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1

Superior Mesenteric Artery Syndrome Accompanied by Acute-onset Type 1 Diabetes Complicated with Graves' Disease

المؤلفون: Eijiro Yamada, Yasuyo Nakajima, Emi Ishida, Satoshi Yoshino, Shuichi Okada, Kazuhiko Horiguchi, Shunichi Matsumoto, Mai Sue-Nagumo, Masanobu Yamada

المصدر: Internal Medicine. 61:1555-1560

الوصف: A 35-year-old man experienced general fatigue and could not eat solid food because of nausea and vomiting. His weight abruptly decreased from 49 to 45 kg after 2 weeks. A detailed examination indicated superior mesenteric artery syndrome (SMAS) accompanied by acute-onset type 1 diabetes complicated by Graves' disease, referred to as autoimmune polyglandular syndrome type 3A (APS3A). Although SMAS has a good prognosis, some cases require emergency surgery, especially when complicated by gastric perforation. In our case, APS3A and SMAS developed rapidly and at approximately the same time, resulting in a cycle of mutual exacerbation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f59ada3f465d5c49610b5ffca899b8Test
https://doi.org/10.2169/internalmedicine.8364-21Test

2

Association between Metabolic Syndrome and Microvascular Complications in Chinese Adults with Type 1 Diabetes Mellitus

المؤلفون: Jinhua Yan, Jianping Weng, Bin Yao, Xueying Zheng, Sihui Luo, Hua Liang, Qianwen Huang, Hongrong Deng, Xiangwen Liu, Daizhi Yang, Wen Xu

المصدر: Diabetes & Metabolism Journal, Vol 46, Iss 1, Pp 93-103 (2022)

الوصف: Background: Both type 1 diabetes mellitus (T1DM) and metabolic syndrome (MetS) are associated with an elevated risk of morbidity and mortality yet with increasing heterogeneity. This study primarily aimed to evaluate the prevalence of MetS among adult patients with T1DM in China and investigate its associated risk factors, and relationship with microvascular complications.Methods: We included adult patients who had been enrolled in the Guangdong T1DM Translational Medicine Study conducted from June 2010 to June 2015. MetS was defined according to the updated National Cholesterol Education Program criterion. Logistic regression models were used to estimate the odds ratio (OR) for the association between MetS and the risk of diabetic kidney disease (DKD) and diabetic retinopathy (DR).Results: Among the 569 eligible patients enrolled, the prevalence of MetS was 15.1%. While female gender, longer diabetes duration, higher body mass index, and glycosylated hemoglobin A1c (HbA1c) were risk factors associated with MetS (OR, 2.86, 1.04, 1.14, and 1.23, respectively), received nutrition therapy education was a protective factor (OR, 0.46). After adjustment for gender, age, diabetes duration, HbA1c, socioeconomic and lifestyle variables, MetS status was associated with an increased risk of DKD and DR (OR, 2.14 and 3.72, respectively; both P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cc0744ff91b4098b6b8c2e51b98b81Test
http://www.e-dmj.org/upload/pdf/dmj-2020-0240.pdfTest

3

Soluble programmed cell death-1 predicts hepatocellular carcinoma development during nucleoside analogue treatment

المؤلفون: Hiroyuki Motoyama, Norifumi Kawada, Kohei Kotani, Akihiro Tamori, Naoshi Odagiri, Hideki Fujii, Hoang Hai, Le Thi Thanh Thuy, Atsushi Hagihara, Minh Phuong Dong, Masaru Enomoto, Ritsuzo Kozuka, Etsushi Kawamura, Sawako Uchida-Kobayashi, Kanako Yoshida

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports

الوصف: Soluble immune checkpoint molecules are emerging novel mediators of immune regulation. However, it is unclear whether soluble immune checkpoint proteins affect the development of hepatocellular carcinoma (HCC) during nucleos(t)ide analogue (NA) treatment in patients with chronic hepatitis B virus infection. This study included 122 NA-naïve patients who received NA therapy. We assessed the associations of clinical factors, including soluble immune checkpoint proteins, with HCC development during NA treatment. The baseline serum concentrations of 16 soluble immune checkpoint proteins were measured using multiplexed fluorescent bead-based immunoassay. In total, 13 patients developed HCC during the follow-up period (median duration, 4.3 years). Of the 16 proteins, soluble inducible T-cell co-stimulator (≥ 164.71 pg/mL; p = 0.014), soluble programmed cell death-1 (sPD-1) (≤ 447.27 pg/mL; p = 0.031), soluble CD40 (≤ 493.68 pg/mL; p = 0.032), and soluble herpes virus entry mediator (≤ 2470.83 pg/mL; p = 0.038) were significantly associated with HCC development (log-rank test). In multivariate analysis, an sPD-1 level ≤ 447.27 pg/mL (p = 0.014; hazard ratio [HR], 4.537) and α-fetoprotein level ≥ 6.4 ng/mL (p = 0.040; HR, 5.524) were independently and significantly associated with HCC development. Pre-treatment sPD-1 is a novel predictive biomarker for HCC development during NA treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4450d2a03fa611a7dd2cf18678b8b541Test
https://doaj.org/article/68f24d6e6a1041038229292cc77e750cTest

4

PD‐L1 expression is associated with the spontaneous regression of patients with methotrexate‐associated lymphoproliferative disorders

المؤلفون: Tadashi Yoshino, Naoya Nakamura, Misa Sakamoto, Tomoka Ikeda, Yuria Egusa, Yoshito Nishimura, Yasuharu Sato, Azusa Fujita, Misato Doi, Noriko Iwaki, Asami Nishikori, Midori Filiz Nishimura, Yuka Gion

المصدر: Cancer Medicine, Vol 11, Iss 2, Pp 417-432 (2022)
Cancer Medicine

مصطلحات موضوعية: Male, rheumatoid arthritis, Cancer Research, medicine.medical_treatment, Remission, Spontaneous, Spontaneous remission, Kaplan-Meier Estimate, Gastroenterology, B7-H1 Antigen, Arthritis, Rheumatoid, Pathogenesis, programmed cell death‐ligand 1, rheumatoid arthritis, immune system diseases, hemic and lymphatic diseases, heterocyclic compounds, skin and connective tissue diseases, Research Articles, classic Hodgkin lymphoma, RC254-282, Aged, 80 and over, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Hodgkin Disease, Oncology, Antirheumatic Agents, Female, Lymphoma, Large B-Cell, Diffuse, Research Article, medicine.drug, Adult, musculoskeletal diseases, medicine.medical_specialty, methotrexate‐associated lymphoproliferative disorder, diffuse large B-cell lymphoma, Lymphoproliferative disorders, programmed cell death-ligand 1, Internal medicine, medicine, Humans, methotrexate-associated lymphoproliferative disorder, Radiology, Nuclear Medicine and imaging, Aged, Chemotherapy, business.industry, diffuse large B‐cell lymphoma, Clinical Cancer Research, medicine.disease, Lymphoma, Discontinuation, Methotrexate, business, Diffuse large B-cell lymphoma

الوصف: Background Most patients with methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) show diffuse large B‐cell lymphoma (DLBCL) or classic Hodgkin lymphoma (CHL) types. Patients with MTX‐LPD often have spontaneous remission after MTX discontinuation, but chemotherapeutic intervention is frequently required in patients with CHL‐type MTX‐LPD. In this study, we examined whether programmed cell death‐ligand 1 (PD‐L1) expression levels were associated with the prognosis of MTX‐LPD after MTX discontinuation. Methods A total of 72 Japanese patients diagnosed with MTX‐LPD were clinicopathologically analyzed, and immunohistochemical staining of PD‐L1 was performed in 20 DLBCL‐type and 24 CHL‐type MTX‐LPD cases to compare with the clinical course. Results PD‐L1 was expressed in 5.0% (1/20) of patients with DLBCL‐type MTX‐LPD, whereas it was expressed in 66.7% (16/24) of the patients with CHL‐type MTX‐LPD in more than 51% of tumor cells. Most CHL‐type MTX‐LPD patients with high PD‐L1 expression required chemotherapy owing to exacerbations or relapses after MTX discontinuation. However, no significant differences in clinicopathologic findings at diagnosis were observed between PD‐L1 high‐ and low‐expression CHL‐type MTX‐LPD. Conclusion PD‐L1 expression was significantly higher in patients with CHL‐type than DLBCL‐type MTX‐LPD, suggesting the need for chemotherapy in addition to MTX discontinuation in CHL‐type MTX‐LPD patients to achieve complete remission. No association was observed between PD‐L1 expression levels and clinical findings at diagnosis, suggesting that PD‐L1 expression in tumor cells influences the pathogenesis of CHL‐type MTX‐LPD after MTX discontinuation.
Patients with classic Hodgkin lymphoma (CHL)‐type methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) with high programmed cell death‐ligand 1 (PD‐L1) expression tended to have exacerbations and relapses after MTX discontinuation. Our study suggests that the PD‐1/PD‐L1 pathway may be involved in refractoriness to MTX discontinuation in CHL‐type MTX‐LPD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0febac51292e55b26e6f5b3df183fcd5Test
https://doaj.org/article/6e2da9f68eeb4074af0bba01de8c7953Test

5

Insulin resistance and risk of vascular events, interventions and mortality in type 1 diabetes

المؤلفون: Frank L.J. Visseren, Wendela L de Ranitz, Jan Westerink, Harold W. de Valk, Marieke de Vries, Marga A G Helmink

المصدر: European Journal of Endocrinology. 185:831-840

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Aortic Rupture, Endocrinology, Diabetes and Metabolism, Myocardial Infarction, Disease, Lower risk, Amputation, Surgical, Cohort Studies, Young Adult, Endocrinology, Insulin resistance, Cause of Death, Internal medicine, Myocardial Revascularization, medicine, Humans, Prospective Studies, Mortality, Risk factor, Prospective cohort study, Proportional Hazards Models, Heart Failure, Type 1 diabetes, business.industry, Proportional hazards model, General Medicine, Middle Aged, Subarachnoid Hemorrhage, medicine.disease, Stroke, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Cohort, Linear Models, Female, Insulin Resistance, business, Vascular Surgical Procedures, Aortic Aneurysm, Abdominal

الوصف: Objective To identify determinants associated with insulin resistance and to assess the association between insulin resistance and cardiovascular events, vascular interventions and mortality in people with type 1 diabetes at high risk of cardiovascular disease. Design Prospective cohort study. Methods One hundred and ninety-five people with type 1 diabetes from the Secondary Manifestations of ARTerial disease (SMART) cohort were included. Insulin resistance was quantified by the estimated glucose disposal rate (eGDR) with higher eGDR levels indicating higher insulin sensitivity (i.e. lower eGDR levels indicating higher insulin resistance). Linear regression models were used to evaluate determinants associated with eGDR. The effect of eGDR on cardiovascular events, cardiovascular events or vascular interventions (combined endpoint) and on all-cause mortality was analysed using Cox proportional hazards models adjusted for confounders. Results In 195 individuals (median follow-up 12.9 years, IQR 6.7–17.0), a total of 25 cardiovascular events, 26 vascular interventions and 27 deaths were observed. High eGDR as a marker for preserved insulin sensitivity was independently associated with a lower risk of cardiovascular events (HR: 0.75; 95% CI: 0.61–0.91), a lower risk of cardiovascular events and vascular interventions (HR: 0.74; 95% CI: 0.63–0.87) and a lower risk of all-cause mortality (HR: 0.81; 95% CI: 0.67–0.98). Conclusions Insulin resistance as measured by eGDR is an additional risk factor for cardiovascular disease in individuals with type 1 diabetes. Modification of insulin resistance by lifestyle interventions or pharmacological treatment could be a viable therapeutic target to lower the risk of cardiovascular disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d2b0be0ef4827423e6968feb2b3cabTest
https://doi.org/10.1530/eje-21-0636Test

6

Association of High-Affinity Autoantibodies With Type 1 Diabetes High-Risk HLA Haplotypes

المؤلفون: Peter A. Gottlieb, Taylor K. Armstrong, Liping Yu, Andrea K. Steck, Hali C. Broncucia, Taylor M. Triolo, Laura Pyle

المصدر: J Clin Endocrinol Metab

الوصف: Objective Electrochemiluminescence (ECL) assays are high-affinity autoantibody (Ab) tests that are more specific than Abs detected by traditional radiobinding assays (RBA) for risk screening and prediction of progression to type 1 diabetes. We sought to characterize the association of high-risk human leukocyte antigen (HLA) haplotypes and genotypes with ECL positivity and levels in relatives of individuals with type 1 diabetes. Methods We analyzed 602 participants from the TrialNet Pathway to Prevention Study who were positive for at least 1 RBA diabetes-related Ab [glutamic acid decarboxylase autoantibodies (GADA) or insulin autoantibodies (IAA)] and for whom ECL and HLA data were available. ECL and RBA Ab levels were converted to SD units away from mean (z-scores) for analyses. Results Mean age at initial visit was 19.4 ± 13.7 years; 344 (57.1%) were female and 104 (17.3%) carried the high-risk HLA-DR3/4*0302 genotype. At initial visit 424/602 (70.4%) participants were positive for either ECL-GADA or ECL-IAA, and 178/602 (29.6%) were ECL negative. ECL and RBA-GADA positivity were associated with both HLA-DR3 and DR4 haplotypes (all Ps < 0.05), while ECL and RBA-GADA z-score titers were higher in participants with HLA-DR3 haplotypes only (both Ps < 0.001). ECL-IAA (but not RBA-IAA) positivity was associated with the HLA-DR4 haplotype (P < 0.05). Conclusions ECL-GADA positivity is associated with the HLA-DR3 and HLA-DR4 haplotypes and levels are associated with the HLA-DR3 haplotype. ECL-IAA positivity is associated with HLA-DR4 haplotype. These studies further contribute to the understanding of genetic risk and islet autoimmunity endotypes in type 1 diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0170d7002611843585520f581f2a03ccTest
https://doi.org/10.1210/clinem/dgab853Test

