دورية أكاديمية
Mendelian breeding units versus standard sampling strategies: Mitochondrial DNA variation in southwestern Sardinia
| العنوان: | Mendelian breeding units versus standard sampling strategies: Mitochondrial DNA variation in southwestern Sardinia |
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| المؤلفون: | Sanna D, Cossu P, Dedola GL, Melis S, Fresu G, Morelli L, Obinu D, Tonolo G, Secchi G, Triunfo R, Lorenz JG, Scheinfeldt L, Robledo R, Francalacci P., PALA, MARIA, TORRONI, ANTONIO |
| المساهمون: | Sanna, D, Pala, Maria, Cossu, P, Dedola, Gl, Melis, S, Fresu, G, Morelli, L, Obinu, D, Tonolo, G, Secchi, G, Triunfo, R, Lorenz, Jg, Scheinfeldt, L, Torroni, Antonio, Robledo, R, Francalacci, P. |
| سنة النشر: | 2011 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | LINKAGE DISEQUILIBRIUM, POPULATION-GENETICS, DISEASE, ORIGIN, GENOME, BREEDING UNITS STRATEGY, MTDNA HAPLOGROUP DISTRIBUTION, ASSOCIATION STUDIES |
| الوصف: | We report a sampling strategy based on Mendelian Breeding Units (MBUs), representing an interbreeding group of individuals sharing a common gene pool. The identification of MBUs is crucial for case-control experimental design in association studies. The aim of this work was to evaluate the possible existence of bias in terms of genetic variability and haplogroup frequencies in the MBU sample, due to severe sample selection. In order to reach this goal, the MBU sampling strategy was compared to a standard selection of individuals according to their surname and place of birth. We analysed mitochondrial DNA variation (first hypervariable segment and coding region) in unrelated healthy subjects from two different areas of Sardinia: the area around the town of Cabras and the western Campidano area. No statistically significant differences were observed when the two sampling methods were compared, indicating that the stringent sample selection needed to establish a MBU does not alter original genetic variability and haplogroup distribution. Therefore, the MBU sampling strategy can be considered a useful tool in association studies of complex traits. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21734814; info:eu-repo/semantics/altIdentifier/wos/000290865300003; volume:34; issue:2; firstpage:187; lastpage:194; numberofpages:8; journal:GENETICS AND MOLECULAR BIOLOGY; http://hdl.handle.net/11571/243297Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79957916034; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115307/?tool=pubmedTest |
| DOI: | 10.1590/S1415-47572011000200003 |
| الإتاحة: | https://doi.org/10.1590/S1415-47572011000200003Test http://hdl.handle.net/11571/243297Test http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115307/?tool=pubmedTest |
| رقم الانضمام: | edsbas.9777D164 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1590/S1415-47572011000200003 |
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