Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinsons disease
| العنوان: | Mitochondrial dysfunction and biogenesis in the pathogenesis of Parkinsons disease |
|---|---|
| المؤلفون: | Tsu-Kung Lin, Cha-Wei Liou, Shang-Der Chen, Yao-Chung Chuang, Mao-Meng Tiao, Pei-Wen Wang, Jin-Bor Chen, Jiin-Haur Chuang |
| المساهمون: | 輔英科技大學 護理系 |
| سنة النشر: | 2009 |
| المجموعة: | Fooyin University Institutional Repository (FYIR) |
| مصطلحات موضوعية: | Parkinson’s disease, mitochondrial dysfunction, mitochondrial biogenesis, genes, cell survival and death |
| الوصف: | Parkinson’s disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration and development of cytoplasmic aggregates known as Lewy bodies. The impact of this disease is indicated by the fact that mortality is two to five times as high among affected persons as among age-matched controls. However, the cause of PD is still unknown and no cure is available at present. Several biochemical abnormalities have been described in the brains of patients with PD, including oxidative stress and mitochondrial dysfunction. Recent identification of specific gene mutations that cause PD has further reinforced the relevance of oxidative stress and mitochondrial dysfunction in the familial and sporadic forms of the disease. The proteins that are reported to be related to familial PD–PTEN-induced putative kinase 1 (PINK1), DJ-1, α- synuclein, leucine-rich repeat kinase 2 (LRRK2), and, possibly, parkin–are either mitochondrial proteins or are associated with mitochondria, and all are involved in pathways that elicit oxidative stress or free radical damage. Mitochondria are continually exposed to reactive oxygen species and accumulate oxidative damage more rapidly than the rest of the cell. Therefore, Parkinson’s disease has been suggested to be associated with mitochondrial dysfunction. Since mitochondria are the major intracellular organelles that regulate both cell survival and death, clarifying the involvement of mitochondrial dysfunction and biogenesis during the process of PD could provide treatment strategies that might successfully intervene in the pathogenesis and slow the progression of the disease. (Chang Gung Med J 2009 ; 32:589-99) |
| نوع الوثيقة: | other/unknown material |
| اللغة: | English |
| العلاقة: | Chang Gung Medical Journal 32(6),589-599; http://ir.fy.edu.tw/ir/handle/987654321/524Test; http://ir.fy.edu.tw/ir/bitstream/987654321/524/2/index.htmlTest; http://ir.fy.edu.tw/ir/bitstream/987654321/524/1/index.htmlTest |
| الإتاحة: | http://ir.fy.edu.tw/ir/handle/987654321/524Test http://ir.fy.edu.tw/ir/bitstream/987654321/524/2/index.htmlTest http://ir.fy.edu.tw/ir/bitstream/987654321/524/1/index.htmlTest |
| رقم الانضمام: | edsbas.786DF073 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |