التفاصيل البيبلوغرافية
| العنوان: |
Receptor through a Proteosome-Mediated Protein Degradation Pathway |
| المؤلفون: |
Neonatal Estrogen, Down-regulates Prostatic Androgen, Carl Woodham Lynn Birch |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://endo.endojournals.org/content/144/11/4841.full.pdfTest. |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
DTT, dithiothreitol, E1, ubiquitin-activating enzmye, E2, ubiquitin-conjugating enzyme, E3, ubiquitin-protein ligase, EB, estradiol benzoate, ER, estrogen receptor, PEST, regions enriched in Pro, Glu, Ser, and Thr, PIN, prostatic intraepithelial neoplasia, PR, progesterone receptor |
| الوصف: |
quantitative; rAR, rat AR; RAR, retinoic acid receptor; SDS, sodium dodecyl sulfate; UTR, untranslated region. Brief exposure of male rats to estrogens during the neonatal period interrupts normal prostate development, alters epithelial cell differentiation, and predisposes this gland to hyperplasia and severe dysplasia analogous to prostatic intraepithelial neoplasia (PIN) with aging. Previous work demonstrated that the reduced growth, secretory activity, and androgen sensitivity that are observed in the adult ventral lobe are a function of reduced androgen receptor (AR) levels. Down-regulation of AR protein was found to occur immediately following neonatal exposure to estradiol benzoate (EB) and persist through adulthood and aging, indicating a permanent imprint on the ability of the prostate to express normal AR levels. To determine the intracellular mechanism |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.4908Test; http://endo.endojournals.org/content/144/11/4841.full.pdfTest |
| الإتاحة: |
http://endo.endojournals.org/content/144/11/4841.full.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.18DFA3DC |
| قاعدة البيانات: |
BASE |
