التفاصيل البيبلوغرافية
| العنوان: |
Blood stream infection and outcomes in recipients of a left ventricular assist device. |
| المؤلفون: |
Angleitner, Philipp, Matic, Aleksa, Kaider, Alexandra, Dimitrov, Kamen, Sandner, Sigrid, Wiedemann, Dominik, Riebandt, Julia, Schlöglhofer, Thomas, Laufer, Günther, Zimpfer, Daniel |
| المصدر: |
European Journal of Cardio-Thoracic Surgery; Nov2020, Vol. 58 Issue 5, p907-914, 8p |
| مصطلحات موضوعية: |
HEART assist devices, EXTRACORPOREAL membrane oxygenation, INTRA-aortic balloon counterpulsation, HEART transplantation, BLOOD, RIVERS, CARDIAC surgery |
| الشركة/الكيان: |
MEDIZINISCHE Universitat Wien |
| مستخلص: |
OBJECTIVES Open in new tab Download slide Open in new tab Download slide Our aim was to investigate associations between blood stream infection [≥1 positive blood culture (BC)] and outcomes in recipients of a left ventricular assist device (LVAD). METHODS We retrospectively analysed all adult recipients of a continuous-flow LVAD between 2006 and 2016 at the Division of Cardiac Surgery, Medical University of Vienna (n = 257; devices: Medtronic HeartWare® HVAD®, Abbott HeartMate II®, Abbott HeartMate 3™). The primary outcome was all-cause mortality during follow-up. Secondary outcomes included the risk of stroke and pump thrombus during follow-up as well as the probability of heart transplantation (HTx). Risk factors for the development of ≥1 positive BC were evaluated additionally. RESULTS The incidence of ≥1 positive BC during the first year of LVAD support was 32.1% [95% confidence interval (CI) 26.4–37.9]. Multivariable Cox proportional cause-specific hazards regression analysis showed that a positive BC was associated with significantly increased all-cause mortality [hazard ratio (HR) 5.51, 95% CI 3.57–8.51; P < 0.001]. Moreover, a positive BC was associated with a significantly increased risk of stroke (HR 2.41, 95% CI 1.24–4.68; P = 0.010). There was no association with the risk of pump thrombus or the probability of HTx. Independent risk factors for a positive BC included preoperative albumin and extracorporeal membrane oxygenation/intra-aortic balloon pump support. CONCLUSIONS Blood stream infection is common and associated with a significantly increased risk of all-cause mortality and stroke at any given time during LVAD support. Effective strategies of prevention and treatment are necessary. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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