دورية أكاديمية
Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma
| العنوان: | Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma |
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| المؤلفون: | Sarton, Benjamine, Tauber, Clovis, Fridman, Estéban, Péran, Patrice, Riu, Beatrice, Vinour, Hélène, David, Adrian, Geeraerts, Thomas, Bounes, Fanny, Minville, Vincent, Delmas, Clément, Salabert, Anne-Sophie, Albucher, Jean François, Bataille, Benoit, Olivot, Jean Marc, Cariou, Alain, Naccache, Lionel, Payoux, Pierre, Schiff, Nicholas, Silva, Stein |
| المساهمون: | Association des Traumatisés du Crâne et de la Face, Fondation de l’Avenir, University Hospital of Toulouse |
| المصدر: | Brain ; volume 147, issue 4, page 1321-1330 ; ISSN 0006-8950 1460-2156 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Neurology (clinical) |
| الوصف: | The pathophysiological underpinnings of critically disrupted brain connectomes resulting in coma are poorly understood. Inflammation is potentially an important but still undervalued factor. Here, we present a first-in-human prospective study using the 18-kDa translocator protein (TSPO) radioligand 18F-DPA714 for PET imaging to allow in vivo neuroimmune activation quantification in patients with coma (n = 17) following either anoxia or traumatic brain injuries in comparison with age- and sex-matched controls. Our findings yielded novel evidence of an early inflammatory component predominantly located within key cortical and subcortical brain structures that are putatively implicated in consciousness emergence and maintenance after severe brain injury (i.e. mesocircuit and frontoparietal networks). We observed that traumatic and anoxic patients with coma have distinct neuroimmune activation profiles, both in terms of intensity and spatial distribution. Finally, we demonstrated that both the total amount and specific distribution of PET-measurable neuroinflammation within the brain mesocircuit were associated with the patient’s recovery potential. We suggest that our results can be developed for use both as a new neuroprognostication tool and as a promising biometric to guide future clinical trials targeting glial activity very early after severe brain injury. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/brain/awae045 |
| DOI: | 10.1093/brain/awae045/56774150/awae045.pdf |
| الإتاحة: | https://doi.org/10.1093/brain/awae045Test https://academic.oup.com/brain/article-pdf/147/4/1321/57162992/awae045.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.FE06FE1A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awae045 |
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