دورية أكاديمية
Age-adapted percentiles of measured glomerular filtration in healthy individuals:extrapolation to living kidney donors over 65 years
| العنوان: | Age-adapted percentiles of measured glomerular filtration in healthy individuals:extrapolation to living kidney donors over 65 years |
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| المؤلفون: | Delanaye, Pierre, Gaillard, François, van der Weijden, Jessica, Mjøen, Geir, Ferhman-Ekholm, Ingela, Dubourg, Laurence, Ebert, Natalie, Schaeffner, Elke, Åkerfeldt, Torbjörn, Goffin, Karolien, Couzi, Lionel, Garrouste, Cyril, Rostaing, Lionel, Courbebaisse, Marie, Legendre, Christophe, Hourmant, Maryvonne, Kamar, Nassim, Cavalier, Etienne, Weekers, Laurent, Bouquegneau, Antoine, de Borst, Martin H, Mariat, Christophe, Pottel, Hans, van Londen, Marco |
| المصدر: | Delanaye , P , Gaillard , F , van der Weijden , J , Mjøen , G , Ferhman-Ekholm , I , Dubourg , L , Ebert , N , Schaeffner , E , Åkerfeldt , T , Goffin , K , Couzi , L , Garrouste , C , Rostaing , L , Courbebaisse , M , Legendre , C , Hourmant , M , Kamar , N , Cavalier , E , Weekers , L , Bouquegneau , A , de Borst , M H , Mariat , C , Pottel , H & van Londen , .... |
| سنة النشر: | 2022 |
| المجموعة: | University of Groningen research database |
| الوصف: | OBJECTIVES: Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old. METHODS: mGFR percentiles were calculated from a development cohort of French/Belgian living kidney donors <65 years (n=1,983), using quantiles modeled as cubic splines (two linear parts joining at 40 years). Percentiles were extrapolated and validated in an internal cohort of donors ≥65 years (n=147, France) and external cohort of donors and healthy subjects ≥65 years (n=329, Germany, Sweden, Norway, France, The Netherlands) by calculating percentages within the extrapolated 5th-95th percentile (P5-P95). RESULTS: Individuals in the development cohort had a higher mGFR (99.9 ± 16.4 vs. 86.4 ± 14 and 82.7 ± 15.5 mL/min/1.73 m2) compared to the individuals in the validation cohorts. In the internal validation cohort, none (0%) had mGFR below the extrapolated P5, 12 (8.2%) above P95 and 135 (91.8%) between P5-P95. In the external validation cohort, five subjects had mGFR below the extrapolated P5 (1.5%), 25 above P95 (7.6%) and 299 (90.9%) between P5-P95. CONCLUSIONS: We demonstrate that extrapolation of mGFR from younger donors is possible and might aid with decision-making in elderly donors. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/17ac3651-3c3d-46fa-81c7-3d48d3e3ac35Test |
| DOI: | 10.1515/cclm-2021-1011 |
| الإتاحة: | https://doi.org/10.1515/cclm-2021-1011Test https://hdl.handle.net/11370/17ac3651-3c3d-46fa-81c7-3d48d3e3ac35Test https://research.rug.nl/en/publications/17ac3651-3c3d-46fa-81c7-3d48d3e3ac35Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6F2AF3CF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1515/cclm-2021-1011 |
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