المؤلفون: Grimsmann, Julia M., Gesuita, Rosaria, Cherubini, Valentino, Åkesson, Karin, Birkebæk, Niels H., Rami-Merhar, Birgit, Cinek, Ondrej, Dovč, Klemen, Gregory, John W.

مصطلحات موضوعية: Children with diabetes, Complications, Diabetic ketoacidosis, Diagnosis of diabetes, Epidemiology, Type 1 diabetes

جغرافية الموضوع: UMW:14638

الوصف: Aims/hypothesis The aim of this work was to evaluate geographical variability and trends in the prevalence of diabetic ketoacidosis (DKA), between 2006 and 2016, at the diagnosis of childhood-onset type 1 diabetes in 13 countries over three continents. Methods An international retrospective study on DKA at diagnosis of diabetes was conducted. Data on age, sex, date of diabetes diagnosis, ethnic minority status and presence of DKA at diabetes onset were obtained from Australia, Austria, Czechia, Denmark, Germany, Italy, Luxembourg, New Zealand, Norway, Slovenia, Sweden, USA and the UK (Wales). Mean prevalence was estimated for the entire period, both overall and by country, adjusted for sex and age group. Temporal trends in annual prevalence of DKA were estimated using logistic regression analysis for each country, before and after adjustment for sex, age group and ethnic minority status. Results During the study period, new-onset type 1 diabetes was diagnosed in 59,000 children (median age [interquartile range], 9.0 years [5.5–11.7]; male sex, 52.9%). The overall adjusted DKA prevalence was 29.9%, with the lowest prevalence in Sweden and Denmark and the highest in Luxembourg and Italy. The adjusted DKA prevalence significantly increased over time in Australia, Germany and the USA while it decreased in Italy. Preschool children, adolescents and children from ethnic minority groups were at highest risk of DKA at diabetes diagnosis in most countries. A significantly higher risk was also found for females in Denmark, Germany and Slovenia. Conclusions/interpretation DKA prevalence at type 1 diabetes diagnosis varied considerably across countries, albeit it was generally high and showed a slight increase between 2006 and 2016. Increased awareness of symptoms to prevent delay in diagnosis is warranted, especially in preschool children, adolescents and children from ethnic minority groups.

وصف الملف: text/html

العلاقة: vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-59889/128Test; urn:nbn:at:at-ubmuw:3-59889; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-59889Test; local:99146883352003331; system:AC16577923

الإتاحة: https://doi.org/10.1007/s00125-020-05152-1Test
https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-59889Test

المؤلفون: Hovorka, Roman, Musolino, Gianluca, Dovc, Klemen, Boughton, Charlotte K., Tauschmann, Martin, Allen, Janet M., Nagl, Katrin, Fritsch, Maria, Yong, James, Metcalfe, Emily, Schaeffer, Dominique, Fichelle, Muriel, Schierloh, Ulrike, Thiele, Alena G., Abt, Daniela, Kojzar, Harald, Mader, Julia K., Slegtenhorst, Sonja, Ashcroft, Nicole, Wilinska, Malgorzata E., Sibayan, Judy, Cohen, Nathan, Kollman, Craig, Hofer, Sabine E., Fröhlich-Reiterer, Elke

مصطلحات موضوعية: artificial pancreas, closed‐loop insulin delivery, type 1 diabetes, very young children

جغرافية الموضوع: UMW:14638

الوصف: Objective To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day‐and‐night hybrid closed‐loop insulin delivery. Methods Parents/caregivers of 20 children aged 1 to 7 years with type 1 diabetes completed a closed‐loop experience survey following two 3‐week periods of unrestricted day‐and‐night hybrid closed‐loop insulin therapy using Cambridge FlorenceM system at home. Benefits, limitations, and improvements of closed‐loop technology were explored. Results Responders reported reduced burden of diabetes management, less time spent managing diabetes, and improved quality of sleep with closed‐loop. Ninety percent of the responders felt less worried about their child's glucose control using closed‐loop. Size of study devices, battery performance and connectivity issues were identified as areas for improvement. Parents/caregivers wished for more options to input information to the system such as temporary glucose targets. Conclusions Parents/caregivers of very young children reported important quality of life benefits associated with using closed‐loop, supporting adoption of this technology in this population.

وصف الملف: text/html

العلاقة: vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-34629/128Test; urn:nbn:at:at-ubmuw:3-34629; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-34629Test; local:99145832359703331; system:AC16138783

الإتاحة: https://doi.org/10.1111/pedi.12872Test
https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-34629Test