7

Comparative clinical outcomes of insulin degludec and insulin glargine 300 U/mL after switching from other basal insulins in real‐world patients with type 1 and type 2 diabetes

المؤلفون: Yukiko Hasegawa, Tetsuya Babazono, Junko Oya, Aki Katamine, Tomoko Nakagami, Yuichiro Kondo

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 11, Pp 1983-1991 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Insulin degludec, Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulins, Insulin Glargine, Type 2 diabetes, 030204 cardiovascular system & hematology, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Japan, Drug Substitution, Insulin glargine 300 U/mL, General Medicine, Articles, Middle Aged, Insulin, Long-Acting, Treatment Outcome, Clinical Science and Care, Female, Original Article, medicine.drug, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Real‐world clinical setting, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Aged, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Insulin glargine, business.industry, Insulin, medicine.disease, RC648-665, Endocrinology, Diabetes Mellitus, Type 1, Logistic Models, Basal (medicine), chemistry, Diabetes Mellitus, Type 2, Glycated hemoglobin, business

الوصف: Aims/Introduction To evaluate and compare the efficacy of insulin degludec (IDeg) and insulin glargine 300 U/mL (Gla300) 6 months after switching from other basal insulins by assessing the changes in glycated hemoglobin (HbA1c), body mass index (BMI), and insulin doses in patients with type 1 and type 2 diabetes in a real‐world clinical setting. Materials and Methods A total of 307 patients with type 1 diabetes and 294 patients with type 2 diabetes with HbA1c >7.0% were studied. Adjusted mean changes in HbA1c, BMI, and insulin doses were compared between IDeg (IDeg group) and Gla300 (Gla300 group) switchers. Multivariable logistic regression analyses were carried out to examine whether the IDeg or Gla300 group was associated with HbA1c or insulin dose reduction and BMI gain. Results HbA1c was significantly decreased in both the IDeg and Gla300 groups. Adjusted mean changes in HbA1c (approximately −0.3% and −0.5% in type 1 diabetes and type 2 diabetes patients, respectively) and BMI were similar between both groups. The mean change in insulin dose was slightly larger for dose reduction in the IDeg group than in the Gla300 group. Multivariable logistic regression models showed that the IDeg group was significantly associated with insulin dose reduction after adjusting for basal insulin type, insulin dose, and number of basal insulin injections at baseline and other confounding factors. Conclusions The current study suggested that IDeg and Gla300 have similar effects in reducing HbA1c and gaining BMI after switching from other basal insulins in Japanese patients with type 1 diabetes and type 2 diabetes. IDeg selection was associated with insulin dose reduction.
Insulin degludec and insulin glargine 300 U/mL showed similar values of reduction in glycated hemoglobin with body mass index almost unchanged 6 months after switching from other basal insulins in both type 1 and type 2 diabetes patients. Switching to insulin degludec was significantly associated with a reduction of basal and total insulin doses in both type 1 and type 2 diabetes patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8e343952d329f98d4b6977a3a8fce5Test
https://doaj.org/article/33e2f17798204034beea375b21f2d506Test

8

Variations in Sleep Characteristics and Glucose Regulation in Young Adults With Type 1 Diabetes

المؤلفون: Sanjay Rajagopalan, Stephanie Griggs, Margaret Grey, Seunghee Margevicius, Chiang-Shan R Li, Sybil L. Crawford, Ronald L. Hickman, Sangeeta R. Kashyap, Kingman P. Strohl

المصدر: J Clin Endocrinol Metab

الوصف: Context Short sleep duration and sleep disruptions are associated with impaired glucoregulation in type 1 diabetes (T1D). However, the mechanistic pathways between sleep and glucose variability remain unclear. Objective To determine within- and between-person associations between objective sleep-wake characteristics and glucose variability indices. Methods Multilevel models were used to analyze concurrent sleep and glucose patterns over 7 days in 42 young adults with T1D in their natural home environment. Young adults with T1D (mean age 22.2 ± 3.0 years, HbA1c 7.2%, 32.6% male) for at least 6 months with no other medical or major psychiatric comorbidity were included. Sleep-wake characteristics were measured via wrist actigraphy and glucose variability indices via a continuous glucose monitor (CGM). Results Lower sleep efficiency predicted higher glucose variability (less time in range β = 0.011 and more time in hyperglycemia β = −0.011) within-person. A longer wake after sleep onset and more sleep disruptions were associated with higher glucose variability between persons (β = 0.28 and 0.31). Higher glucose variability predicted poorer sleep within-person (delayed bedtime, waketime, mid-sleep time, and lower sleep efficiency), while higher glucose variability was associated with poorer sleep and more sleep disruptions between persons (lower sleep efficiency, longer wake after sleep onset, and a higher sleep fragmentation index). Conclusion Clinicians can address the reciprocal nature of the sleep-glucose relationship by optimizing sleep and targeting efforts toward a euglycemic range overnight. Sleep habits are a modifiable personal target in diabetes care.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b09ce5068bc6211487798eadc0095Test
https://doi.org/10.1210/clinem/dgab771Test

9

Prediction of Personal Glycemic Responses to Food for Individuals With Type 1 Diabetes Through Integration of Clinical and Microbial Data

المؤلفون: Nehama Zuckerman Levin, Yitav Glantz-Gashai, Naim Shehadeh, Eran Segal, Tal Karady, Bat Chen Wolf, Adina Weinberger, Smadar Shilo, Neriya Levran, Orit Pinhas-Hamiel, Dmitry Kolobkov, Shlomit Koren, Noam Bar, Tal Korem, Marianna Rachmiel, Noah Gruber, Anastasia Godneva, Michal Cohen

المصدر: Diabetes Care. 45:502-511

الوصف: OBJECTIVE Despite technological advances, results from various clinical trials have repeatedly shown that many individuals with type 1 diabetes (T1D) do not achieve their glycemic goals. One of the major challenges in disease management is the administration of an accurate amount of insulin for each meal that will match the expected postprandial glycemic response (PPGR). The objective of this study was to develop a prediction model for PPGR in individuals with T1D. RESEARCH DESIGN AND METHODS We recruited individuals with T1D who were using continuous glucose monitoring and continuous subcutaneous insulin infusion devices simultaneously to a prospective cohort and profiled them for 2 weeks. Participants were asked to report real-time dietary intake using a designated mobile app. We measured their PPGRs and devised machine learning algorithms for PPGR prediction, which integrate glucose measurements, insulin dosages, dietary habits, blood parameters, anthropometrics, exercise, and gut microbiota. Data of the PPGR of 900 healthy individuals to 41,371 meals were also integrated into the model. The performance of the models was evaluated with 10-fold cross validation. RESULTS A total of 121 individuals with T1D, 75 adults and 46 children, were included in the study. PPGR to 6,377 meals was measured. Our PPGR prediction model substantially outperforms a baseline model with emulation of standard of care (correlation of R = 0.59 compared with R = 0.40 for predicted and observed PPGR respectively; P < 10−10). The model was robust across different subpopulations. Feature attribution analysis revealed that glucose levels at meal initiation, glucose trend 30 min prior to meal, meal carbohydrate content, and meal’s carbohydrate-to-fat ratio were the most influential features for the model. CONCLUSIONS Our model enables a more accurate prediction of PPGR and therefore may allow a better adjustment of the required insulin dosage for meals. It can be further implemented in closed loop systems and may lead to rationally designed nutritional interventions personally tailored for individuals with T1D on the basis of meals with expected low glycemic response.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d194182a9697771515289a6e0ad24904Test
https://doi.org/10.2337/dc21-1048Test

10

The Management of Type 1 Diabetes in Adults. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

المؤلفون: Amy Hess-Fischl, M. Sue Kirkman, Irl B. Hirsch, Barbara Ludwig, Anne L. Peters, Eric Renard, Richard I. G. Holt, Tomasz Klupa, Ruth S. Weinstock, Jeremy Pettus, J. Hans DeVries, Jay S. Skyler, Frank J. Snoek, Kirsten Nørgaard

المساهمون: University of Southampton, University Hospital Southampton NHS Foundation Trust, University of Amsterdam [Amsterdam] (UvA), Amsterdam UMC, Profil Institute for Metabolic Research GmbH, University of Chicago, Seattle University [Seattle], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), IT University of Copenhagen, Steno Diabetes Center of Copenhagen, University of California [San Diego] (UC San Diego), University of California, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), University of Miami Leonard M. Miller School of Medicine (UMMSM), Vrije Universiteit Amsterdam [Amsterdam] (VU), SUNY Upstate Medical University, State University of New York (SUNY), Keck School of Medicine [Los Angeles], University of Southern California (USC), Amsterdam UMC - Amsterdam University Medical Center, IT University of Copenhagen (ITU), University of California (UC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Guerineau, Nathalie C., Medical psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), General Internal Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, Medical Psychology, University of Zurich, Holt, Richard I G

المصدر: Diabetologia
Diabetologia, Springer Verlag, 2021, ⟨10.1007/s00125-021-05568-3⟩
Holt, R I G, DeVries, J H, Hess-Fischl, A, Hirsch, I B, Kirkman, M S, Klupa, T, Ludwig, B, Nørgaard, K, Pettus, J, Renard, E, Skyler, J S, Snoek, F J, Weinstock, R S & Peters, A L 2021, ' The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) ', Diabetologia, vol. 64, no. 12, pp. 2609-2652 . https://doi.org/10.1007/s00125-021-05568-3Test
Diabetes Care
Diabetes Care, 2021, pp.dci210043. ⟨10.2337/dci21-0043⟩
Holt, R I G, Devries, J H, Hess-Fischl, A, Hirsch, I B, Kirkman, M S, Klupa, T, Ludwig, B, Nørgaard, K, Pettus, J, Renard, E, Skyler, J S, Snoek, F J, Weinstock, R S & Peters, A L 2021, ' The management of type 1 diabetes in adults. A consensus report by the American diabetes association (ADA) and the European association for the study of diabetes (EASD) ', Diabetes Care, vol. 44, no. 11, pp. 2589-2625 . https://doi.org/10.2337/dci21-0043Test
Diabetes Care, 44(11), 2589-2625. American Diabetes Association Inc.
Diabetes care, 44(11), 2589-2625. American Diabetes Association Inc.
Diabetologia, 64(12), 2609-2652. Springer Verlag
Diabetologia, 2021, ⟨10.1007/s00125-021-05568-3⟩
Diabetes Care, American Diabetes Association, 2021, pp.dci210043. ⟨10.2337/dci21-0043⟩

مصطلحات موضوعية: Blood Glucose, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 10265 Clinic for Endocrinology and Diabetology, 0302 clinical medicine, Diabetic ketoacidosis, Glucose monitoring, Diagnosis, Health care, Insulin, Medicine, Adjunctive therapy, 030212 general & internal medicine, Psychosocial care, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, 3. Good health, [SDV] Life Sciences [q-bio], 2712 Endocrinology, Diabetes and Metabolism, Type 1 diabetes, Psychosocial, Schedule of care, Adult, medicine.medical_specialty, Consensus, Consensus Report, 610 Medicine & health, 030209 endocrinology & metabolism, Hypoglycemia, 03 medical and health sciences, Diabetes mellitus, Internal Medicine, Hypoglycemic Agents, Humans, Association (psychology), Exercise, Nutrition, American diabetes association, Advanced and Specialized Nursing, Transplantation, business.industry, Blood Glucose Self-Monitoring, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, 2724 Internal Medicine, Family medicine, Hypoglycaemia, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and technologies and addressed the following topics: diagnosis, aims of management, schedule of care, diabetes self-management education and support, glucose monitoring, insulin therapy, hypoglycaemia, behavioural considerations, psychosocial care, diabetic ketoacidosis, pancreas and islet transplantation, adjunctive therapies, special populations, inpatient management and future perspectives. Although we discuss the schedule for follow-up examinations and testing, we have not included the evaluation and treatment of the chronic microvascular and macrovascular complications of diabetes as these are well-reviewed and discussed elsewhere. The writing group was aware of both national and international guidance on type 1 diabetes and did not seek to replicate this but rather aimed to highlight the major areas that healthcare professionals should consider when managing adults with type 1 diabetes. Though evidence-based where possible, the recommendations in the report represent the consensus opinion of the authors. [Figure not available: see fulltext.]

وصف الملف: Holt2021_Article_TheManagementOfType1DiabetesIn.pdf - application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3df907ad19780569fb44812fd42c82Test
https://doi.org/10.2337/dci21-0043Test

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