دورية أكاديمية
Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice.
| العنوان: | Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. |
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| المؤلفون: | Wang, Vicki, Tseng, Kuan-Yin, Kuo, Tung-Tai, Huang, Eagle Yi-Kung, Lan, Kuo-Lun, Chen, Zi-Rong, Ma, Kuo-Hsing, Greig, Nigel H, Jung, Jin, Choi, Ho-Ii, Olson, Lars, Hoffer, Barry J, Chen, Yuan-Hao |
| المصدر: | J Biomed Sci ; ISSN:1423-0127 ; Volume:31 ; Issue:1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Exenatide, Glucagon-like peptide-1 receptor agonist, MitoPark mouse, Mitochondria, PT320, Parkinson’s disease |
| الوصف: | Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial dysfunction is closely linked to neurodegenerative diseases. Glucagon-like peptide-1 receptor (GLP-1R) agonist has gained interest as a potential treatment for Parkinson's disease (PD). However, the exact mechanisms responsible for the therapeutic effects of GLP-1R-related agonists are not yet fully understood. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1186/s12929-024-01025-6Test; https://pubmed.ncbi.nlm.nih.gov/38627765Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11022395Test/ |
| DOI: | 10.1186/s12929-024-01025-6 |
| الإتاحة: | https://doi.org/10.1186/s12929-024-01025-6Test https://pubmed.ncbi.nlm.nih.gov/38627765Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11022395Test/ |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.EE40E9C8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12929-024-01025-6 |
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