دورية أكاديمية
Pooled Analysis of 3 Randomized, Controlled Trials of Interleukin-2 Therapy in Adult Human Immunodeficiency Virus Type 1 Disease
| العنوان: | Pooled Analysis of 3 Randomized, Controlled Trials of Interleukin-2 Therapy in Adult Human Immunodeficiency Virus Type 1 Disease |
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| المؤلفون: | Emery, Sean, Capra, William B., Cooper, David A., Mitsuyasu, Ronald T., Kovacs, Joseph A., Vig, Pamela, Smolskis, Mary, Saravolatz, Louis D., Lane, H. Clifford, Fyfe, Gwen A., Curtin, Peter T., for the International Interleukin-2 Study Group |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2000 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Major Articles |
| الوصف: | We collected human immunodeficiency virus (HIV) disease progression, survival, most recent CD4 cell count, and plasma HIV RNA levels from patients ( n = 157) who participated in randomized clinical trials of interleukin (IL)–2 that commenced before 1995. Data were available for 155 (99%) patients. Statistical analyses were based on the intention-to-treat principle. Median follow-up was 28 months and 30 months for control and IL-2 patients, respectively. Twenty-five (16%) patients developed AIDS or died during follow-up (16 control patients vs. 9 IL-2 patients; R 2 = 0.57; P = .22). Mean change from baseline CD4 cell count was significantly higher in patients randomized to receive IL-2 (368 vs. 153 cells/µL; P = .003). Mean change from baseline plasma HIV RNA was significantly lower in patients randomized to receive IL-2 (−0.98 vs. −0.63 log copies/mL; P = .004). Significant improvements in CD4 cell count and plasma HIV RNA in recipients of IL-2 relative to control patients were associated with a nonsignificant trend toward improved clinical outcome. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://jid.oxfordjournals.org/cgi/content/short/182/2/428Test; http://dx.doi.org/10.1086/315736Test |
| DOI: | 10.1086/315736 |
| الإتاحة: | https://doi.org/10.1086/315736Test http://jid.oxfordjournals.org/cgi/content/short/182/2/428Test |
| حقوق: | Copyright (C) 2000, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.2500E14B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1086/315736 |
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