely to develop hypoglycemia-associated autonomic failure in response to recurrent hypoglycemic or glucopenic events. Therefore, COUP-TFII expression levels in the ventromedial nucleus are keys in the ability to resist the onset of hypoglycemia-associated autonomic failure. [ABSTRACT FROM AUTHOR] |
|
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder