مراجعة
A concise review of inflammatory biomarkers targeted cancer therapy
| العنوان: | A concise review of inflammatory biomarkers targeted cancer therapy |
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| المؤلفون: | Shah,Ashish, Patel,Chhagan |
| المصدر: | Folia Medica 64(4): 572-580 |
| بيانات النشر: | Plovdiv Medical University |
| سنة النشر: | 2022 |
| المجموعة: | Pensoft Publishers |
| مصطلحات موضوعية: | anti-inflammatory agents, cancer, cancer prevention, inflammation, inflammatory biomarkers |
| الوصف: | Inflammation is considered a general protective reaction of localized tissue against injury, irritation, or swelling. Inflammation may be acute, which is part of the defensive response; or chronic, which may lead to the development of various diseases including cancer. Several pro-inflammatory genes play important role in the various cellular processes like cell proliferation, angiogenesis, metastasis, and suppression of apoptosis. These pro-inflammatory genes include TNF-α, interleukins, chemokines, MMPs, cyclooxygenase, lipoxygenase, iNOS, Jak/STAT pathway, etc. All these genes are mainly regulated by the transcription factor NF-κB, which is found active in many types of neoplastic cells. Therefore, developing molecules that target pro-inflammatory genes or transcription factor is believed to be one of the good strategies for development of anti-cancer agents. Literature data suggest that many anti-inflammatory agents, including non-steroidal anti-inflammatory drugs, corticosteroids, statins, metformin, embelin, and some natural products, can interfere with the tumor microenvironment by inhibiting pro-inflammatory genes or transcription factors and increasing cell apoptosis. This review describes the link between inflammation and cancer, the role of pro-inflammatory genes and transcription factors in the development of tumor cells, and the use of anti-inflammatory agents in cancer. |
| نوع الوثيقة: | review |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/eissn/1314-2143; info:eu-repo/semantics/altIdentifier/pissn/0204-8043 |
| DOI: | 10.3897/folmed.64.e68365 |
| الإتاحة: | https://doi.org/10.3897/folmed.64.e68365Test https://foliamedica.bg/article/68365Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CDDAFBCE |
| قاعدة البيانات: | BASE |
| DOI: | 10.3897/folmed.64.e68365 |
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