دورية أكاديمية
Extracellular Vesicles in Chronic Obstructive Pulmonary Disease
| العنوان: | Extracellular Vesicles in Chronic Obstructive Pulmonary Disease |
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| المؤلفون: | Tsukasa Kadota, Yu Fujita, Yusuke Yoshioka, Jun Araya, Kazuyoshi Kuwano, Takahiro Ochiya |
| المصدر: | International Journal of Molecular Sciences, Vol 17, Iss 11, p 1801 (2016) |
| بيانات النشر: | MDPI AG, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | COPD, extracellular vesicles, exosome, microRNA, microvesicle, pathogenesis, biomarker, therapy, exacerbation, endothelial microparticle, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Chronic obstructive pulmonary disease (COPD) is characterized by the progression of irreversible airflow limitation and is a leading cause of morbidity and mortality worldwide. Although several crucial mechanisms of COPD pathogenesis have been studied, the precise mechanism remains unknown. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from almost all cell types and are recognized as novel cell–cell communication tools. They have been shown to carry and transfer a wide variety of molecules, such as microRNAs, messenger RNAs, and proteins, which are involved in physiological functions and the pathology of various diseases. Recently, EVs have attracted considerable attention in pulmonary research. In this review, we summarize the recent findings of EV-mediated COPD pathogenesis. We also discuss the potential clinical usefulness of EVs as biomarkers and therapeutic agents for the treatment of COPD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | http://www.mdpi.com/1422-0067/17/11/1801Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms17111801 |
| الوصول الحر: | https://doaj.org/article/85b2bd8cd6b844b9b67e117b2bc61800Test |
| رقم الانضمام: | edsdoj.85b2bd8cd6b844b9b67e117b2bc61800 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms17111801 |